Search Results - "Toner, Mehmet"

Inertial focusing in microfluidics by Martel, Joseph M, Toner, Mehmet

“…When Segré and Silberberg in 1961 witnessed particles in a laminar pipe flow congregating at an annulus in the pipe, scientists were perplexed and spent…”
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High throughput intracellular delivery by viscoelastic mechanoporation by Sevenler, Derin, Toner, Mehmet

“…Brief pulses of electric field (electroporation) and/or tensile stress (mechanoporation) have been used to reversibly permeabilize the plasma membrane of…”
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Particle Focusing in Curved Microfluidic Channels by Martel, Joseph M., Toner, Mehmet

“…The decoupled effects of Reynolds and Dean numbers are examined in inertial focusing flows. In doing so, a complex set of inertial focusing behavioral regimes…”
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Circulating tumor cells: approaches to isolation and characterization by Yu, Min, Stott, Shannon, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A

“…Circulating tumor cells (CTCs) shed from primary and metastatic cancers are admixed with blood components and are thus rare, making their isolation and…”
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Exploring Dynamics and Structure of Biomolecules, Cryoprotectants, and Water Using Molecular Dynamics Simulations: Implications for Biostabilization and Biopreservation by Weng, Lindong, Stott, Shannon L, Toner, Mehmet

“…Successful stabilization and preservation of biological materials often utilize low temperatures and dehydration to arrest molecular motion. Cryoprotectants…”
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Rapid prototyping for high-pressure microfluidics by Rein, Carlie, Toner, Mehmet, Sevenler, Derin

“…Soft lithography has permitted rapid prototyping of precise microfluidic features by patterning a deformable elastomer such as polydimethylsiloxane (PDMS) with…”
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Continuous inertial focusing, ordering, and separation of particles in microchannels by Di Carlo, Dino, Irimia, Daniel, Tompkins, Ronald G, Toner, Mehmet

“…Under laminar flow conditions, when no external forces are applied, particles are generally thought to follow fluid streamlines. Contrary to this perspective,…”
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Molecular Dynamics at the Interface between Ice and Poly(vinyl alcohol) and Ice Recrystallization Inhibition by Weng, Lindong, Stott, Shannon L, Toner, Mehmet

“…Ice formation is a ubiquitous process that poses serious challenges for many areas. Nature has evolved a variety of different mechanisms to regulate ice…”
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Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering by Kelley, Shana O., Mirkin, Chad A., Walt, David R., Ismagilov, Rustem F., Toner, Mehmet, Sargent, Edward H.

“…This article reviews the different strategies and devices that combine nanoscale and microscale materials to bring about faster, more sensitive and reliable…”
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Cryo-Injury and Biopreservation by FOWLER, ALEX, TONER, MEHMET

“…: Mammalian cells appear to be naturally tolerant to cold temperatures, but the formation of ice when cells are cooled leads to a variety of damaging effects…”
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Clusters of circulating tumor cells traverse capillary-sized vessels by Au, Sam H., Storey, Brian D., Moore, John C., Tang, Qin, Chen, Yeng-Long, Javaid, Sarah, Sarioglu, A. Fatih, Sullivan, Ryan, Madden, Marissa W., O’Keefe, Ryan, Haber, Daniel A., Maheswaran, Shyamala, Langenau, David M., Stott, Shannon L., Toner, Mehmet

“…Multicellular aggregates of circulating tumor cells (CTC clusters) are potent initiators of distant organ metastasis. However, it is currently assumed that CTC…”
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Spontaneous migration of cancer cells under conditions of mechanical confinement by Irimia, Daniel, Toner, Mehmet

“…When cancer cells spread away from the primary tumor, they often follow the trajectories of lymphatic vessels, nerves, white matter tracts, or other…”
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Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis by Aceto, Nicola, Bardia, Aditya, Miyamoto, David T., Donaldson, Maria C., Wittner, Ben S., Spencer, Joel A., Yu, Min, Pely, Adam, Engstrom, Amanda, Zhu, Huili, Brannigan, Brian W., Kapur, Ravi, Stott, Shannon L., Shioda, Toshi, Ramaswamy, Sridhar, Ting, David T., Lin, Charles P., Toner, Mehmet, Haber, Daniel A., Maheswaran, Shyamala

“…Circulating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Using…”
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Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis by Ebright, Richard Y, Lee, Sooncheol, Wittner, Ben S, Niederhoffer, Kira L, Nicholson, Benjamin T, Bardia, Aditya, Truesdell, Samuel, Wiley, Devon F, Wesley, Benjamin, Li, Selena, Mai, Andy, Aceto, Nicola, Vincent-Jordan, Nicole, Szabolcs, Annamaria, Chirn, Brian, Kreuzer, Johannes, Comaills, Valentine, Kalinich, Mark, Haas, Wilhelm, Ting, David T, Toner, Mehmet, Vasudevan, Shobha, Haber, Daniel A, Maheswaran, Shyamala, Micalizzi, Douglas S

“…Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a small subset of these cells generates metastases. We conducted an…”
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Supercooling extends preservation time of human livers by de Vries, Reinier J., Tessier, Shannon N., Banik, Peony D., Nagpal, Sonal, Cronin, Stephanie E. J., Ozer, Sinan, Hafiz, Ehab O. A., van Gulik, Thomas M., Yarmush, Martin L., Markmann, James F., Toner, Mehmet, Yeh, Heidi, Uygun, Korkut

“…The inability to preserve vascular organs beyond several hours contributes to the scarcity of organs for transplantation 1 , 2 . Standard hypothermic…”
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RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance by Miyamoto, David T., Zheng, Yu, Wittner, Ben S., Lee, Richard J., Zhu, Huili, Broderick, Katherine T., Desai, Rushil, Fox, Douglas B., Brannigan, Brian W., Trautwein, Julie, Arora, Kshitij S., Desai, Niyati, Dahl, Douglas M., Sequist, Lecia V., Smith, Matthew R., Kapur, Ravi, Wu, Chin-Lee, Shioda, Toshi, Ramaswamy, Sridhar, Ting, David T., Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.

“…Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of androgen receptor (AR) inhibitors in recurrent disease is variable…”
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Microfluidic, marker-free isolation of circulating tumor cells from blood samples by Karabacak, Nezihi Murat, Spuhler, Philipp S, Fachin, Fabio, Lim, Eugene J, Pai, Vincent, Ozkumur, Emre, Martel, Joseph M, Kojic, Nikola, Smith, Kyle, Chen, Pin-i, Yang, Jennifer, Hwang, Henry, Morgan, Bailey, Trautwein, Julie, Barber, Thomas A, Stott, Shannon L, Maheswaran, Shyamala, Kapur, Ravi, Haber, Daniel A, Toner, Mehmet

“…The ability to isolate and analyze rare circulating tumor cells (CTCs) has the potential to further our understanding of cancer metastasis and enhance the care…”
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Multifunctional Encoded Particles for High-Throughput Biomolecule Analysis by Pregibon, Daniel C, Toner, Mehmet, Doyle, Patrick S

“…High-throughput screening for genetic analysis, combinatorial chemistry, and clinical diagnostics benefits from multiplexing, which allows for the simultaneous…”
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Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip by Park, Myoung-Hwan, Reátegui, Eduardo, Li, Wei, Tessier, Shannon N, Wong, Keith H. K, Jensen, Anne E, Thapar, Vishal, Ting, David, Toner, Mehmet, Stott, Shannon L, Hammond, Paula T

“…The detection of rare circulating tumor cells (CTCs) in the blood of cancer patients has the potential to be a powerful and noninvasive method for examining…”
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Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility by Yu, Min, Bardia, Aditya, Aceto, Nicola, Bersani, Francesca, Madden, Marissa W., Donaldson, Maria C., Desai, Rushil, Zhu, Huili, Comaills, Valentine, Zheng, Zongli, Wittner, Ben S., Stojanov, Petar, Brachtel, Elena, Sgroi, Dennis, Kapur, Ravi, Shioda, Toshihiro, Ting, David T., Ramaswamy, Sridhar, Getz, Gad, Iafrate, A. John, Benes, Cyril, Toner, Mehmet, Maheswaran, Shyamala, Haber, Daniel A.

“…Circulating tumor cells (CTCs) are present at low concentrations in the peripheral blood of patients with solid tumors. It has been proposed that the…”
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