Search Results - "Tonelli, Leonardo H."

Long-term persistence of infectious Zika virus: Inflammation and behavioral sequela in mice by Ireland, Derek D C, Manangeeswaran, Mohanraj, Lewkowicz, Aaron P, Engel, Kaliroi, Clark, Sarah M, Laniyan, Adelle, Sykes, Jacob, Lee, Ha-Na, McWilliams, Ian L, Kelley-Baker, Logan, Tonelli, Leonardo H, Verthelyi, Daniela

“…The neurodevelopmental defects associated with ZIKV infections early in pregnancy are well documented, however the potential defects and long-term consequences…”
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Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood by Clark, Sarah M., Notarangelo, Francesca M., Li, Xin, Chen, Shuo, Schwarcz, Robert, Tonelli, Leonardo H.

“…Maternal immune activation (MIA) with the viral mimic poly I:C provides an established rodent model for studying schizophrenia (SZ) and other human…”
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Association of complement component 4 with neuroimmune abnormalities in the subventricular zone in schizophrenia and autism spectrum disorders by Mou, Ta-Chung M., Lane, Malcolm V., Ireland, Derek D.C., Verthelyi, Daniela, Tonelli, Leonardo H., Clark, Sarah M.

“…An early inflammatory insult is the most recognized risk factor associated with neurodevelopmental psychiatric disorders, even more so than genetic variants…”
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The outdoor air pollution and brain health workshop by Block, Michelle L., Elder, Alison, Auten, Richard L., Bilbo, Staci D., Chen, Honglei, Chen, Jiu-Chiuan, Cory-Slechta, Deborah A., Costa, Daniel, Diaz-Sanchez, David, Dorman, David C., Gold, Diane R., Gray, Kimberly, Jeng, Hueiwang Anna, Kaufman, Joel D., Kleinman, Michael T., Kirshner, Annette, Lawler, Cindy, Miller, David S., Nadadur, Srikanth S., Ritz, Beate, Semmens, Erin O., Tonelli, Leonardo H., Veronesi, Bellina, Wright, Robert O., Wright, Rosalind J.

“…Accumulating evidence suggests that outdoor air pollution may have a significant impact on central nervous system (CNS) health and disease. To address this…”
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Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals by Clark, Sarah M., PhD, Pocivavsek, Ana, PhD, Nicholson, James D., PhD, Notarangelo, Francesca M., PhD, Langenberg, Patricia, PhD, McMahon, Robert P., PhD, Kleinman, Joel E., MD, PhD, Hyde, Thomas M., MD, PhD, Stiller, John, MD, Postolache, Teodor T., MD, Schwarcz, Robert, PhD, Tonelli, Leonardo H., PhD

“…Background Neuroinflammatory processes are increasingly believed to participate in the pathophysiology of a number of major psychiatric diseases, including…”
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Time and frequency dependent changes in resting state EEG functional connectivity following lipopolysaccharide challenge in rats by Albrecht, Matthew A, Vaughn, Chloe N, Erickson, Molly A, Clark, Sarah M, Tonelli, Leonardo H

“…Research has shown that inflammatory processes affect brain function and behavior through several neuroimmune pathways. However, high order brain functions…”
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Sex-dependent modulation of age-related cognitive decline by the L-type calcium channel gene Cacna1c (Cav1.2) by Zanos, Panos, Bhat, Shambhu, Terrillion, Chantelle E., Smith, Robert J., Tonelli, Leonardo H., Gould, Todd D.

“…Increased calcium influx through L‐type voltage‐gated calcium channels has been implicated in the neuronal dysfunction underlying age‐related memory declines…”
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Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents by Tonelli, Leonardo H, Katz, Morgan, Kovacsics, Colleen E, Gould, Todd D, Joppy, Belzora, Hoshino, Akina, Hoffman, Gloria, Komarow, Hirsh, Postolache, Teodor T

“…Abstract Epidemiological and clinical studies report higher incidences of anxiety and increased emotional reactivity in individuals suffering from respiratory…”
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Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain by TONELLI, Leonardo H, HOLMES, Andrew, POSTOLACHE, Teodor T

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Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge by Tonelli, Leonardo H., Postolache, Teodor T.

“…The capacity of the brain to activate an inflammatory reaction involving the production of cytokines in response to an immune challenge in the periphery has…”
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Expression and regulation in the brain of the chemokine CCL27 gene locus by Gunsolly, Chad, Nicholson, James D, Listwak, Samuel J, Ledee, Dolena, Zelenka, Peggy, Verthelyi, Daniela, Chapoval, Svetlana, Keegan, Achsah, Tonelli, Leonardo H

“…Abstract The chemokine CCL27 has chemoattractant properties for memory T cells and has been implicated in skin allergic reactions. The present study reports…”
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Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor by Georgiou, Polymnia, Zanos, Panos, Mou, Ta-Chung M., An, Xiaoxian, Gerhard, Danielle M., Dryanovski, Dilyan I., Potter, Liam E., Highland, Jaclyn N., Jenne, Carleigh E., Stewart, Brent W., Pultorak, Katherine J., Yuan, Peixiong, Powels, Chris F., Lovett, Jacqueline, Pereira, Edna F. R., Clark, Sarah M., Tonelli, Leonardo H., Moaddel, Ruin, Zarate, Carlos A., Duman, Ronald S., Thompson, Scott M., Gould, Todd D.

“…We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its…”
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Increased circulating regulatory T cells in medicated people with schizophrenia by Kelly, Deanna L., Li, Xin, Kilday, Catherine, Feldman, Stephanie, Clark, Sarah, Liu, Fang, Buchanan, Robert W., Tonelli, Leonardo H.

“…•Regulatory T cells are increased in the blood of stable medicated schizophrenia patients.•This increase corresponds to functional cells according to canonical…”
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Neonatal adoptive transfer of lymphocytes rescues social behaviour during adolescence in immune‐deficient mice by Clark, Sarah M., Vaughn, Chloe N., Soroka, Jennifer A., Li, Xin, Tonelli, Leonardo H.

“…Accumulating evidence has shown that lymphocytes modulate behaviour and cognition by direct interactions with the central nervous system. Studies have shown…”
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Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain by Tonelli, Leonardo H, Holmes, Andrew, Postolache, Teodor T

“…The association between activation of the immune system and mood disorders has been reported by several studies. However, the mechanisms by which the immune…”
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Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens by Postolache, Teodor T, Lapidus, Manana, Sander, Evan R, Langenberg, Patricia, Hamilton, Robert G, Soriano, Joseph J, McDonald, Jessica S, Furst, Nancy, Bai, Jie, Scrandis, Debra A, Cabassa, Johanna A, Stiller, John W, Balis, Theodora, Guzman, Alvaro, Togias, Alkis, Tonelli, Leonardo H

“…Although growing evidence supports an association between allergy, allergens and depression, it remains unknown if this relationship is between "states"…”
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CD8+ T cells promote cytokine responses to stress by Clark, Sarah M., Song, Chang, Li, Xin, Keegan, Achsah D., Tonelli, Leonardo H.

“…•Depletion of CD8+ T cells in wild type mice abrogates cytokine responses to repeated foot-shocks.•T cell deficient mice have an attenuated cytokine response…”
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Expansion of Brain T cells in Homeostatic Conditions in Lymphopenic Rag2-/- Mice by Song, Chang, Nicholson, James D, Clark, Sarah M, Li, Xin, Keegan, Achsah D, Tonelli, Leonardo H

“…Highlights • Temporal and phenotypic profiles of lymphocyte expansion in lymphopenic mouse brain. • CD4+ T cells are the most abundant lymphocyte subtype in…”
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Toxoplasma gondii Antibody Titers and History of Suicide Attempts in Patients With Recurrent Mood Disorders by Arling, Timothy A, Yolken, Robert H, Lapidus, Manana, Langenberg, Patricia, Dickerson, Faith B, Zimmerman, Sarah A, Balis, Theodora, Cabassa, Johanna A, Scrandis, Debra A, Tonelli, Leonardo H, Postolache, Teodor T

“…Toxoplasma gondii (T.gondii) is an obligate intracellular protozoan parasite infecting one-third of the world population, residing relatively silently in the…”
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Anthrax Lethal Factor Represses Glucocorticoid and Progesterone Receptor Activity by Webster, Jeanette I., Tonelli, Leonardo H., Moayeri, Mahtab, Simons, S. Stoney, Leppla, Stephen H., Sternberg, Esther M.

“…We report here that a bacterial toxin, anthrax lethal toxin (LeTx), at very low concentrations represses glucocorticoid receptor (GR) transactivation in a…”
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