Endogenous Carboxyhemoglobin Level Variation in COVID-19 and Bacterial Sepsis: A Novel Approach?

Endogenous Carboxyhemoglobin Level Variation in COVID-19 and Bacterial Sepsis: A Novel Approach?

The increased production of carbon monoxide (CO) in sepsis has been proven, but the blood level variations of carboxyhemoglobin (COHb) as a potential evolutionary parameter of COVID-19 and sepsis/septic shock have yet to be determined. This study aims to evaluate the serum level variation of COHb as...

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Bibliographic Details
Published in:Microorganisms (Basel) Vol. 10; no. 2; p. 305
Main Authors: Grigorescu, Bianca-Liana, Săplăcan, Irina, Bordea, Ioana Roxana, Petrisor, Marius, Coman, Oana, Puiac, Claudiu Ion, Toncean, Ariana, Fodor, Raluca Stefania
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 27-01-2022
MDPI
Subjects:
Age
Bacteria
Bilirubin
C-reactive protein
Carbon monoxide
Carboxyhemoglobin
Coronaviruses
Correlation
COVID-19
Cytokines
Enzymes
Failure
Hypoxia
Infections
Intensive care
lactate
Lactic acid
Liver
liver dysfunction
Observational studies
Oxidative stress
Parameters
Procalcitonin
Proteins
Respiratory distress syndrome
Sepsis
Septic shock
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Variation
Viral infections
COVID-19
liver dysfunction
carboxyhemoglobin
lactate
sepsis
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Summary:The increased production of carbon monoxide (CO) in sepsis has been proven, but the blood level variations of carboxyhemoglobin (COHb) as a potential evolutionary parameter of COVID-19 and sepsis/septic shock have yet to be determined. This study aims to evaluate the serum level variation of COHb as a potential evolutionary parameter in COVID-19 critically ill patients and in bacterial sepsis. A prospective and observational study was conducted on two groups of patients: the bacterial sepsis group ( = 52) and the COVID-19 group ( = 52). We followed paraclinical parameters on Day 1 (D1) and Day 5 (D5) of sepsis/ICU admission for COVID-19 patients. D1 of sepsis: statistically significant positive correlations between: COHb values and serum lactate ( = 0.024, r = 0.316), and total bilirubin ( = 0.01, r = 0.359). In D5 of sepsis: a statistically significant positive correlations between: COHb values and procalcitonin (PCT) ( = 0.038, r = 0.402), and total bilirubin ( = 0.023, r = 0.319). D1 of COVID-19 group: COHb levels were statistically significantly positively correlated with C-reactive protein CRP values ( = 0.003, r = 0.407) and with PCT values ( = 0.022, r = 0.324) and statistically significantly negatively correlated with serum lactate values ( = 0.038, r = -0.285). COHb variation could provide rapid information about the outcome of bacterial sepsis/septic shock, having the advantages of a favorable cost-effectiveness ratio, and availability as a point-of-care test.
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ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10020305