Search Results - "Ton J. Rabelink"

Stem cell-derived kidney organoids: engineering the vasculature by Koning, Marije, van den Berg, Cathelijne W., Rabelink, Ton J.

“…Kidney organoids can be generated from human pluripotent stem cells (PSCs) using protocols that resemble the embryonic development of the kidney. The renal…”
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Functional and Cognitive Impairment, Frailty, and Adverse Health Outcomes in Older Patients Reaching ESRD-A Systematic Review by Kallenberg, Marije H, Kleinveld, Hilda A, Dekker, Friedo W, van Munster, Barbara C, Rabelink, Ton J, van Buren, Marjolijn, Mooijaart, Simon P

“…Older patients reaching ESRD have a higher risk of adverse health outcomes. We aimed to determine the association of functional and cognitive impairment and…”
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Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation by Dumas, Sébastien J, Meta, Elda, Borri, Mila, Goveia, Jermaine, Rohlenova, Katerina, Conchinha, Nadine V, Falkenberg, Kim, Teuwen, Laure-Anne, de Rooij, Laura, Kalucka, Joanna, Chen, Rongyuan, Khan, Shawez, Taverna, Federico, Lu, Weisi, Parys, Magdalena, De Legher, Carla, Vinckier, Stefan, Karakach, Tobias K, Schoonjans, Luc, Lin, Lin, Bolund, Lars, Dewerchin, Mieke, Eelen, Guy, Rabelink, Ton J, Li, Xuri, Luo, Yonglun, Carmeliet, Peter

“…Renal endothelial cells from glomerular, cortical, and medullary kidney compartments are exposed to different microenvironmental conditions and support…”
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Phenotypic diversity and metabolic specialization of renal endothelial cells by Dumas, Sébastien J., Meta, Elda, Borri, Mila, Luo, Yonglun, Li, Xuri, Rabelink, Ton J., Carmeliet, Peter

“…Complex multicellular life in mammals relies on functional cooperation of different organs for the survival of the whole organism. The kidneys play a critical…”
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Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis by Wang, Gangqi, Kostidis, Sarantos, Tiemeier, Gesa L., Sol, Wendy M.P.J., de Vries, Margreet R., Giera, Martin, Carmeliet, Peter, van den Berg, Bernard M., Rabelink, Ton J.

“…OBJECTIVE:Endothelial cells exposed to laminar shear stress express a thick glycocalyx on their surface that plays an important role in reducing vascular…”
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Unveiling the role of Mfsd2a and LPC-DHA in kidney repair by Rietjens, Rosalie G.J., Rabelink, Ton J.

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Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes by Haller, Hermann, Ito, Sadayoshi, Izzo, Joseph L, Januszewicz, Andrzej, Katayama, Shigehiro, Menne, Jan, Mimran, Albert, Rabelink, Ton J, Ritz, Eberhard, Ruilope, Luis M, Rump, Lars C, Viberti, Giancarlo

“…This study investigated whether an angiotensin-receptor blocker (olmesartan) would delay microalbuminuria in patients with type 2 diabetes and…”
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Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo by van den Berg, Cathelijne W., Ritsma, Laila, Avramut, M. Cristina, Wiersma, Loes E., van den Berg, Bernard M., Leuning, Daniëlle G., Lievers, Ellen, Koning, Marije, Vanslambrouck, Jessica M., Koster, Abraham J., Howden, Sara E., Takasato, Minoru, Little, Melissa H., Rabelink, Ton J.

“…Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease modeling and the generation of tissue for renal replacement. Long-term…”
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Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity by Leenders, Floris, Groen, Nathalie, de Graaf, Natascha, Engelse, Marten A, Rabelink, Ton J, de Koning, Eelco J P, Carlotti, Françoise

“…Pancreatic β-cell failure is a critical event in the onset of both main types of diabetes mellitus but underlying mechanisms are not fully understood. β-cells…”
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The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment by Leuning, Daniëlle G., Beijer, Nick R. M., du Fossé, Nadia A., Vermeulen, Steven, Lievers, Ellen, van Kooten, Cees, Rabelink, Ton J., Boer, Jan de

“…Mesenchymal stromal cells (MSC) secrete factors that contribute to organ homeostasis and repair in a tissue specific manner. For instance, kidney perivascular…”
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PR3-ANCAs predict relapses in ANCA-associated vasculitis patients after rituximab by van Dam, Laura S, Dirikgil, Ebru, Bredewold, Edwin W, Ray, Argho, Bakker, Jaap A, van Kooten, Cees, Rabelink, Ton J, Teng, Yoe K Onno

“…Abstract Background. The primary challenge of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patient care is the early detection of…”
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Aspirin treatment hampers the use of plasma microRNA-126 as a biomarker for the progression of vascular disease by de Boer, Hetty C, van Solingen, Coen, Prins, Jurriën, Duijs, Jacques M G J, Huisman, Menno V, Rabelink, Ton J, van Zonneveld, Anton Jan

“…MicroRNA-126 (miR-126) facilitates angiogenesis and regulates endothelial cell function. Recent data suggest that miR-126 can serve as a biomarker for vascular…”
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Intrinsically Distinct Role of Neutrophil Extracellular Trap Formation in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Compared to Systemic Lupus Erythematosus by Dam, Laura S., Kraaij, Tineke, Kamerling, Sylvia W. A., Bakker, Jaap A., Scherer, Uli H., Rabelink, Ton J., Kooten, Cees, Teng, Y. K. Onno

“…Objective Different studies have demonstrated that neutrophil extracellular traps (NETs) may be involved in the pathophysiology of both antineutrophil…”
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Will New Treatment Options for Lupus Nephritis Be Affordable? by Teng, Y K Onno, Rabelink, Ton J

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Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx by Garsen, Marjolein, Lenoir, Olivia, Rops, Angelique L W M M, Dijkman, Henry B, Willemsen, Brigith, van Kuppevelt, Toin H, Rabelink, Ton J, Berden, Jo H M, Tharaux, Pierre-Louis, van der Vlag, Johan

“…Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Endothelin receptor antagonists have emerged as a novel treatment for DN, but the…”
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Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy by Boels, Margien G S, Avramut, M Cristina, Koudijs, Angela, Dane, Martijn J C, Lee, Dae Hyun, van der Vlag, Johan, Koster, Abraham J, van Zonneveld, Anton Jan, van Faassen, Ernst, Gröne, Hermann-Josef, van den Berg, Bernard M, Rabelink, Ton J

“…Atrasentan, a selective endothelin A receptor antagonist, has been shown to reduce albuminuria in type 2 diabetes. We previously showed that the structural…”
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Glomerular Function and Structural Integrity Depend on Hyaluronan Synthesis by Glomerular Endothelium by van den Berg, Bernard M, Wang, Gangqi, Boels, Margien G S, Avramut, M Cristina, Jansen, Erik, Sol, Wendy M P J, Lebrin, Franck, van Zonneveld, Anton Jan, de Koning, Eelco J P, Vink, Hans, Gröne, Hermann-Josef, Carmeliet, Peter, van der Vlag, Johan, Rabelink, Ton J

“…A glycocalyx envelope consisting of proteoglycans and adhering proteins covers endothelial cells, both the luminal and abluminal surface. We previously…”
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Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy by Boels, Margien G.S., Koudijs, Angela, Avramut, M. Cristina, Sol, Wendy M.P.J., Wang, Gangqi, van Oeveren-Rietdijk, Annemarie M., van Zonneveld, Anton Jan, de Boer, Hetty C., van der Vlag, Johan, van Kooten, Cees, Eulberg, Dirk, van den Berg, Bernard M., IJpelaar, Daphne H.T., Rabelink, Ton J.

“…Inhibition of monocyte chemotactic protein-1 (MCP-1) with the Spiegelmer emapticap pegol (NOX-E36) shows long-lasting albuminuria-reducing effects in diabetic…”
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Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion by Lee, Dae Hyun, Dane, Martijn J C, van den Berg, Bernard M, Boels, Margien G S, van Teeffelen, Jurgen W, de Mutsert, Renée, den Heijer, Martin, Rosendaal, Frits R, van der Vlag, Johan, van Zonneveld, Anton Jan, Vink, Hans, Rabelink, Ton J

“…Changes in endothelial glycocalyx are one of the earliest changes in development of cardiovascular disease. The endothelial glycocalyx is both an important…”
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A microscopic view on the renal endothelial glycocalyx by Dane, Martijn J C, van den Berg, Bernard M, Lee, Dae Hyun, Boels, Margien G S, Tiemeier, Gesa L, Avramut, M Cristina, van Zonneveld, Anton Jan, van der Vlag, Johan, Vink, Hans, Rabelink, Ton J

“…Endothelial cells perform key homeostatic functions such as regulating blood flow, permeability, and aiding immune surveillance for pathogens. While…”
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