Search Results - "Tomusange, Stephen"
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HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy
Published in Nature communications (02-07-2024)“…The primary obstacle to curing HIV-1 is a reservoir of CD4+ cells that contain stably integrated provirus. Previous studies characterizing the proviral…”
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Effective and targeted latency reversal in CD4 + T cells from individuals on long term combined antiretroviral therapy initiated during chronic HIV-1 infection
Published in Emerging microbes & infections (01-12-2024)“…To date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most "latency reversal" agents (LRAs) lacking specificity for the…”
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Inferring HIV-1 transmission networks and sources of epidemic spread in Africa with deep-sequence phylogenetic analysis
Published in Nature communications (29-03-2019)“…To prevent new infections with human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa, UNAIDS recommends targeting interventions to populations that…”
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Effectiveness of Voluntary Medical Male Circumcision for Human Immunodeficiency Virus Prevention in Rakai, Uganda
Published in Clinical infectious diseases (05-10-2021)“…The efficacy of voluntary male medical circumcision (VMMC) for human immunodeficiency virus (HIV) prevention in men was demonstrated in 3 randomized trials…”
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Quantifying HIV transmission flow between high-prevalence hotspots and surrounding communities: a population-based study in Rakai, Uganda
Published in The lancet HIV (01-03-2020)“…International and global organisations advocate targeting interventions to areas of high HIV prevalence (ie, hotspots). To better understand the potential…”
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The HIV and sexually transmitted infection syndemic following mass scale-up of combination HIV interventions in two communities in southern Uganda: a population-based cross-sectional study
Published in The Lancet global health (01-12-2022)“…Combination HIV prevention and treatment interventions (CHIs) have led to substantial declines in HIV incidence in sub-Saharan Africa; however,…”
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Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimen
Published in EBioMedicine (01-04-2024)“…The principal barrier to an HIV cure is the presence of the latent viral reservoir (LVR), which has been understudied in African populations. From 2018 to…”
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Temporary increase in circulating replication-competent latent HIV-infected resting CD4+ T cells after switch to an integrase inhibitor based antiretroviral regimenResearch in context
Published in EBioMedicine (01-04-2024)“…Background: The principal barrier to an HIV cure is the presence of the latent viral reservoir (LVR), which has been understudied in African populations. From…”
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Dating reservoir formation in virologically suppressed people living with HIV-1 in Rakai, Uganda
Published in Virus evolution (01-12-2023)“…Abstract The timing of the establishment of the HIV latent viral reservoir (LVR) is of particular interest, as there is evidence that proviruses are…”
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