T2 measurement of the knee articular cartilage in osteoarthritis at 3T

Purpose: To measure reproducibility, longitudinal and cross‐sectional differences in T2* maps at 3 Tesla (T) in the articular cartilage of the knee in subjects with osteoarthritis (OA) and healthy matched controls. Materials and Methods: MRI data and standing radiographs were acquired from 33 subjec...

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Bibliographic Details
Published in:	Journal of magnetic resonance imaging Vol. 35; no. 6; pp. 1422 - 1429
Main Authors:	Newbould, Rexford D., Miller, Sam R., Toms, Laurence D., Swann, Peter, Tielbeek, Jeroen A.W., Gold, Garry E., Strachan, Robin K., Taylor, Peter C., Matthews, Paul M., Brown, Andrew P.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-06-2012
Subjects:	cartilage Cartilage, Articular - pathology Female Humans Knee Joint - pathology Magnetic Resonance Imaging - methods Male Middle Aged MRI osteoarthritis Osteoarthritis, Knee - pathology Reproducibility of Results Sensitivity and Specificity
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Summary:	Purpose: To measure reproducibility, longitudinal and cross‐sectional differences in T2* maps at 3 Tesla (T) in the articular cartilage of the knee in subjects with osteoarthritis (OA) and healthy matched controls. Materials and Methods: MRI data and standing radiographs were acquired from 33 subjects with OA and 21 healthy controls matched for age and gender. Reproducibility was determined by two sessions in the same day, while longitudinal and cross‐sectional group differences used visits at baseline, 3 and 6 months. Each visit contained symptomological assessments and an MRI session consisting of high resolution three‐dimensional double‐echo‐steady‐state (DESS) and co‐registered T2* maps of the most diseased knee. A blinded reader delineated the articular cartilage on the DESS images and median T2* values were reported. Results: T2* values showed an intra‐visit reproducibility of 2.0% over the whole cartilage. No longitudinal effects were measured in either group over 6 months. T2* maps revealed a 5.8% longer T2* in the medial tibial cartilage and 7.6% and 6.5% shorter T2* in the patellar and lateral tibial cartilage, respectively, in OA subjects versus controls (P < 0.02). Conclusion: T2* mapping is a repeatable process that showed differences between the OA subject and control groups. J. Magn. Reson. Imaging 2012;35:1422–1429. © 2012 Wiley Periodicals Inc.
Bibliography:	ark:/67375/WNG-Q01ML43G-Q istex:01BCC2B8CB8C628BCF021310BF596DC82B9EF6AF ArticleID:JMRI23598 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1053-1807 1522-2586
DOI:	10.1002/jmri.23598