Search Results - "Tomoyuki Kawai"

hERG trafficking inhibition in drug-induced lethal cardiac arrhythmia by Nogawa, Hisashi, Kawai, Tomoyuki

“…Acquired long QT syndrome induced by non-cardiovascular drugs can cause lethal cardiac arrhythmia called torsades de points and is a significant problem in…”
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Fiber type-specific afferent nerve activity induced by transient contractions of rat bladder smooth muscle in pathological states by Kuga, Nahoko, Tanioka, Asao, Hagihara, Koichiro, Kawai, Tomoyuki

“…Bladder smooth muscle shows spontaneous phasic contractions, which undergo a variety of abnormal changes depending on pathological conditions. How abnormal…”
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Modulation of afferent nerve activity by prostaglandin E2 upon urinary bladder distension in rats by Kuga, Nahoko, Tanioka, Asao, Hagihara, Koichiro, Kawai, Tomoyuki

“…New Findings What is the central question of this study? It has been widely assumed that C fibres innervating the bladder are mainly excited in overactive…”
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Histopathological and electron microscopic study in dogs with patellar luxation and skin hyperextensibility by UEDA, Kazunori, KAWAI, Tomoyuki, SENOO, Haruki, SHIMIZU, Atsushi, ISHIKO, Akira, NAGATA, Masahiko

“…Patellar luxation is abnormal displacement of the patella from the femoral trochlear groove. It is seen primarily in small breed dogs and causes pain and…”
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Crystal structure of UDP-galactose 4-epimerase from the hyperthermophilic archaeon Pyrobaculum calidifontis by Sakuraba, Haruhiko, Kawai, Tomoyuki, Yoneda, Kazunari, Ohshima, Toshihisa

“…► The crystal structure of the hyperthermophilic UDP-galactose 4-epimerase (GalE) was determined. ► The hydrophobic inter-subunit interaction is responsible…”
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Feedback stabilization involving redox states of c-type cytochromes in living bacteria by Liu, Huan, Matsuda, Shoichi, Kawai, Tomoyuki, Hashimoto, Kazuhito, Nakanishi, Shuji

“…The formal potential of c-type cytochromes expressed in the bacterial outer membrane was dependent on their redox state functioning in mediating extracellular…”
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Effects of probucol, a typical hERG expression inhibitor, on in vivo QT interval prolongation in conscious dogs by Nogawa, Hisashi, Kawai, Tomoyuki, Yajima, Miho, Miura, Masahiro, Ogawa, Tetsurou, Murakami, Kouji

“…The cholesterol-lowering drug, probucol, is known to induce QT interval prolongation and torsades de pointes in patients. Recent in vitro studies have…”
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A simple method for minimizing non-linear image contrast in spherical aberration-corrected HRTEM by Yamasaki, Jun, Kawai, Tomoyuki, Tanaka, Nobuo

“…A simple and practical method for minimizing non-linear image contrast in spherical aberration-corrected (Cs-corrected) high-resolution transmission electron…”
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Pharmacological characterisation of electrocardiogram J-T peak interval in conscious Guinea pigs by Nogawa, Hisashi, Muraki, Yukiko, Kawai, Tomoyuki, Kuninishi, Yoshiharu

“…Drug-induced human ether-à-go-go-related gene (hERG) channel block and QT interval prolongation increase torsade de pointes (TdP) risk. However, some drugs…”
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Pharmacological characterisation of electrocardiogram J-Tpeak interval in conscious Guinea pigs by Nogawa, Hisashi, Muraki, Yukiko, Kawai, Tomoyuki, Kuninishi, Yoshiharu

“…Drug-induced human ether-à-go-go-related gene (hERG) channel block and QT interval prolongation increase torsade de pointes (TdP) risk. However, some drugs…”
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Bone-Demineralized bone-Bone Grafts for Ligament Reconstruction by Takeki YAMADA, Yoshihisa KOYAMA, Tomoyuki KAWAI, Takeshi MUNETA, Kazuo TAKAKUDA

“…Ligament reconstruction with the use of novel demineralized bone grafts was investigated in a rabbit model. By demineralizing only the central portions of the…”
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Modulation of afferent nerve activity by prostaglandin E 2 upon urinary bladder distension in rats by Kuga, Nahoko, Tanioka, Asao, Hagihara, Koichiro, Kawai, Tomoyuki

“…New Findings What is the central question of this study? It has been widely assumed that C fibres innervating the bladder are mainly excited in overactive…”
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In vitro and in silico study on consequences of combined exposure to the food-borne alkenylbenzenes estragole and safrole by Yang, Shuo, Kawai, Tomoyuki, Wesseling, Sebastiaan, Rietjens, Ivonne M.C.M.

“…Potential consequences of combined exposure to the selected food-borne alkenylbenzenes safrole and estragole or their proximate carcinogenic 1′-hydroxy…”
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Modulation of afferent nerve activity by prostaglandin E sub(2) upon urinary bladder distension in rats by Kuga, Nahoko, Tanioka, Asao, Hagihara, Koichiro, Kawai, Tomoyuki

“…New Findings * What is the central question of this study? It has been widely assumed that C fibres innervating the bladder are mainly excited in overactive…”
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Biological fixation of fibrous materials to bone using chitin/chitosan as a bone formation accelerator by Kawai, Tomoyuki, Yamada, Takeki, Yasukawa, Akio, Koyama, Yoshihisa, Muneta, Takeshi, Takakuda, Kazuo

“…Biological fixation or anchorage of fibrous materials to bone by bone ingrowth into the spaces between fibers is a major concern in developing novel medical…”
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Anterior Cruciate Ligament Reconstruction Using Chitin-coated Fabrics in a Rabbit Model by Kawai, Tomoyuki, Yamada, Takeki, Yasukawa, Akio, Koyama, Yoshihisa, Muneta, Takeshi, Takakuda, Kazuo

“…Experimental anterior cruciate ligament (ACL) reconstruction was carried out in a rabbit model, in which a chitin‐coated polyester graft was used as the…”
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Sound processing system by Maeda, Kengo, Kawai, Tomoyuki

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Nonpeptide Angiotensin II Receptor Antagonists. I. Synthesis and Biological Activity of Pyridine Derivatives by UEYAMA, Naoto, YANAGISAWA, Takashi, KAWAI, Tomoyuki, SONEGAWA, Motoharu, BABA, Hiromi, MOCHIZUKI, Seiichiro, KOSAKAI, Kazuhiro, TOMIYAMA, Tsuyoshi

“…Substituted pyridines were synthesized as potential angiotensin II (AII) receptor antagonists. Substitution at the position 2 in the pyridine resulted in…”
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Structure of a UDP-glucose dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum by Sakuraba, Haruhiko, Kawai, Tomoyuki, Yoneda, Kazunari, Ohshima, Toshihisa

“…The crystal structure of an extremely thermostable UDP‐glucose dehydrogenase (UDP‐GDH) from the hyperthermophilic archaeon Pyrobaculum islandicum was…”
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A Novel Synthesis of L-Pyroglutamic Acid Derivatives from L-Proline : Utility of N-Protecting Groups for Ruthenium Tetroxide Oxidation of Cyclic α-Amino Acids by YOSHIFUJI, SHIGEYUKI, TANAKA, KEN-ICHI, KAWAI, TOMOYUKI, NITTA, YOSHIHIRO

“…The utility of four urethane type N-protecting groups, benzyloxycarbonyl (Z), p-nitro-benzyloxycarbonyl [Z(NO2)], trichloroethoxycarboyl (Troc) and…”
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