Search Results - "Tomosugi, Mitsuhiro"

Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells by Tanaka, Ryoichi, Tomosugi, Mitsuhiro, Horinaka, Mano, Sowa, Yoshihiro, Sakai, Toshiyuki

“…Although many chemotherapeutic strategies against cancer have been developed, pancreatic cancer is one of the most aggressive and intractable types of…”
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Cross-talk among MEN1, p53 and Notch regulates the proliferation of pancreatic neuroendocrine tumor cells by modulating INSM1 expression and subcellular localization by Capodanno, Ylenia, Chen, Yu, Schrader, Joerg, Tomosugi, Mitsuhiro, Sumi, Shoiciro, Yokoyama, Akihiko, Hiraoka, Nobuyoshi, Ohki, Rieko

“…Genomic analysis of Pancreatic Neuroendocrine Tumors (PanNETs) has revealed that these tumors often lack mutations in typical cancer-related genes such as the…”
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LIF–IGF Axis Contributes to the Proliferation of Neural Progenitor Cells in Developing Rat Cerebrum by Takata, Sho, Sakata-Haga, Hiromi, Shimada, Hiroki, Tsukada, Tsuyoshi, Sakai, Daisuke, Shoji, Hiroki, Tomosugi, Mitsuhiro, Nakamura, Yuka, Ishigaki, Yasuhito, Iizuka, Hideaki, Hayashi, Yasuhiko, Hatta, Toshihisa

“…In rodent models, leukemia inhibitory factor (LIF) is involved in cerebral development via the placenta, and maternal immune activation is linked to…”
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Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model by Sakai, Daisuke, Sugawara, Takeru, Kurokawa, Tomonori, Murakami, Yuki, Tomosugi, Mitsuhiro, Masuta, Hiroko, Sakata-Haga, Hiromi, Hatta, Toshihisa, Shoji, Hiroki

“…Hypoxia-inducible factor 1 α (Hif1α) plays a crucial role in brain development. To study the function of Hif1α in early brain development, we generated…”
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Glycolytic activity is required for the onset of neural plate folding during neural tube closure in mouse embryos by Sakai, Daisuke, Murakami, Yuki, Shigeta, Daichi, Tomosugi, Mitsuhiro, Sakata-Haga, Hiromi, Hatta, Toshihisa, Shoji, Hiroki

“…Physiological hypoxia is critical for placental mammalian development. However, the underlying mechanisms by which hypoxia regulates embryonic development…”
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Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast by Wang, He, Sakata-Haga, Hiromi, Masuta, Hiroko, Tomosugi, Mitsuhiro, Tsukada, Tsuyoshi, Shimada, Hiroki, Sakai, Daisuke, Shoji, Hiroki, Hatta, Toshihisa

“…We previously showed that maternal leukemia inhibitory factor (LIF) induces placental production of adrenocorticotropic hormone (ACTH), which stimulates fetal…”
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Retinoblastoma gene‐independent G1 phase arrest by flavone, phosphatidylinositol 3‐kinase inhibitor, and histone deacetylase inhibitor by Tomosugi, Mitsuhiro, Sowa, Yoshihiro, Yasuda, Shusuke, Tanaka, Ryoichi, te Riele, Hein, Ikawa, Haruna, Koyama, Makoto, Sakai, Toshiyuki

“…In most human malignant tumors, retinoblastoma tumor‐suppressor gene (RB) product is inactivated by phosphorylation. Therefore, cancer preventive agents or…”
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MC5R Contributes to Sensitivity to UVB Waves and Barrier Function in Mouse Epidermis by Shintani, Akari, Sakata-Haga, Hiromi, Moriguchi, Keiichi, Tomosugi, Mitsuhiro, Sakai, Daisuke, Tsukada, Tsuyoshi, Taniguchi, Makoto, Asano, Masahide, Shimada, Hiroki, Otani, Hiroki, Shoji, Hiroki, Hatta, Junko, Mochizuki, Takashi, Hatta, Toshihisa

“…MC5R is known for its role in the exocrine function of sebaceous glands, but other functions in the epidermis remain unclear. This study focused on the…”
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Aclarubicin enhances tumor necrosis factor‐related apoptosis‐inducing ligand‐induced apoptosis through death receptor 5 upregulation by Horinaka, Mano, Yoshida, Tatsushi, Nakata, Susumu, Shiraishi, Takumi, Tomosugi, Mitsuhiro, Yoshikawa, Sae, Wakada, Miki, Sakai, Toshiyuki

“…Anthracycline drugs are potent anti‐tumor agents. Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) is a death ligand with promising anti‐cancer…”
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Synthesis of phosphatidylcholine: An improved method without using the cadmium chloride complex of sn-glycero-3-phosphocholine by Ichihara, Ken’ichi, Iwasaki, Hitomi, Ueda, Kaori, Takizawa, Ryoko, Naito, Hideko, Tomosugi, Mitsuhiro

“…An improved safe method that does not contaminate the environment with cadmium chloride, a toxic heavy metal salt, was developed for the synthesis of…”
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Histone Deacetylase Inhibitors and 15-Deoxy-Δ12,14-Prostaglandin J2 Synergistically Induce Apoptosis by Koyama, Makoto, Izutani, Yasuyuki, Goda, Ahmed E., Matsui, Taka-aki, Horinaka, Mano, Tomosugi, Mitsuhiro, Fujiwara, Jun, Nakamura, Yoshitaka, Wakada, Miki, Yogosawa, Shingo, Sowa, Yoshihiro, Sakai, Toshiyuki

“…Purpose: The clinically relevant histone deacetylase inhibitors (HDI) valproic acid (VPA) and suberoylanilide hydroxamic acid exert variable antitumor…”
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Mechanisms of ACTH induction in mouse trophoblast stem cells by LIF by Shoji, Hiroki, Wang, He, Sakata-Haga, Hiromi, Masuta, Hiroko, Tomosugi, Mitsuhiro, Tsukada, Tsuyoshi, Shimada, Hiroki, Sakai, Daisuke, Hatta, Toshihisa

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MEK Inhibitor Suppresses Expression of the miR-17-92 Cluster with G1-Phase Arrest in HT-29 Human Colon Cancer Cells and MIA PaCa-2 Pancreatic Cancer Cells by Tanaka, Ryoichi, Tomosugi, Mitsuhiro, Sakai, Toshiyuki, Sowa, Yoshihiro

“…MicroRNAs (miRNAs) are small non-coding RNAs, and the deregulated expression of miRNAs is associated with tumor development. Among these, the miR-17-92…”
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Hif1[alpha]-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model by Sakai, Daisuke, Sugawara, Takeru, Kurokawa, Tomonori, Murakami, Yuki, Tomosugi, Mitsuhiro, Masuta, Hiroko, Sakata-Haga, Hiromi, Hatta, Toshihisa, Shoji, Hiroki

“…Hypoxia-inducible factor 1 [alpha] (Hif1[alpha]) plays a crucial role in brain development. To study the function of Hif1[alpha] in early brain development, we…”
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Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma by Hagiwara, Nobuhisa, Watanabe, Motoki, Iizuka-Ohashi, Mahiro, Yokota, Isao, Toriyama, Seijiro, Sukeno, Mamiko, Tomosugi, Mitsuhiro, Sowa, Yoshihiro, Hongo, Fumiya, Mikami, Kazuya, Soh, Jintetsu, Fujito, Akira, Miyashita, Hiroaki, Morioka, Yukako, Miki, Tsuneharu, Ukimura, Osamu, Sakai, Toshiyuki

“…Renal cell carcinoma (RCC) is the most common malignancy of kidney and remains largely intractable once it recurs after resection. mTOR inhibitors have been…”
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Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells by Horinaka, Mano, Yoshida, Tatsushi, Tomosugi, Mitsuhiro, Yasuda, Shusuke, Sowa, Yoshihiro, Sakai, Toshiyuki

“…A combined therapy of sulindac sulfide and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising strategy for the treatment of cancer…”
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Ibuprofen enhances TRAIL-induced apoptosis through DR5 upregulation by TODO, MOMOKO, HORINAKA, MANO, TOMOSUGI, MITSUHIRO, TANAKA, RYOICHI, IKAWA, HARUNA, SOWA, YOSHIHIRO, ISHIKAWA, HIDEKI, FUJIWARA, HITOSHI, OTSUJI, EIGO, SAKAI, TOSHIYUKI

“…Numerous human chemoprevention studies have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) possess chemopreventive effects against a variety…”
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Retinoblastoma gene‐independent G 1 phase arrest by flavone, phosphatidylinositol 3‐kinase inhibitor, and histone deacetylase inhibitor by Tomosugi, Mitsuhiro, Sowa, Yoshihiro, Yasuda, Shusuke, Tanaka, Ryoichi, te Riele, Hein, Ikawa, Haruna, Koyama, Makoto, Sakai, Toshiyuki

“…In most human malignant tumors, retinoblastoma tumor‐suppressor gene ( RB ) product is inactivated by phosphorylation. Therefore, cancer preventive agents or…”
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Polyamines are essential for the synthesis of 2-ricinoleoyl phosphatidic acid in developing seeds of castor by Tomosugi, M, Ichihara, K, Saito, K

“…The major fatty acid component of castor (Ricinus communis L.) oil is ricinoleic acid (12-hydroxy-cis-9-octadecenoic acid), and unsaturated hydroxy acid…”
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Abstract 5415: Histone deacetylase inhibitors and 15-deoxy-Δ12,14-prostaglandin J2 synergistically induce apoptosis by Koyama, Makoto, Izutani, Yasuyuki, Goda, Ahmed E., Matsui, Taka-aki, Horinaka, Mano, Tomosugi, Mitsuhiro, Fujiwara, Jun, Nakamura, Yoshitaka, Wakada, Miki, Yogosawa, Shingo, Sowa, Yoshihiro, Sakai, Toshiyuki

“…The histone deacetylase inhibitors (HDIs) valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA, vorinostat) are used clinically for the treatment of…”
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