Search Results - "Tomono, Takumi"

Advances in Studies of P-Glycoprotein and Its Expression Regulators by Yano, Kentaro, Tomono, Takumi, Ogihara, Takuo

“…This review deals with recent advances in studies on P-glycoprotein (P-gp) and its expression regulators, focusing especially on our own research. Firstly, we…”
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Snail-Induced Epithelial-to-Mesenchymal Transition Enhances P-gp-Mediated Multidrug Resistance in HCC827 Cells by Tomono, Takumi, Yano, Kentaro, Ogihara, Takuo

“…Overexpression and activation of P-glycoprotein (P-gp), which mediates efflux transport of various anticancer drugs in cancer cells, is associated with…”
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Functional Alterations of Multidrug Resistance-Associated Proteins 2 and 5, and Breast Cancer Resistance Protein upon Snail-Induced Epithelial–Mesenchymal Transition in HCC827 Cells by Yano, Kentaro, Todokoro, Itsuki, Kamioka, Hiroki, Tomono, Takumi, Ogihara, Takuo

“…Our previous report indicated that Snail-induced epithelial–mesenchymal transition (EMT) enhanced P-glycoprotein (P-gp) function and drug resistance to P-gp…”
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Gastrointestinal Hormone Cholecystokinin Increases P-Glycoprotein Membrane Localization and Transport Activity in Caco-2 Cells by Yano, Kentaro, Shimizu, Saori, Tomono, Takumi, Ogihara, Takuo

“…It was reported that stimulation of taste receptor type 2 member 38 by a bitter substance, phenylthiocarbamide (PTC), increased P-glycoprotein (P-gp) mRNA…”
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Performance of Cell-Penetrating Peptides Anchored to Polysaccharide Platforms Applied via Various Mucosal Routes as an Absorption Enhancer by Yagi, Haruya, Tomono, Takumi, Handa, Yuma, Saito, Natsuki, Ukawa, Masami, Miyata, Kohei, Shigeno, Koichi, Sakuma, Shinji

“…We have been investigating the potential of cell-penetrating peptides anchored to polymeric platforms as a novel absorption enhancer which delivers biologics…”
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Drug resistance via radixin-mediated increase of P-glycoprotein membrane expression during SNAI1-induced epithelial-mesenchymal transition in HepG2 cells by Kamioka, Hiroki, Edaki, Kazue, Kasahara, Haruka, Tomono, Takumi, Yano, Kentaro, Ogihara, Takuo

“…Epithelial-mesenchymal transition (EMT) plays a role in cancer metastasis as well as in drug resistance through various mechanisms, including increased drug…”
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Adenovirus vector infection of non-small-cell lung cancer cells is a trigger for multi-drug resistance mediated by P-glycoprotein by Tomono, Takumi, Kajita, Masahiro, Yano, Kentaro, Ogihara, Takuo

“…P-glycoprotein (P-gp) is an ATP-binding cassette protein involved in cancer multi-drug resistance (MDR). It has been reported that infection with some bacteria…”
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The Improved Antigen Uptake and Presentation of Dendritic Cells Using Cell-Penetrating D-octaarginine-Linked PNVA-co-AA as a Novel Dendritic Cell-Based Vaccine by Fujioka, Yuri, Ueki, Hideto, A, Ruhan, Sasajima, Akari, Tomono, Takumi, Ukawa, Masami, Yagi, Haruya, Sakuma, Shinji, Kitagawa, Koichi, Shirakawa, Toshiro

“…Cancer immunotherapy using antigen-pulsed dendritic cells can induce strong cellular immune responses by priming cytotoxic T lymphocytes. In this study, we…”
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Evaluation of a D-Octaarginine-linked polymer as a transfection tool for transient and stable transgene expression in human and murine cell lines by SAKUMA, Saki, OKAMOTO, Mariko, MATSUSHITA, Nao, UKAWA, Masami, TOMONO, Takumi, KAWAMOTO, Keiko, IKEDA, Teruo, SAKUMA, Shinji

“…Poly(N-vinylacetamide-co-acrylic acid) coupled with d-octaarginine (VP-R8) promotes the cellular uptake of peptides/proteins in vitro; however, details of the…”
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Entinostat reverses P-glycoprotein activation in snail-overexpressing adenocarcinoma HCC827 cells by Tomono, Takumi, Machida, Tatsuya, Kamioka, Hiroki, Shibasaki, Yumi, Yano, Kentaro, Ogihara, Takuo

“…Epithelial-to-mesenchymal transition (EMT) in cancer cells facilitates tumor progression by promoting invasion and metastasis. Snail is a transcriptional…”
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Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo by Yano, Kentaro, Tomono, Takumi, Sakai, Riyo, Kano, Takashi, Morimoto, Kaori, Kato, Yukio, Ogihara, Takuo

“…The ERM proteins, ezrin, radixin, and moesin, are membrane-cytoskeleton cross-linkers with multiple physiological functions. We previously showed that radixin…”
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Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats by Tomono, Takumi, Otsuka, Kyoma, Yano, Kentaro, Kanagawa, Masahiko, Arakawa, Hiroshi, Ogihara, Takuo

“…Sesamin (SM) and episesamin (ESM) are constituents of sesame seeds, which are used in health foods and considered to have various beneficial effects in the…”
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Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues by Kumagai, Hironori, Yamada, Kosuke, Nakai, Kanako, Kitamura, Tokio, Mohri, Kohta, Ukawa, Masami, Tomono, Takumi, Eguchi, Takaaki, Yoshizaki, Testuya, Fukuchi, Takumi, Yoshino, Takuya, Matsuura, Minoru, Tobita, Etsuo, Pham, Wellington, Nakase, Hiroshi, Sakuma, Shinji

“…[Display omitted] We are investigating an imaging agent for early detection of colorectal cancer. The agent, named the nanobeacon, is coumarin 6-encapsulated…”
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Alginate Enhances Excretion and Reduces Absorption of Strontium and Cesium in Rats by Idota, Yoko, Harada, Hitomi, Tomono, Takumi, Morimoto, Kaori, Kobayashi, Shoko, Kakinuma, Chihaya, Miyajima, Chihiro, Kasahara, Fumiyoshi, Ogihara, Takuo

“…Alginate (ALA), which is an intercellular polysaccharide associated with brown algae, is used as a food additive, a health food and a medicine. Here, we first…”
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P229 - P-glycoprotein activation mechanism by snail-induced epithelial-to-mesenchymal transition in lung cancer cells by Kamioka, Hiroki, Tomono, Takumi, Yano, Kentaro, Fujita, Yukiyoshi, Fujita, Atsushi, Onozato, Ryoichi, Iijima, Misa, Tsuchida, Shigeru, Arai, Takahiro, Ogihara, Takuo

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Role of P-Glycoprotein in Regulating Cilnidipine Distribution to Intact and Ischemic Brain by Yano, Kentaro, Takimoto, Shinobu, Motegi, Toshimitsu, Tomono, Takumi, Hagiwara, Mihoko, Idota, Yoko, Morimoto, Kaori, Takahara, Akira, Ogihara, Takuo

“…Cilnidipine is reported to show antihypertensive and neuroprotective actions in a rat brain ischemia model, but is barely distributed to normal brain,…”
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SPECIFIC MOLECULAR RECOGNITION AS A STRATEGY TO DELINEATE TUMOR MARGIN USING TOPICALLY APPLIED FLUORESCENCE EMBEDDED NANOPARTICLES by Barton, Shawn, Li, Bo, Siuta, Michael, Vaibhav, Janve, Song, Jessica, Holt, Clinton M, Tomono, Takumi, Ukawa, Masami, Kumagai, Hironori, Tobita, Etsuo, Wilson, Kevin, Sakuma, Shinji, Pham, Wellington

“…The Thomsen-Friedenreich (TF) antigen is a tumor-associated antigen consistently expressed on the apical surface of epithelial-based cancer cells, including…”
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Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats by Takumi Tomonoa, Kyoma Otsukab, Kentaro Yanob, Masahiko Kanagawab, Hiroshi Arakawab, Takuo Ogiharaa

“…Sesamin (SM) and episesamin (ESM) are constituents of sesame seeds, which are used in health foods and considered to have various beneficial effects in the…”
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Acquisition of absorption-enhancing abilities of cationic oligopeptides with short chain arginine residues through conjugation to hyaluronic acid by Tomono, Takumi, Yagi, Haruya, Kanemoto, Saki, Ukawa, Masami, Miyata, Kohei, Shigeno, Koichi, Sakuma, Shinji

“…[Display omitted] Cell-penetrating peptides such as oligoarginines are one of promising tools that improve mucosal absorption of poorly membrane-permeable…”
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Investigation of biopharmaceutical and physicochemical drug properties suitable for orally disintegrating tablets by Ono, Asami, Tomono, Takumi, Ogihara, Takuo, Terada, Katsuhide, Sugano, Kiyohiko

“…The purpose of this study was to evaluate the biopharmaceutical and physicochemical drug properties suitable for orally disintegrating tablets (ODTs). The…”
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