Search Results - "Tomono, Kazuo"

Novel pharmaceutical cocrystal consisting of paracetamol and trimethylglycine, a new promising cocrystal former by Maeno, Yusuke, Fukami, Toshiro, Kawahata, Masatoshi, Yamaguchi, Kentaro, Tagami, Tatsuaki, Ozeki, Tetsuya, Suzuki, Toyofumi, Tomono, Kazuo

“…[Display omitted] Paracetamol (APAP), a frequently used antipyretic drug, has poor compression moldability. In this study, we identified a novel cocrystal…”
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Determination and prediction of solubilities of active pharmaceutical ingredients in selected organic solvents by Matsuda, Hiroyuki, Mori, Kanako, Tomioka, Mariko, Kariyasu, Nozomi, Fukami, Toshiro, Kurihara, Kiyofumi, Tochigi, Katsumi, Tomono, Kazuo

“…•This study investigates measurements of solubilities of APIs.•Solubilities of APIs in different organic solvents were measured.•Solubilities of famotidine…”
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Comparison of the relative stability of pharmaceutical cocrystals consisting of paracetamol and dicarboxylic acids by Suzuki, Naoto, Kawahata, Masatoshi, Yamaguchi, Kentaro, Suzuki, Toyofumi, Tomono, Kazuo, Fukami, Toshiro

“…Objective: The aim of this study is to evaluate the relative stability of pharmaceutical cocrystals consisting of paracetamol (APAP) and oxalic acid (OXA) or…”
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Pharmaceutical evaluation of steroidal ointments by ATR-IR chemical imaging: Distribution of active and inactive pharmaceutical ingredients by Yamamoto, Yoshihisa, Fukami, Toshiro, Koide, Tatsuo, Suzuki, Toyofumi, Hiyama, Yukio, Tomono, Kazuo

“…We recently used micro attenuated total reflection infrared (ATR-IR) spectroscopy to conduct imaging analysis of ointments and evaluate the distributions of…”
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Involvement of a proton-coupled organic cation antiporter in the blood-brain barrier transport of amantadine by Suzuki, Toyofumi, Aoyama, Takahiko, Suzuki, Naoto, Kobayashi, Masaru, Fukami, Toshiro, Matsumoto, Yoshiaki, Tomono, Kazuo

“…The blood‐to‐brain transport of amantadine, a weak N‐methyl‐d‐aspartate (NMDA) antagonist, has been shown previously to participate in the cationic…”
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Comparative pharmaceutical evaluation of brand and generic clobetasone butyrate ointments by Yamamoto, Yoshihisa, Fukami, Toshiro, Koide, Tatsuo, Onuki, Yoshinori, Suzuki, Toyofumi, Metori, Koichi, Katori, Noriko, Hiyama, Yukio, Tomono, Kazuo

“…In the present study, we performed comprehensive pharmaceutical evaluation among an original clobetasone butyrate (CLB) ointment product and three generic…”
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Measurement and correlation of solubilities of the poorly water-soluble pharmaceutical compound etodolac by addition of co-solvents by Naito, Yuma, Matsuda, Hiroyuki, Shimomura, Kazuya, Kurihara, Kiyofumi, Tochigi, Katsumi, Tomono, Kazuo

“…•This study investigates solubilities of etodolac and enhancements of them by adding co-solvents.•Six cyclodextrins (CDs): α, β, γ-CD, 2-HP-β-CD, 2-HE-β-CD,…”
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Homogeneous Nanoparticles To Enhance the Efficiency of a Hydrophobic Drug, Antihyperlipidemic Probucol, Characterized by Solid-State NMR by Io, Takeshi, Fukami, Toshiro, Yamamoto, Kazutoshi, Suzuki, Toyofumi, Xu, Jiadi, Tomono, Kazuo, Ramamoorthy, Ayyalusamy

“…A low absorption in the gastrointestinal tract of hydrophobic pharmaceutical compounds in use today considerably limits their bioavailability, and therefore…”
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Pharmaceutical evaluation of atorvastatin calcium tablets available on the Internet: A preliminary investigation of substandard medicines in Japan by Fukami, Toshiro, Koide, Tatsuo, Hisada, Hiroshi, Inoue, Motoki, Yamamoto, Yoshihisa, Suzuki, Toyofumi, Tomono, Kazuo

“…Substandard medicine is a type of substandard/spurious/falsely labeled/falsified/counterfeit (SSFFC) drug as defined by the WHO that has permeated the…”
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Effects of slow-releasing colistin microspheres on endotoxin-induced sepsis by Nanjo, Yuta, Ishii, Yoshikazu, Kimura, Soichiro, Fukami, Toshiro, Mizoguchi, Masahiro, Suzuki, Toyofumi, Tomono, Kazuo, Akasaka, Yoshikiyo, Ishii, Toshiharu, Takahashi, Kazuhisa, Tateda, Kazuhiro, Yamaguchi, Keizo

“…Abstract Lipopolysaccharide (LPS) is a major contributing factor to endotoxic shock. Colistin specifically binds to LPS. However, it has the disadvantages that…”
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Studies on Uniformity of the Active Ingredients in Acetaminophen Suppositories Re-solidified after Melting under High Temperature Conditions by Yamamoto, Yoshihisa, Fukami, Toshiro, Koide, Tatsuo, Onuki, Yoshinori, Suzuki, Toyofumi, Katori, Noriko, Tomono, Kazuo

“…The target of the present pharmaceutical study was the antipyretic analgesic, acetaminophen; its suppository form is usually split when used in pediatric…”
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Effect of terpenes on the skin permeation of lomerizine dihydrochloride by Furuishi, Takayuki, Kato, Yukiko, Fukami, Toshiro, Suzuki, Toyofumi, Endo, Tomohiro, Nagase, Hiromasa, Ueda, Haruhisa, Tomono, Kazuo

“…Lomerizine dihydrochloride (LOM) is a Ca2+ channel blocker used as an antimigraine drug, which is currently administered orally in Japan. We therefore…”
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Formulation and in Vitro Evaluation of Pentazocine Transdermal Delivery System by Furuishi, Takayuki, Io, Takeshi, Fukami, Toshiro, Suzuki, Toyofumi, Tomono, Kazuo

“…The aim of this study was to prepare a pentazocine (PTZ) matrix-type transdermal drug delivery system (TDDS) using acrylic pressure-sensitive adhesives. Among…”
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Solubilities of Salicylic Acid in Pure Solvents and Binary Mixtures Containing Cosolvent by Matsuda, Hiroyuki, Kaburagi, Kenta, Matsumoto, Sho, Kurihara, Kiyofumi, Tochigi, Katsumi, Tomono, Kazuo

“…The solubility of salicylic acid in water, methanol, ethanol, ethyl acetate, polyethylene glycol (PEG) 300, and 1,4-dioxane and in various binary solvent…”
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Effect of Particle Size on Skin Permeation and Retention of Piroxicam in Aqueous Suspension by Moribe, Kunikazu, Shibata, Mizuho, Furuishi, Takayuki, Higashi, Kenjirou, Tomono, Kazuo, Yamamoto, Keiji

“…The effects of particle size on the skin permeation and retention of piroxicam (PXC) in an aqueous suspension were investigated. PXC particles of about 23 nm,…”
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Antagonism of NMDA receptors by butanesulfonyl-homospermine guanidine and neuroprotective effects in in vitro and in vivo by Masuko, Takashi, Suzuki, Toyofumi, Miyake, Muneharu, Kusama-Eguchi, Kuniko, Kizawa, Yasuo, Tomono, Kazuo, Kashiwagi, Keiko, Igarashi, Kazuei, Kusama, Tadashi

“…► Polyamine derivative, BsHSPMG inhibited strongly NMDA receptor currents. ► BsHSPMG acts deeply into the channel pore of NMDA receptors containing the…”
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Involvement of an influx transporter in the blood-brain barrier transport of naloxone by Suzuki, Toyofumi, Ohmuro, Aya, Miyata, Mariko, Furuishi, Takayuki, Hidaka, Shinji, Kugawa, Fumihiko, Fukami, Toshiro, Tomono, Kazuo

“…Naloxone, a potent and specific opioid antagonist, has been shown in previous studies to have an influx clearance across the rat blood–brain barrier (BBB) two…”
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Nanoparticle Processing in the Solid State Dramatically Increases the Cell Membrane Permeation of a Cholesterol-Lowering Drug, Probucol by Fukami, Toshiro, Ishii, Tatsuya, Io, Takeshi, Suzuki, Naoto, Suzuki, Toyofumi, Yamamoto, Kazutoshi, Xu, Jiadi, Ramamoorthy, Ayyalusamy, Tomono, Kazuo

“…High cholesterol levels (or hypercholesterolemia) are linked with many diseases, particularly with the risk of coronary heart diseases. Probucol is commonly…”
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Determination and correlation of solubilities of famotidine in water + co-solvent mixed solvents by Matsuda, Hiroyuki, Matsumoto, Sho, Kaguragi, Kenta, Kurihara, Kiyofumi, Tochigi, Katsumi, Tomono, Kazuo

“…This study aims to measure the solubilities of poorly water-soluble drugs and to enhance their solubilities by adding co-solvents. The solubilities were…”
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Characterization of multicomponent crystal formed between indomethacin and lidocaine by Umeda, Yukiko, Fukami, Toshiro, Furuishi, Takayuki, Suzuki, Toyofumi, Tanjoh, Katsuhisa, Tomono, Kazuo

“…Purpose: Crystalline complex was formed between indomethacin (IDM) and lidocaine (LDC) at molar ratio 2:1 from ethanol solution. The purpose of this study was…”
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