Search Results - "Tomoko Horisawa"

The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: Mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone by HORISAWA, Tomoko, ISHIBASHI, Tadashi, NISHIKAWA, Hiroyuki, ENOMOTO, Takeshi, TOMA, Satoko, ISHIYAMA, Takeo, TAIJI, Mutsuo

“…We have previously reported that lurasidone, a novel atypical antipsychotic with potent serotonin 5-HT(7) antagonist and 5-HT(1A) partial agonist activities,…”
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Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range by Baba, Satoko, Enomoto, Takeshi, Horisawa, Tomoko, Hashimoto, Takashi, Ono, Michiko

“…Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal…”
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The role of 5-HT7 receptor antagonism in the amelioration of MK-801-induced learning and memory deficits by the novel atypical antipsychotic drug lurasidone by Horisawa, Tomoko, Nishikawa, Hiroyuki, Toma, Satoko, Ikeda, Atsushi, Horiguchi, Masakuni, Ono, Michiko, Ishiyama, Takeo, Taiji, Mutsuo

“…► MK-801 induced cognitive deficits in passive avoidance responses in rats. ► Lurasidone, an antipsychotic with 5-HT7 antagonism, reversed the effect of…”
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Binding of lurasidone, a novel antipsychotic, to rat 5-HT7 receptor: Analysis by [3H]SB-269970 autoradiography by Horisawa, Tomoko, Ishiyama, Takeo, Ono, Michiko, Ishibashi, Tadashi, Taiji, Mutsuo

“…Lurasidone is a novel antipsychotic agent with high affinity for dopamine D2 and serotonin 5-HT7, 5-HT2A, and 5-HT1A receptors. We previously reported that in…”
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Evaluation of dopamine D2/D3 and serotonin 5-HT2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography by Nakazawa, Shunsuke, Yokoyama, Chihiro, Nishimura, Naohiro, Horisawa, Tomoko, Kawasaki, Akihiro, Mizuma, Hiroshi, Doi, Hisashi, Onoe, Hirotaka

“…Rationale Lurasidone is a novel antipsychotic drug with potent binding affinity for dopamine D 2 and serotonin (5-hydroxytryptamine, 5-HT) 2A , 5-HT 7 , and…”
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Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity by Ishibashi, Tadashi, Horisawa, Tomoko, Tokuda, Kumiko, Ishiyama, Takeo, Ogasa, Masaaki, Tagashira, Rie, Matsumoto, Kenji, Nishikawa, Hiroyuki, Ueda, Yoko, Toma, Satoko, Oki, Hitomi, Tanno, Norihiko, Saji, Ikutaro, Ito, Akira, Ohno, Yukihiro, Nakamura, Mitsutaka

“…Lurasidone [(3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl]hexahydro-4,7-methano-2H-isoindole-1,3-dione…”
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2P434 5-HT1A receptor-mediated [35S]GTP 7 S binding in Chinese Hamster Ovary (CHO) cells expressing human 5-HT1A receptors and native rat brain membranes: Effects of clozapine and perospirone by Yuji Odagaki, Yukihiro Ohno, Tomoko Horisawa, Toshio Yamauchi

“…Clozapine is a prototype of atypical antipsychotics, which elicit superior efficacy for negative or cognitive symptoms of schizophrenia to conventional…”
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5-HT1A receptor-mediated [35S]GTPγS binding in Chinese Hamster Ovary (CHO) cells expressing human 5-HT1A receptors and native rat brain membranes: Effects of clozapine and perospirone by Yuji Odagaki, Yukihiro Ohno, Tomoko Horisawa, Toshio Yamauchi

“…Clozapine is a prototype of atypical antipsychotics, which elicit superior efficacy for negative or cognitive symptoms of schizophrenia to conventional…”
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Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT1A weak partial agonistic activity showing the antidepressant-like effect by Yoshinaga, Hidefumi, Masumoto, Shuji, Koyama, Koji, Kinomura, Naoya, Matsumoto, Yuji, Kato, Taro, Baba, Satoko, Matsumoto, Kenji, Horisawa, Tomoko, Oki, Hitomi, Yabuuchi, Kazuki, Kodo, Toru

“…[Display omitted] We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1A receptor weak…”
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Structural insight into receptor-selectivity for lurasidone by Ichikawa, Osamu, Okazaki, Kazuhiko, Nakahira, Hiroyuki, Maruyama, Megumi, Nagata, Ryu, Tokuda, Kumiko, Horisawa, Tomoko, Yamazaki, Kazuto

“…► Structural models of lurasidone–GPCRs were constructed by in silico study. ► We elucidated structural features that gave lurasidone high receptor…”
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Evaluation of dopamine D sub(2)/D sub(3) and serotonin 5-HT sub(2A) receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography by Nakazawa, Shunsuke, Yokoyama, Chihiro, Nishimura, Naohiro, Horisawa, Tomoko, Kawasaki, Akihiro, Mizuma, Hiroshi, Doi, Hisashi, Onoe, Hirotaka

“…Rationale: Lurasidone is a novel antipsychotic drug with potent binding affinity for dopamine D sub(2) and serotonin (5-hydroxytryptamine, 5-HT) sub(2A), 5-HT…”
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Evaluation of dopamine D.sub.2/D.sub.3 and serotonin 5-HT.sub.2A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography by Nakazawa, Shunsuke, Yokoyama, Chihiro, Nishimura, Naohiro, Horisawa, Tomoko, Kawasaki, Akihiro, Mizuma, Hiroshi, Doi, Hisashi

“…Rationale Lurasidone is a novel antipsychotic drug with potent binding affinity for dopamine D.sub.2 and serotonin (5-hydroxytryptamine, 5-HT).sub.2A,…”
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The effects of selective antagonists of serotonin 5-HT 7 and 5-HT 1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: Mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone by Horisawa, Tomoko, Ishibashi, Tadashi, Nishikawa, Hiroyuki, Enomoto, Takeshi, Toma, Satoko, Ishiyama, Takeo, Taiji, Mutsuo

“…► MK-801 impaired passive avoidance (PA) and Morris water maze (MWM) learning in rats. ► The 5-HT 7 antagonist SB-269970 reversed the PA and MWM learning…”
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Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT 1A weak partial agonistic activity showing the antidepressant-like effect by Yoshinaga, Hidefumi, Masumoto, Shuji, Koyama, Koji, Kinomura, Naoya, Matsumoto, Yuji, Kato, Taro, Baba, Satoko, Matsumoto, Kenji, Horisawa, Tomoko, Oki, Hitomi, Yabuuchi, Kazuki, Kodo, Toru

“…We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT receptor weak partial agonistic…”
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Effects of SM-13496, an atypical antipsychotic agent, on MK-801-induced learning deficit in rats by Kumiko Tokuda, Takeo Ishiyama, Tomoko Horisawa, Satoko Toma, Yukihiro Ohno, Akira Ito

“…It is generally assumed that schizophrenia patients show cognitive impairment as well as positive symptoms and negative symptoms and that typical…”
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Potential role of 5-HT2 and D2 receptor interaction in the atypical antipsychotic action of the novel succimide derivative, perospirone by Ohno, Y, Ishida-Tokuda, K, Ishibashi, T, Sakamoto, H, Tagashira, R, Horisawa, T, Yabuuti, K, Matsumoto, K, Kawabe, A, Nakamura, M

“…The pharmacological profile of the novel serotonin-dopamine antagonists (SDA)-type antipsychotic, perospirone, was compared with other SDA and typical…”
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