Search Results - "Tomohisa Ishikawa"

Recent Progress in the Research of Insulin Secretion Foreword by Tomohisa Ishikawa

“…Pancreatic β-cells serve as a fuel sensor via secretion of insulin, which is controlled tightly by blood glucose concentration. The process of…”
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Enhanced Contraction of Arterial Smooth Muscle Cell in Skin Artery Is Sensitive to Hyperpolarization Mediated by BKCa Channel in Chronic Constriction Injury Model Rat by Ishida, Hirotake, Ishikawa, Tomohisa, Saito, Shin-ya

“…Previous our study found that improvement of skin blood flow associated with neuropathic pain using vasodilators is useful for alleviation of neuropathic pain…”
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Mechanism of Membrane Depolarization Involved in α1A-Adrenoceptor-Mediated Contraction in Rat Tail and Iliac Arteries by Ishida, Hirotake, Saito, Shin-ya, Dohi, Naoki, Ishikawa, Tomohisa

“…Our previous studies have shown that phenylephrine-induced contraction of cutaneous arteries is primarily mediated via α1A-adrenoceptors, but not…”
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Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells by Ihim, Stella Amarachi, Kaneko, Yukiko K, Yamamoto, Moe, Yamaguchi, Momoka, Kimura, Toshihide, Ishikawa, Tomohisa

“…The improvement of type 2 diabetes mellitus induced by naturally occurring polyphenols, known as flavonoids, has received considerable attention. However,…”
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Brain structural alterations and clinical features of cognitive frailty in Japanese community-dwelling older adults: the Arao study (JPSC-AD) by Yoshiura, Kazuhiro, Fukuhara, Ryuji, Ishikawa, Tomohisa, Tsunoda, Naoko, Koyama, Asuka, Miyagawa, Yusuke, Hidaka, Yosuke, Hashimoto, Mamoru, Ikeda, Manabu, Takebayashi, Minoru, Shimodozono, Megumi

“…Cognitive frailty (CF) is a clinical condition defined by the presence of both mild cognitive impairment (MCI) and physical frailty (PF). Elderly with CF are…”
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Dual effect of reduced type I diacylglycerol kinase activity on insulin secretion from MIN6 β-cells by Sawatani, Toshiaki, Kaneko, Yukiko K., Ishikawa, Tomohisa

“…The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration…”
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Dual Role of Nitric Oxide in Pancreatic β-Cells by Kaneko, Yukiko Kurohane, Ishikawa, Tomohisa

“…An involvement of inducible nitric oxide (NO) synthase (NOS) in pancreatic β-cell degeneration during the process of type 1 diabetes has been well discussed…”
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Prospective clinical intervention study of aripiprazole and risperidone in the management of postoperative delirium in elderly patients after cardiovascular surgery by Sugawara, Hiroko, Koyama, Asuka, Maruyama, Takashi, Koda, Yumiko, Fukunaga, Hiroe, Ishikawa, Tomohisa, Takebayashi, Minoru, Okamoto, Ken, Fukui, Toshihiro, Hashimoto, Mamoru

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Late-manifestation of attention-deficit/hyperactivity disorder in older adults: an observational study by Sasaki, Hiroyuki, Jono, Tadashi, Fukuhara, Ryuji, Honda, Kazuki, Ishikawa, Tomohisa, Boku, Shuken, Takebayashi, Minoru

“…The age of attention-deficit/hyperactivity disorder onset is usually during the first 12 years of life; however, there have been recent reports of late-onset…”
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Quantitative real-time measurement of endothelin-1-induced contraction in single non-activated hepatic stellate cells by Dohi, Naoki, Yamaguchi, Momoka, Hase, Reina, Suzuki, Ryosuke, Wakabayashi, Yumeto, Nishiyama, Ryota, Saito, Shin-Ya, Ishikawa, Tomohisa

“…Although quiescent hepatic stellate cells (HSCs) have been suggested to regulate hepatic blood flow, there is no direct evidence that quiescent HSCs display…”
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Caffeine-induced inversion of prostaglandin E2 effects on hepatic stellate cell activation by Yamaguchi, Momoka, Dohi, Naoki, Ooka, Akira, Saito, Shin-ya, Ishikawa, Tomohisa

“…Liver inflammation leads to the activation of hepatic stellate cells (HSCs), resulting in the development of liver fibrosis. The present study aimed to…”
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Caffeine Suppresses the Activation of Hepatic Stellate Cells cAMP-Independently by Antagonizing Adenosine Receptors by Yamaguchi, Momoka, Saito, Shin-ya, Nishiyama, Ryota, Nakamura, Misuzu, Todoroki, Kenichiro, Toyo’oka, Toshimasa, Ishikawa, Tomohisa

“…During liver injury, hepatic stellate cells (HSCs) are activated by various cytokines and transdifferentiated into myofibroblast-like activated HSCs, which…”
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Differential Contribution of Nerve-Derived Noradrenaline to High K+-Induced Contraction Depending on Type of Artery by Ishida, Hirotake, Saito, Shin-ya, Hishinuma, Eita, Ishikawa, Tomohisa

“…High K+-induced contraction of arterial smooth muscle is thought to be mediated by membrane depolarization and subsequent activation of voltage-dependent Ca2+…”
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The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion by Minami, Akira, Fujita, Yuka, Shimba, Sumika, Shiratori, Mako, Kaneko, Yukiko K., Sawatani, Toshiaki, Otsubo, Tadamune, Ikeda, Kiyoshi, Kanazawa, Hiroaki, Mikami, Yasuyo, Sekita, Risa, Kurebayashi, Yuuki, Takahashi, Tadanobu, Miyagi, Taeko, Ishikawa, Tomohisa, Suzuki, Takashi

“…Sialidase cleaves sialic acid residues from a sialoglycoconjugate: oligosaccharides, glycolipids and glycoproteins that contain sialic acid. Histochemical…”
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Renoprotective Effects of a Novel Receptor-Interacting Protein Kinase 2 Inhibitor, AS3334034, in Uninephrectomized Adriamycin-Induced Chronic Kidney Disease Rats by Wada, Yusuke, Kondo, Mitsuhiro, Sakairi, Kumi, Nagashima, Akira, Tokita, Kenichi, Tominaga, Hiroaki, Tomiyama, Hiroshi, Ishikawa, Tomohisa

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Na+-dependent inactivation of vascular Na+/Ca2+ exchanger responsible for reduced peripheral blood flow in neuropathic pain model by Ishida, Hirotake, Yamaguchi, Momoka, Saito, Shin-ya, Furukawa, Takuma, Shannonhouse, John L., Kim, Yu Shin, Ishikawa, Tomohisa

“…Reduced skin blood flow has been reported in neuropathic pain patients as well as various peripheral neuropathic pain model animals. We have previously shown…”
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Diacylglycerol Signaling Pathway in Pancreatic β-Cells: An Essential Role of Diacylglycerol Kinase in the Regulation of Insulin Secretion by Kaneko, Yukiko K., Ishikawa, Tomohisa

“…Diacylglycerol (DAG) is a lipid signal messenger and plays a physiological role in β-cells. Since defective glucose homeostasis increases de novo DAG…”
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Alleviation of mechanical stress-induced allodynia by improving blood flow in chronic constriction injury mice by Ishida, Hirotake, Saito, Shin-ya, Horie, Ayaka, Ishikawa, Tomohisa

“…Reduced blood flow in the skin is observed in patients with neuropathic pain and in animal models. The aim of the present study was to elucidate the…”
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Mental health among younger and older caregivers of dementia patients by Koyama, Asuka, Matsushita, Masateru, Hashimoto, Mamoru, Fujise, Noboru, Ishikawa, Tomohisa, Tanaka, Hibiki, Hatada, Yutaka, Miyagawa, Yusuke, Hotta, Maki, Ikeda, Manabu

“…Aim Caregiver burden in dementia is an important issue, but few studies have examined the mental health of younger and older family caregivers by comparing…”
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Clinical features of behavioral symptoms in patients with semantic dementia: Does semantic dementia cause autistic traits? by Sakuta, Shizuka, Hashimoto, Mamoru, Ikeda, Manabu, Koyama, Asuka, Takasaki, Akihiro, Hotta, Maki, Fukuhara, Ryuji, Ishikawa, Tomohisa, Yuki, Seiji, Miyagawa, Yusuke, Hidaka, Yosuke, Kaneda, Keiichiro, Takebayashi, Minoru

“…To investigate the behavioral characteristics of semantic dementia (SD) using an instrument originally developed for patients with autism spectrum disorder…”
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