Electrocardiogram with prolonged QT interval in Gitelman disease

Electrocardiogram with prolonged QT interval in Gitelman disease. Potassium and magnesium deficiency prolong the QT interval on a standard electrocardiogram and predispose the patient to dangerous cardiac arrhythmias. No information is available on QT interval in patients diagnosed with Gitelman dis...

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Bibliographic Details
Published in:	Kidney international Vol. 62; no. 2; pp. 580 - 584
Main Authors:	Bettinelli, Alberto, Tosetto, Camillo, Colussi, Giacomo, Tommasini, Ginaluca, Edefonti, Alberto, Bianchetti, Mario G.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-08-2002 Nature Publishing Elsevier Limited
Subjects:	Adolescent Adult alkalosis Alkalosis - blood Alkalosis - complications Arrhythmias, Cardiac - blood Arrhythmias, Cardiac - diagnosis Arrhythmias, Cardiac - etiology Bartter syndrome Bartter Syndrome - blood Bartter Syndrome - complications Biological and medical sciences Calcium - blood cardiac arrythmia Child electrocardiogram Electrocardiography Female Humans hypokalemia Hypokalemia - blood Hypokalemia - complications hypomagnesemia Kidneys Long QT Syndrome - blood Long QT Syndrome - diagnosis Long QT Syndrome - etiology Magnesium - blood Male Medical sciences Nephrology. Urinary tract diseases Potassium - blood sudden death Urinary system involvement in other diseases. Miscellaneous ventricular repolarization Bartter syndrome ventricular repolarization sudden death electrocardiogram hypokalemia cardiac arrythmia hypomagnesemia alkalosis Endocrinopathy Adrenal cortex diseases Hyperaldosteronism Arrhythmia Metabolic alkalosis Sex Cardiovascular disease Hyperadrenocorticism Gitelman disease Acid base balance disorder Inorganic element Electrodiagnosis Heart block Heart disease Adrenal gland diseases Electrocardiography Ratio Hypomagnesemia Kidney disease Human Urinary system disease Pathophysiology Prolonged QT interval Conduction disorder Metabolic disorder Risk factor Hypokaliemia
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Summary:	Electrocardiogram with prolonged QT interval in Gitelman disease. Potassium and magnesium deficiency prolong the QT interval on a standard electrocardiogram and predispose the patient to dangerous cardiac arrhythmias. No information is available on QT interval in patients diagnosed with Gitelman disease. The QT interval was assessed on lead II in 27 patients with biochemically and genetically defined Gitelman disease, who had discontinued medical treatment for at least four weeks. They included 15 female and 12 male subjects, aged 6.7 to 40 years old, median 20 years old. The corrected QT interval was calculated from the measured QT interval and heart rate using the Bazett formula. The corrected QT interval was normal (between 391 and 433 msec) in 16 and prolonged in the remaining 11 patients (between 444 and 504 msec). Patients with prolonged and patients with normal QT interval did not significantly differ with respect to female to male ratio, plasma potassium, plasma total magnesium, and plasma ionized calcium. Plasma sodium and chloride values were slightly but significantly lower and bicarbonate levels higher in patients with a prolonged than in those with a normal QT interval. The corrected QT interval is often pathologically prolonged in patients with Gitelman disease, suggesting that there is an increased risk for development of dangerous arrhythmias. Further investigations are required in patients with a prolonged QT interval to assess the true hazard of dangerous arrhythmias.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0085-2538 1523-1755
DOI:	10.1046/j.1523-1755.2002.00467.x