Search Results - "Tommasi, Stella"

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer by Caliri, Andrew W., Tommasi, Stella, Besaratinia, Ahmad

“…[Display omitted] •Oxidative stress is a key contributor to both cancer and inflammatory diseases.•Smoking-induced ROS can damage macromolecular…”
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Exploring the Utility of Long Non-Coding RNAs for Assessing the Health Consequences of Vaping by Besaratinia, Ahmad, Blumenfeld, Hannah, Tommasi, Stella

“…Electronic cigarette (e-cig) use, otherwise known as "vaping", is widespread among adolescent never-smokers and adult smokers seeking a less-harmful…”
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DNA Hydroxymethylation in Smoking-Associated Cancers by Besaratinia, Ahmad, Caceres, Amanda, Tommasi, Stella

“…5-hydroxymethylcytosine (5-hmC) was first detected in mammalian DNA five decades ago. However, it did not take center stage in the field of epigenetics until…”
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The Untapped Biomarker Potential of MicroRNAs for Health Risk-Benefit Analysis of Vaping vs. Smoking by Besaratinia, Ahmad, Tommasi, Stella

“…Despite the popularity of electronic cigarettes (e-cigs) among adolescent never-smokers and adult smokers seeking a less pernicious substitute for tobacco…”
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The consequential impact of JUUL on youth vaping and the landscape of tobacco products: The state of play in the COVID-19 era by Besaratinia, Ahmad, Tommasi, Stella

“…•JUUL is an innovative e-cig and the preeminent vaping product on the market.•JUUL has played a key role in the ongoing epidemic of youth vaping.•JUUL has had…”
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Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers by Caliri, Andrew W., Caceres, Amanda, Tommasi, Stella, Besaratinia, Ahmad

“…The outbreak of vaping-related severe lung injuries and deaths and the epidemic of teen vaping in the U.S. underscore the urgent need for determining the…”
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Secondhand smoke affects reproductive functions by altering the mouse testis transcriptome, and leads to select intron retention in Pde1a by Tommasi, Stella, Kitapci, Tevfik H., Blumenfeld, Hannah, Besaratinia, Ahmad

“…[Display omitted] •There is a paucity of data on the effects of SHS on the male reproductive system.•We investigated the effects of SHS on the testis…”
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Secondhand Smoke Induces Liver Steatosis through Deregulation of Genes Involved in Hepatic Lipid Metabolism by Tommasi, Stella, Yoon, Jae-In, Besaratinia, Ahmad

“…We investigated the role of secondhand smoke (SHS) exposure, independently of diet, in the development of chronic liver disease. Standard diet-fed mice were…”
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A novel role for vaping in mitochondrial gene dysregulation and inflammation fundamental to disease development by Tommasi, Stella, Pabustan, Niccolo, Li, Meng, Chen, Yibu, Siegmund, Kimberly D., Besaratinia, Ahmad

“…We constructed and analyzed the whole transcriptome in leukocytes of healthy adult vapers (with/without a history of smoking), ‘exclusive’ cigarette smokers,…”
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Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users by Tommasi, Stella, Caliri, Andrew W, Caceres, Amanda, Moreno, Debra E, Li, Meng, Chen, Yibu, Siegmund, Kimberly D, Besaratinia, Ahmad

“…We have investigated the regulation of genes and associated molecular pathways, genome-wide, in oral cells of electronic cigarette (e-cigs) users and cigarette…”
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Alterations of DNA methylome in human bladder cancer by Besaratinia, Ahmad, Cockburn, Myles, Tommasi, Stella

“…Bladder cancer is the fourth most common cancer in men in the United States, and its recurrence rate is highest among all malignancies. The unmet need for…”
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Epigenetics of human melanoma： promises and challenges by Besaratinia, Ahmad, Tommasi, Stella

“…Melanoma is the deadliest form of skin cancer with rising incidence and mortality rates. Although early-stage melanoma is highly curable, advanced-stage…”
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Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer by Tommasi, Stella, Karm, Deborah L, Wu, Xiwei, Yen, Yun, Pfeifer, Gerd P

“…Aberrant methylation of CpG islands is a hallmark of cancer and occurs at an early stage in breast tumorigenesis. However, its impact on tumor development is…”
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RASSF1A Is Part of a Complex Similar to the Drosophila Hippo/Salvador/Lats Tumor-Suppressor Network by Guo, Cai, Tommasi, Stella, Liu, Limin, Yee, Jiing-Kuan, Dammann, Reinhard, Pfeifer, Gerd P.

“…The Ras Association Domain Family 1A ( RASSF1A) gene is one of the most frequently silenced genes in human cancer. RASSF1A has been shown to interact with the…”
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Mutation Analysis in Cultured Cells of Transgenic Rodents by Besaratinia, Ahmad, Zheng, Albert, Bates, Steven E, Tommasi, Stella

“…To comply with guiding principles for the ethical use of animals for experimental research, the field of mutation research has witnessed a shift of interest…”
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A high-throughput next-generation sequencing-based method for detecting the mutational fingerprint of carcinogens by Besaratinia, Ahmad, Li, Haiqing, Yoon, Jae-In, Zheng, Albert, Gao, Hanlin, Tommasi, Stella

“…Many carcinogens leave a unique mutational fingerprint in the human genome. These mutational fingerprints manifest as specific types of mutations often…”
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Identification of 5 novel genes methylated in breast and other epithelial cancers by Hill, Victoria K, Hesson, Luke B, Dansranjavin, Temuujin, Dallol, Ashraf, Bieche, Ivan, Vacher, Sophie, Tommasi, Stella, Dobbins, Timothy, Gentle, Dean, Euhus, David, Lewis, Cheryl, Dammann, Reinhard, Ward, Robyn L, Minna, John, Maher, Eammon R, Pfeifer, Gerd P, Latif, Farida

“…There are several high throughput approaches to identify methylated genes in cancer. We utilized one such recently developed approach, MIRA (methylated-CpG…”
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Tumor susceptibility of Rassf1a knockout mice by Tommasi, Stella, Dammann, Reinhard, Zhang, Zhongqiu, Wang, Yian, Liu, Limin, Tsark, Walter M, Wilczynski, Sharon P, Li, Jie, You, Ming, Pfeifer, Gerd P

“…The human Ras association domain family 1 (RASSF1) gene is located at 3p21.3 in an area that is believed to harbor at least one important tumor suppressor…”
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Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells by Castanotto, Daniela, Tommasi, Stella, Li, Mingjie, Li, Haitang, Yanow, Stephanie, Pfeifer, Gerd P, Rossi, John J

“…Methylation of cytosines in CpG motifs is an important mechanism for epigenetic regulation of gene expression in mammalian cells. The initiating event(s) for…”
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New experimental data linking secondhand smoke exposure to lung cancer in nonsmokers by Kim, Sang‐In, Yoon, Jae‐In, Tommasi, Stella, Besaratinia, Ahmad

“…Secondhand smoke (SHS) exposure is a known risk factor for lung cancer development in lifelong nonsmokers; however, the mechanistic involvement of SHS in the…”
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