Search Results - "Tomlinson, Jennifer H."

Characterization of Salt Bridges to Lysines in the Protein G B1 Domain by Tomlinson, Jennifer H, Ullah, Saif, Hansen, Poul Erik, Williamson, Mike P

“…NMR investigations have been carried out on the B1 domain of protein G. This protein has six lysine residues, of which three are consistently found to form…”
Get full text

Structural origins of pH-dependent chemical shifts in the B1 domain of protein G by Tomlinson, Jennifer H., Green, Victoria L., Baker, Patrick J., Williamson, Mike P.

“…We report chemical shifts for HN, N, and C′ nuclei in the His‐tagged B1 domain of protein G (GB1) over a range of pH values from pH 2.0 to 9.0, which fit well…”
Get full text

Fusidic acid resistance through changes in the dynamics of the drug target by Tomlinson, Jennifer H., Kalverda, Arnout P., Calabrese, Antonio N.

“…Antibiotic resistance in clinically important bacteria can be mediated by target protection mechanisms, whereby a protein binds to the drug target and protects…”
Get full text

Amide temperature coefficients in the protein G B1 domain by Tomlinson, Jennifer H., Williamson, Mike P.

“…Temperature coefficients have been measured for backbone amide 1 H and 15 N nuclei in the B1 domain of protein G (GB1), using temperatures in the range…”
Get full text

A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance by Tomlinson, Jennifer H., Thompson, Gary S., Kalverda, Arnout P., Zhuravleva, Anastasia, O’Neill, Alex J.

“…Antibiotic resistance in clinically important bacteria can be mediated by proteins that physically associate with the drug target and act to protect it from…”
Get full text

A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus by Gupta, Arya, Monteferrante, Carmine, Rasina, Dace, Leitis, Gundars, Randall, Christopher P, Tomlinson, Jennifer H, Jirgensons, Aigars, Goessens, Wil H F, Hays, John P, O'Neill, Alex J

“…GSK2251052 is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS) that has been evaluated in phase II clinical trials. Here, we report…”
Get full text

Dimerization of protein G B1 domain at low pH: A conformational switch caused by loss of a single hydrogen bond by Tomlinson, Jennifer H., Craven, C. Jeremy, Williamson, Mike P., Pandya, Maya J.

“…A number of signals in the NMR spectrum of the B1 domain of staphylococcal protein G (GB1) show a chemical shift dependence on the concentration of the protein…”
Get full text