Search Results - "Tomlinson, E.S."

Dexamethasone metabolism in vitro: Species differences by Tomlinson, E.S., Maggs, J.L., Park, B.K., Back, D.J.

“…Dexamethasone (DEX) is extensively metabolized to 6-hydroxyDEX (6OH-DEX) and side-chain cleaved metabolites in human liver both in vitro and in vivo with…”
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A phase IB study of ABT-751 in combination with docetaxel in patients with advanced castration-resistant prostate cancer by Michels, J., Ellard, S.L., Le, L., Kollmannsberger, C., Murray, N., Tomlinson Guns, E.S., Carr, R., Chi, K.N.

“…This study investigated the safety, pharmacokinetics (PK) and clinical antitumor activity of ABT-751, a novel sulfonamide antimitotic and vascular disrupting…”
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In vitro metabolism of dexamethasone (DEX) in human liver and kidney: The involvement of CYP3a4 and CYP17 (17,20 LYASE) and molecular modelling studies by Tomlinson, E.S., Lewis, D.F.V., Maggs, J.L., Kroemer, H.K., Park, B.K., Back, D.J.

“…Dexamethasone (DEX) has previously been shown to be extensively metabolised to 6-hydroxylated and side-chain cleaved metabolites in human liver in vitro…”
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