Search Results - "Tomlinson, D. C."

FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer by Tomlinson, DC, Baldo, O, Harnden, P, Knowles, MA

“…FGFR3 is frequently activated by mutation in urothelial carcinoma (UC) and represents a potential target for therapy. In multiple myeloma, both over-expression…”
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Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo by Lamont, F R, Tomlinson, D C, Cooper, P A, Shnyder, S D, Chester, J D, Knowles, M A

“…Background: Activating mutations of FGFR3 are frequently identified in superficial urothelial carcinoma (UC) and increased expression of FGFR1 and FGFR3 are…”
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Mechanisms of FGFR3 actions in endocrine resistant breast cancer by Tomlinson, D.C., Knowles, M.A., Speirs, V.

“…Although endocrine therapy has dramatically improved the treatment of breast cancer therapeutic resistance and tumour recurrence occurs, even in estrogen…”
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Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner by di Martino, E, L'Hôte, C G, Kennedy, W, Tomlinson, D C, Knowles, M A

“…Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in bladder tumors, little information is available on their specific…”
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Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer by TOMLINSON, D. C, HURST, C. D, KNOWLES, M. A

“…More than 60% of low-grade non-invasive papillary urothelial cell carcinomas contain activating point mutations of fibroblast growth factor receptor 3 (FGFR3)…”
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Label-free electrochemical impedance biosensor to detect human interleukin-8 in serum with sub-pg/ml sensitivity by Sharma, R., Deacon, S.E., Nowak, D., George, S.E., Szymonik, M.P., Tang, A.A.S., Tomlinson, D.C., Davies, A.G., McPherson, M.J., Wälti, C.

“…Biosensors with high sensitivity and short time-to-result that are capable of detecting biomarkers in body fluids such as serum are an important prerequisite…”
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Profiling cytotoxic microRNAs in pediatric and adult glioblastoma cells by high-content screening, identification, and validation of miR-1300 by Boissinot, M., King, H., Adams, M., Higgins, J., Shaw, G., Ward, T. A., Steele, L. P., Tams, D., Morton, R., Polson, E., da Silva, B., Droop, A., Hayes, J. L., Martin, H., Laslo, P., Morrison, E., Tomlinson, D. C., Wurdak, H., Bond, J., Lawler, S. E., Short, S. C.

“…MicroRNAs play an important role in the regulation of mRNA translation and have therapeutic potential in cancer and other diseases. To profile the landscape of…”
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Tumor heterogeneity of fibroblast growth factor receptor 3 (FGFR3) mutations in invasive bladder cancer: implications for perioperative anti-FGFR3 treatment by Pouessel, D., Neuzillet, Y., Mertens, L.S., van der Heijden, M.S., de Jong, J., Sanders, J., Peters, D., Leroy, K., Manceau, A., Maille, P., Soyeux, P., Moktefi, A., Semprez, F., Vordos, D., de la Taille, A., Hurst, C.D., Tomlinson, D.C., Harnden, P., Bostrom, P.J., Mirtti, T., Horenblas, S., Loriot, Y., Houédé, N., Chevreau, C., Beuzeboc, P., Shariat, S.F., Sagalowsky, A.I., Ashfaq, R., Burger, M., Jewett, M.A.S., Zlotta, A.R., Broeks, A., Bapat, B., Knowles, M.A., Lotan, Y., van der Kwast, T.H., Culine, S., Allory, Y., van Rhijn, B.W.G.

“…Fibroblast growth factor receptor 3 (FGFR3) is an actionable target in bladder cancer. Preclinical studies show that anti-FGFR3 treatment slows down tumor…”
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Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplification by Hurst, C D, Tomlinson, D C, Williams, S V, Platt, F M, Knowles, M A

“…E2F3 and CDKAL1 are candidate genes from the 6p22 region frequently amplified in bladder cancer. Expression of E2F3 isoforms (E2F3a and b) and CDKAL1 were…”
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FGFR3 and ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma by JEBAR, Adel H, HURST, Carolyn D, TOMLINSON, Darren C, JOHNSTON, Colin, TAYLOR, Claire F, KNOWLES, Margaret A

“…Fibroblast growth factor receptor 3 (FGFR3) mutations are frequent in superficial urothelial cell carcinoma (UCC). Ras gene mutations are also found in UCC. As…”
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The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function by Stadler, L K J, Tomlinson, D C, Lee, T, Knowles, M A, Ko Ferrigno, P

“…The B-cell CLL/lymphoma-2 (Bcl-2) family of proteins are important regulators of the intrinsic pathway of apoptosis, and their interactions, driven by Bcl-2…”
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The phenotype of recovery VIII: Association among delay discounting, recovery capital, and length of abstinence among individuals in recovery from substance use disorders by Keith, D.R., Tegge, A.N., Athamneh, L.N., Freitas-Lemos, R., Tomlinson, D.C., Craft, W.H., Bickel, W.K.

“…Research defines recovery capital as the amount of tangible and intangible resources (e.g., human/personal, physical, social, and cultural) available to…”
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Chapter Eight - Ubiquitin-Mediated Regulation of Cellular Responses to Vascular Endothelial Growth Factors by Smith, G A, Tomlinson, D C, Harrison, M A, Ponnambalam, S

“…Vascular endothelial growth factors (VEGFs) bind receptor tyrosine kinases (VEGFRs) to regulate vascular and lymphatic development and homeostasis. Such…”
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Sonic hedgehog regulates prostatic growth and epithelial differentiation by Freestone, Sarah H, Marker, Paul, Grace, O.Cathal, Tomlinson, Darren C, Cunha, Gerald R, Harnden, Patricia, Thomson, Axel A

“…The Sonic hedgehog (SHH)-signalling pathway mediates epithelial–mesenchymal interactions in several tissues during development and disease, and we have…”
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5068A novel methodology to improve prolonged clot lysis in diabetes by Schutt, K A, King, R A, Tiede, C, Jankowski, V, John, V, Trehan, A, Simmons, K, Ponnambalam, S, Fishwick, C W G, McPherson, M J, Tomlinson, D C, Ajjan, R A

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P01.01 Ectopic expression of microRNA-1300 in adult and paediatric glioma cells induces cytokinesis failure and apoptosis via ECT2 by Boissinot, M., King, H., Adams, M., Higgins, J., Steele, L. P., Wurdak, H., Bond, J., Tomlinson, D. C., Lawler, S. E., Short, S. C.

“…MicroRNAs are proving to be potent tumour suppressors in cancer. Many microRNAs are in pre-clinical and clinical validation. A high-throughput screen was…”
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The use of nanoelectronic devices in highly parallel computing systems by Fountain, T.J., Duff, M.J.B., Crawley, D.G., Tomlinson, C.D., Moffat, C.D.

“…The continuing development of smaller electronic devices into the nanoelectronic regime offers great possibilities for the construction of highly parallel…”
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Multidrug-resistant breast cancer: current perspectives by Martin, Heather L, Smith, Laura, Tomlinson, Darren C

“…Breast cancer is the most common cancer in women worldwide, and resistance to the current therapeutics, often concurrently, is an increasing clinical…”
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Inactivation of the Rb pathway and overexpression of both isoforms of E2F3 are obligate events in bladder tumours with 6p22 amplificationf by Hurst, C D, Tomlinson, D C, Williams, S V, Platt, F M, Knowles, M A

“…E2F3 and CDKAL1 are candidate genes from the 6p22 region frequently amplified in bladder cancer. Expression of E2F3 isoforms (E2F3a and b) and CDKAL1 were…”
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Abstract P6-02-06: A 3D tri-culture model of normal mammary gland. A tool for breast cancer initiation studies by Nash, CE, Holliday, DL, Mavria, G, Tomlinson, DC, Hanby, AM, Speirs, V

“…Abstract The mechanisms involved in breast cancer initiation are not well understood. This may in part be due to a lack of an in vitro model that faithfully…”
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