Search Results - "Tomlins, SA"

Cellular and Genetic Causes of Idiopathic Hyperaldosteronism by Omata, Kei, Satoh, Fumitoshi, Morimoto, Ryo, Ito, Sadayoshi, Yamazaki, Yuto, Nakamura, Yasuhiro, Anand, Sharath K, Guo, Zeng, Stowasser, Michael, Sasano, Hironobu, Tomlins, Scott A, Rainey, William E

“…Primary aldosteronism affects ≈5% to 10% of hypertensive patients and has unilateral and bilateral forms. Most unilateral primary aldosteronism is caused by…”
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Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers. I. Molecular Biomarkers in Prostate Cancer by Lotan, Tamara L., Tomlins, Scott A., Bismar, Tarek A., Van der Kwast, Theodorus H., Grignon, David, Egevad, Lars, Kristiansen, Glen, Pritchard, Colin C., Rubin, Mark A., Bubendorf, Lukas

“…The combined clinical and molecular heterogeneity of prostate cancer necessitates the use of prognostic, predictive, and diagnostic biomarkers to assist the…”
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Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer by Tomlins, Scott A., Rhodes, Daniel R., Perner, Sven, Dhanasekaran, Saravana M., Mehra, Rohit, Sun, Xiao-Wei, Varambally, Sooryanarayana, Cao, Xuhong, Tchinda, Joelle, Kuefer, Rainer, Lee, Charles, Montie, James E., Shah, Rajal B., Pienta, Kenneth J., Rubin, Mark A., Chinnaiyan, Arul M.

“…Recurrent chromosomal rearrangements have not been well characterized in common carcinomas. We used a bioinformatics approach to discover candidate oncogenic…”
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Antibody-Based Detection of ERG Rearrangement-Positive Prostate Cancer by Park, Kyung, Tomlins, Scott A., Mudaliar, Kumaran M., Chiu, Ya-Lin, Esgueva, Raquel, Mehra, Rohit, Suleman, Khalid, Varambally, Sooryanarayana, Brenner, John C., MacDonald, Theresa, Srivastava, Abhishek, Tewari, Ashutosh K., Sathyanarayana, Ubaradka, Nagy, Dea, Pestano, Gary, Kunju, Lakshmi P., Demichelis, Francesca, Chinnaiyan, Arul M., Rubin, Mark A.

“…TMPRSS2-ERG gene fusions occur in 50% of prostate cancers and result in the overexpression of a chimeric fusion transcript that encodes a truncated ERG…”
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Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression by Varambally, Sooryanarayana, Yu, Jianjun, Laxman, Bharathi, Rhodes, Daniel R., Mehra, Rohit, Tomlins, Scott A., Shah, Rajal B., Chandran, Uma, Monzon, Federico A., Becich, Michael J., Wei, John T., Pienta, Kenneth J., Ghosh, Debashis, Rubin, Mark A., Chinnaiyan, Arul M.

“…Molecular profiling of cancer at the transcript level has become routine. Large-scale analysis of proteomic alterations during cancer progression has been a…”
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Probabilistic model of the human protein-protein interaction network by Chinnaiyan, Arul M, Rhodes, Daniel R, Tomlins, Scott A, Varambally, Sooryanarayana, Mahavisno, Vasudeva, Barrette, Terrence, Kalyana-Sundaram, Shanker, Ghosh, Debashis, Pandey, Akhilesh

“…A catalog of all human protein-protein interactions would provide scientists with a framework to study protein deregulation in complex diseases such as cancer…”
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Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (tarceva) by CHINNAIYAN, Prakash, HUANG, Shyhmin, VALLABHANENI, Geetha, ARMSTRONG, Eric, VARAMBALLY, Sooryanarayana, TOMLINS, Scott A, CHINNAIYAN, Arul M, HARARI, Paul M

“…Erlotinib (Tarceva) is an orally available HER1 (epidermal growth factor receptor, EGFR) tyrosine kinase inhibitor advancing through clinical trials for the…”
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TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer by TOMLINS, Scott A, MEHRA, Rohit, CHINNAIYAN, Arul M, RHODES, Daniel R, SMITH, Lisa R, ROULSTON, Diane, HELGESON, Beth E, XUHONG CAO, WEI, John T, RUBIN, Mark A, SHAH, Rajal B

“…Although common in hematologic and mesenchymal malignancies, recurrent gene fusions have not been well characterized in epithelial carcinomas. Recently, using…”
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The Role of SPINK1 in ETS Rearrangement-Negative Prostate Cancers by Tomlins, Scott A., Rhodes, Daniel R., Yu, Jianjun, Varambally, Sooryanarayana, Mehra, Rohit, Perner, Sven, Demichelis, Francesca, Helgeson, Beth E., Laxman, Bharathi, Morris, David S., Cao, Qi, Cao, Xuhong, Andrén, Ove, Fall, Katja, Johnson, Laura, Wei, John T., Shah, Rajal B., Al-Ahmadie, Hikmat, Eastham, James A., Eggener, Scott E., Fine, Samson W., Hotakainen, Kristina, Stenman, Ulf-Håkan, Tsodikov, Alex, Gerald, William L., Lilja, Hans, Reuter, Victor E., Kantoff, Phillip W., Scardino, Peter T., Rubin, Mark A., Bjartell, Anders S., Chinnaiyan, Arul M.

“…ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we…”
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Integrative Genomics Analysis Reveals Silencing of β-Adrenergic Signaling by Polycomb in Prostate Cancer by Yu, Jindan, Cao, Qi, Mehra, Rohit, Laxman, Bharathi, Yu, Jianjun, Tomlins, Scott A., Creighton, Chad J., Dhanasekaran, Saravana M., Shen, Ronglai, Chen, Guoan, Morris, David S., Marquez, Victor E., Shah, Rajal B., Ghosh, Debashis, Varambally, Sooryanarayana, Chinnaiyan, Arul M.

“…The Polycomb group (PcG) protein EZH2 possesses oncogenic properties for which the underlying mechanism is unclear. We integrated in vitro cell line, in vivo…”
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EZH2 Is a Marker of Aggressive Breast Cancer and Promotes Neoplastic Transformation of Breast Epithelial Cells by Kleer, Celina G., Cao, Qi, Varambally, Sooryanarayana, Shen, Ronglai, Ota, Ichiro, Tomlins, Scott A., Ghosh, Debashis, Richard G. A. B. Sewalt, Otte, Arie P., Hayes, Daniel F., Sabel, Michael S., Livant, Donna, Weiss, Stephen J., Rubin, Mark A., Chinnaiyan, Arul M.

“…The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive prostate cancer. Here…”
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Transcriptomic heterogeneity in multifocal prostate cancer by Salami, Simpa S, Hovelson, Daniel H, Kaplan, Jeremy B, Mathieu, Romain, Udager, Aaron M, Curci, Nicole E, Lee, Matthew, Plouffe, Komal R, de la Vega, Lorena Lazo, Susani, Martin, Rioux-Leclercq, Nathalie, Spratt, Daniel E, Morgan, Todd M, Davenport, Matthew S, Chinnaiyan, Arul M, Cyrta, Joanna, Rubin, Mark A, Shariat, Shahrokh F, Tomlins, Scott A, Palapattu, Ganesh S

“…Commercial gene expression assays are guiding clinical decision making in patients with prostate cancer, particularly when considering active surveillance…”
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Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo by Masumoto, Junya, Yang, Kangkang, Varambally, Sooryanarayana, Hasegawa, Mizuho, Tomlins, Scott A, Qiu, Su, Fujimoto, Yukari, Kawasaki, Akiko, Foster, Simon J, Horie, Yasuo, Mak, Tak W, Núñez, Gabriel, Chinnaiyan, Arul M, Fukase, Koichi, Inohara, Naohiro

“…Nod1 is a member of family of intracellular proteins that mediate host recognition of bacterial peptidoglycan. To characterize immune responses mediated by…”
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FIZZ1 Stimulation of Myofibroblast Differentiation by Liu, Tianju, Dhanasekaran, Saravana M., Jin, Hong, Hu, Biao, Tomlins, Scott A., Chinnaiyan, Arul M., Phan, Sem H.

“…Bleomycin-induced pulmonary fibrosis is characterized by inflammation, emergence of myofibroblasts, and deposition of extracellular matrix. In an attempt to…”
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Abstract P2-02-19: Somatic genetic profiling of circulating tumor cells (CTC) in metastatic breast cancer (MBC) patients by Paoletti, C, Cani, AK, Aung, K, Darga, EP, Cannell, EM, Hovelson, DH, Yazdani, M, Blevins, AR, Tokudome, N, Larios, JM, Thomas, DG, Brown, ME, Gersch, C, Schott, AF, Robinson, DR, Chinnaiyan, AM, Bischoff, F, Hayes, DF, Rae, JM, Tomlins, SA

“…Introduction: Somatic mutations, including those in TP53, PIK3CA, and estrogen receptor alpha (ESR1), are key to the biology of cancer and response to therapy…”
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Overexpression, amplification, and androgen regulation of TPD52 in prostate cancer by RUBIN, Mark A, VARAMBALLY, Sooryanarayana, HSI, Bae-Li, BYRNE, Jennifier A, PIENTA, Kenneth J, COLLINS, Colin, SELLERS, William R, CHINNAIYAN, Arul M, BEROUKHIM, Rameen, TOMLINS, Scott A, RHODES, Daniel R, PARIS, Pamela L, HOFER, Matthias D, STORZ-SCHWEIZER, Martina, KUEFER, Rainer, FLETCHER, Jonathan A

“…Gains in the long arm of chromosome 8 (8q) are believed to be associated with poor outcome and the development of hormone-refractory prostate cancer. Based on…”
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Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty by Dhanasekaran, Saravana Mohan, Dash, Atreya, Yu, Jianjun, Maine, Ira P, Laxman, Bharathi, Tomlins, Scott A, Creighton, Chad J, Menon, Anjana, Rubin, Mark A, Chinnaiyan, Arul M

“…ABSTRACT Testosterone production surges during puberty and orchestrates massive growth and reorganization of the prostate gland, and this glandular…”
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Role of Transcriptional Co-Repressor CtBP1 in Prostate Cancer Progression by Wang, R, Asangani, IA, Chakravarthi, BVSK, Ateeq, B, Lonigro, R J, Cao, Q, Mani, R-S, Camacho, D F, McGregor, N, Schumann, TEW, Jing, X, Menawat, R, Tomlins, SA, Zheng, H

“…Transcriptional repressors and co-repressors play a critical role in cellular homeostasis and are frequently altered in cancer. C-terminal Binding Protein 1…”
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Elevated α-Methylacyl-CoA Racemase Enzymatic Activity in Prostate Cancer by Kumar-Sinha, Chandan, Shah, Rajal B., Laxman, Bharathi, Tomlins, Scott A., Harwood, Jason, Schmitz, Werner, Conzelmann, Ernst, Sanda, Martin G., Wei, John T., Rubin, Mark A., Chinnaiyan, Arul M.

“…α-Methylacyl-CoA racemase (AMACR) is a peroxisomal and mitochondrial enzyme involved in the β-oxidation of branched fatty acids, shown to be elevated in…”
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Enhancing the antitumor activity of ErbB blockade with histone deacetylase (HDAC) inhibition by Chinnaiyan, Prakash, Varambally, Sooryanarayana, Tomlins, Scott A., Ray, Soma, Huang, Shyhmin, Chinnaiyan, Arul M., Harari, Paul M.

“…Molecular inhibition of the ErbB signaling pathway represents a promising cancer treatment strategy. Preclinical studies suggest that enhancement of antitumor…”
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