Search Results - "Tomkinson, A E"

Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species by Izumi, Tadahide, Hazra, Tapas K., Boldogh, Istvan, Tomkinson, Alan E., Park, Min S., Ikeda, Shogo, Mitra, Sankar

“…The major mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) plays a central role in the DNA base excision repair pathway (BER) in two distinct ways. As…”
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Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias by Tobin, L A, Robert, C, Rapoport, A P, Gojo, I, Baer, M R, Tomkinson, A E, Rassool, F V

“…Resistance to imatinib (IM) and other tyrosine kinase inhibitors (TKI)s is an increasing problem in leukemias caused by expression of BCR-ABL1. As chronic…”
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Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease by Bardwell, A.J, Bardwell, L, Tomkinson, A.E, Friedberg, E.C

“…The RAD1 and RAD10 genes of Saccharomyces cerevisiae are required for both nucleotide excision repair and certain mitotic recombination events. Here, model…”
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An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination by Mackey, Zachary B., Ramos, William, Levin, David S., Walter, Christi A., McCarrey, John R., Tomkinson, Alan E.

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Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents by Barnes, D E, Tomkinson, A E, Lehmann, A R, Webster, A D, Lindahl, T

“…Two missense mutations occurring in different alleles of the DNA ligase I gene, encoding the major DNA ligase in proliferating mammalian cells, were detected…”
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Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells by Tomkinson, A E, Bonk, R T, Linn, S

“…Endonuclease activity which specifically cleaves baseless (apurinic/apyrimidinic (AP] sites in supercoiled DNA has been purified from mitochondria of the mouse…”
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Mechanism of DNA double-strand break repair by non-homologous end joining by Hefferin, Melissa L., Tomkinson, Alan E.

“…The repair of DNA double-strand breaks (DSBs) is critical for maintaining genome stability. Although the non-homologous end joining (NHEJ) pathway frequently…”
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Yeast DNA repair and recombination proteins Rad1 and Rad10 constitute a single-stranded-DNA endonuclease by Tomkinson, A.E, Bardwell, A.J, Bardwell, L, Tappe, N.J, Friedberg, E.C

“…Damage-specific recognition and incision of DNA during nucleotide excision repair in yeast and mammalian cells requires multiple gene products. Amino-acid…”
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AP Endonuclease-Independent DNA Base Excision Repair in Human Cells by Wiederhold, Lee, Leppard, John B, Kedar, Padmini, Karimi-Busheri, Feridoun, Rasouli-Nia, Aghdass, Weinfeld, Michael, Tomkinson, Alan E, Izumi, Tadahide, Prasad, Rajendra, Wilson, Samuel H, Mitra, Sankar, Hazra, Tapas K

“…The paradigm for repair of oxidized base lesions in genomes via the base excision repair (BER) pathway is based on studies in Escherichia coli, in which AP…”
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Location of the Active Site for Enzyme-Adenylate Formation in DNA Ligases by Tomkinson, Alan E., Totty, Nicholas F., Ginsburg, Michele, Lindahl, Tomas

“…The enzyme-AMP reaction intermediate of the 102-kDa bovine DNA ligase I was digested with trypsin, and the adenylylated peptide was isolated by chromatography…”
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Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination by Chen, Jingwen, Tomkinson, Alan E., Ramos, William, Mackey, Zachary B., Danehower, Sue, Walter, Christi A., Schultz, Roger A., Besterman, Jeffrey M., Husain, Intisar

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Physical and Functional Interaction between DNA Ligase IIIα and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair by Leppard, John B., Dong, Zhiwan, Mackey, Zachary B., Tomkinson, Alan E.

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Three distinct DNA ligases in mammalian cells by TOMKINSON, A. E, ROBERTS, E, DALY, G, TOTTY, N. F, LINDAHL, T

“…The major DNA ligase of proliferating mammalian cells, DNA ligase I, catalyzes the joining of single strand breaks in double stranded DNA and is active on a…”
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Mammalian DNA ligases. Catalytic domain and size of DNA ligase I by TOMKINSON, A. E, LASKO, D. D, DALY, G, LINDAHL, T

“…DNA ligase I is the major DNA ligase activity in proliferating mammalian cells. The protein has been purified to apparent homogeneity from calf thymus. It has…”
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Interactions of the DNA Ligase IV-XRCC4 Complex with DNA Ends and the DNA-dependent Protein Kinase by Chen, L, Trujillo, K, Sung, P, Tomkinson, A E

“…The DNA-dependent protein kinase (DNA-PK), consisting of Ku and the DNA-PK catalytic subunit (DNA-PKcs), and the DNA ligase IV-XRCC4 complex function together…”
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Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps by Srivastava, D K, Berg, B J, Prasad, R, Molina, J T, Beard, W A, Tomkinson, A E, Wilson, S H

“…Base excision repair (BER) is one of the cellular defense mechanisms repairing damage to nucleoside 5'-monophosphate residues in genomic DNA. This repair…”
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Human DNA Ligase I cDNA: Cloning and Functional Expression in Saccharomyces cerevisiae by Barnes, Deborah E., Johnston, Leland H., Kodama, Ken-Ichi, Tomkinson, Alan E., Lasko, Dana D., Lindahl, Tomas

“…Human cDNA clones encoding the major DNA ligase activity in proliferating cells, DNA ligase I, were isolated by two independent methods. In one approach, a…”
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Role of deoxyribonucleic acid polymerase epsilon in spermatogenesis in mice by KAMEL, D, MACKEY, Z. B, SJÖBLOM, T, WALTER, C. A, MCCARREY, J. R, UITTO, L, PALOSAARI, H, LÄHDETIE, J, TOMKINSON, A. E, SYVÄOJA, J. E

“…Previous studies on DNA polymerase epsilon indicate that this enzyme is involved in replication of chromosomal DNA. In this study, we examined the expression…”
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Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation by Wang, Y.C., Burkhart, W.A., Mackey, Z.B., Moyer, M.B., Ramos, W, Husain, I, Chen, J, Besterman, J.M., Tomkinson, A.E.

“…Mammalian cells contain three biochemically distinct DNA ligases. In this report we describe the purification of DNA ligase II to homogeneity from bovine liver…”
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A Physical and Functional Interaction between Yeast Pol4 and Dnl4-Lif1 Links DNA Synthesis and Ligation in Nonhomologous End Joining by Tseng, Hui-Min, Tomkinson, Alan E

“…Genetic studies have implicated the Saccharomyces cerevisiae POL4 gene product in the repair of DNA double-strand breaks by nonhomologous end joining. Here we…”
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