Search Results - "Tomizawa, D."

Long-term outcome of 6-month maintenance chemotherapy for acute lymphoblastic leukemia in children by Kato, M, Ishimaru, S, Seki, M, Yoshida, K, Shiraishi, Y, Chiba, K, Kakiuchi, N, Sato, Y, Ueno, H, Tanaka, H, Inukai, T, Tomizawa, D, Hasegawa, D, Osumi, T, Arakawa, Y, Aoki, T, Okuya, M, Kaizu, K, Kato, K, Taneyama, Y, Goto, H, Taki, T, Takagi, M, Sanada, M, Koh, K, Takita, J, Miyano, S, Ogawa, S, Ohara, A, Tsuchida, M, Manabe, A

“…In the treatment of childhood acute lymphoblastic leukemia (ALL), excess shortening of maintenance therapy resulted in high relapse rate, as shown by our…”
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High expression of EVI1 and MEL1 is a compelling poor prognostic marker of pediatric AML by Jo, A, Mitani, S, Shiba, N, Hayashi, Y, Hara, Y, Takahashi, H, Tsukimoto, I, Tawa, A, Horibe, K, Tomizawa, D, Taga, T, Adachi, S, Yoshida, T, Ichikawa, H

“…EVI1 and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations are known in small subsets of leukemia. From gene expression…”
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Excess treatment reduction including anthracyclines results in higher incidence of relapse in core binding factor acute myeloid leukemia in children by Tomizawa, D, Tawa, A, Watanabe, T, Saito, A M, Kudo, K, Taga, T, Iwamoto, S, Shimada, A, Terui, K, Moritake, H, Kinoshita, A, Takahashi, H, Nakayama, H, Koh, K, Kigasawa, H, Kosaka, Y, Miyachi, H, Horibe, K, Nakahata, T, Adachi, S

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Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial by Tokumasu, M, Murata, C, Shimada, A, Ohki, K, Hayashi, Y, Saito, A M, Fujimoto, J, Horibe, K, Nagao, M, Itoh, H, Kamikubo, Y, Nakayama, H, Kinoshita, A, Tomizawa, D, Taga, T, Tawa, A, Tanaka, S, Heike, T, Adachi, S

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Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia by Koh, K, Tomizawa, D, Moriya Saito, A, Watanabe, T, Miyamura, T, Hirayama, M, Takahashi, Y, Ogawa, A, Kato, K, Sugita, K, Sato, T, Deguchi, T, Hayashi, Y, Takita, J, Takeshita, Y, Tsurusawa, M, Horibe, K, Mizutani, S, Ishii, E

“…Sixty-two infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia (MLL-r ALL) were treated with the MLL03 protocol of the Japanese Pediatric…”
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Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects : a final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group by TOMIZAWA, D, KOH, K, EGUCHI, M, HORIBE, K, NAKAHATA, T, MIZUTANI, S, ISHII, E, SATO, T, KINUKAWA, N, MORIMOTO, A, ISOYAMA, K, KOSAKA, Y, ODA, T, ODA, M, HAYASHI, Y

“…We evaluated the efficacy of a treatment strategy in which infants with acute lymphoblastic leukemia (ALL) were stratified by their MLL gene status and then…”
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Long-term results of Tokyo Children's Cancer Study Group trials for childhood acute lymphoblastic leukemia, 1984-1999 by Tsuchida, M, Ohara, A, Manabe, A, Kumagai, M, Shimada, H, Kikuchi, A, Mori, T, Saito, M, Akiyama, M, Fukushima, T, Koike, K, Shiobara, M, Ogawa, C, Kanazawa, T, Noguchi, Y, Oota, S, Okimoto, Y, Yabe, H, Kajiwara, M, Tomizawa, D, Ko, K, Sugita, K, Kaneko, T, Maeda, M, Inukai, T, Goto, H, Takahashi, H, Isoyama, K, Hayashi, Y, Hosoya, R, Hanada, R

“…We report the long-term results of Tokyo Children's Cancer Study Group's studies L84-11, L89-12, L92-13, and L95-14 for 1846 children with acute lymphoblastic…”
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Cord blood transplantation is associated with rapid B-cell neogenesis compared with BM transplantation by Nakatani, K, Imai, K, Shigeno, M, Sato, H, Tezuka, M, Okawa, T, Mitsuiki, N, Isoda, T, Tomizawa, D, Takagi, M, Nagasawa, M, Kajiwara, M, Yamamoto, M, Arai, A, Miura, O, Kamae, C, Nakagawa, N, Honma, K, Nonoyama, S, Mizutani, S, Morio, T

“…Hematopoietic cell transplantation (HCT) is used for treatment of hematopoietic diseases. Assessment of T- and B-cell reconstitution after HCT is crucial…”
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Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group by Matsuo, H, Kajihara, M, Tomizawa, D, Watanabe, T, Saito, A M, Fujimoto, J, Horibe, K, Kodama, K, Tokumasu, M, Itoh, H, Nakayama, H, Kinoshita, A, Taga, T, Tawa, A, Taki, T, Tanaka, S, Adachi, S

“…CCAAT/enhancer-binding protein alpha ( CEBPA ) mutations are a favorable prognostic factor in adult acute myeloid leukemia (AML) patients; however, few studies…”
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S255: EFFICACY AND SAFETY OF TISAGENLECLEUCEL IN PEDIATRIC AND YOUNG ADULT PATIENTS (PTS) WITH RELAPSED OR REFRACTORY (R/R) MATURE B‐CELL NON‐HODGKIN LYMPHOMA (NHL): THE PHASE II BIANCA STUDY by Minard‐Colin, V., Buechner, J., Locatelli, F., Gonzalez Martinez, B., Vormoor, B. J., Cooper, S., Krueger, J., Napolitano, S., Attarbaschi, A., Baruchel, A., Ghorashian, S., Hermiston, M. L., Hiramatsu, H., Ifversen, M., John, S., Khaw, S. L., O'Brien, T. A., Phillips, C. L., Diaz de Heredia, C., Tomizawa, D., Vettenranta, K., Wayne, A. S., Newsome, S., Awasthi, R., Redondo, S., Masood, A., Maude, S. L., Burkhardt, B.

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Hematopoietic stem cell transplantation for 30 patients with primary immunodeficiency diseases: 20 years experience of a single team by TSUJI, Y, IMAI, K, OHKAWA, H, YATA, J, SASAKI, N, KOGAWA, K, NAGASAWA, M, MORIO, T, NONOYAMA, S, MIZUTANI, S, KAJIWARA, M, AOKI, Y, ISODA, T, TOMIZAWA, D, IMAI, M, ITO, S, MAEDA, H, MINEGISHI, Y

“…We retrospectively analyzed our results of 30 patients with three distinctive primary immunodeficiency diseases (PIDs)--severe combined immunodeficiency (SCID,…”
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Invasive Subglottal Aspergillosis in a Patient with Severe Aplastic Anemia: A Case Report by Nagasawa, M., Itoh, S., Tomizawa, D., Kajiwara, M., Sugimoto, T., Kumagai, J.

“…A 19-year-old female with aplastic anemia who developed subglottal aspergillosis is reported. She presented with fever, cough and stridor. Inspiratory dyspnea…”
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High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core‐binding factor by Aoki, Takahiro, Shiba, Norio, Tsujimoto, Shinichi, Yamato, Genki, Hara, Yusuke, Kato, Shota, Yoshida, Kenichi, Ogawa, Seishi, Hayashi, Yasuhide, Iwamoto, Shotaro, Taki, Tomohiko, Shimada, Akira, Iijima‐Yamashita, Yuka, Horibe, Keizo, Tawa, Akio, Taga, Takashi, Adachi, Souichi, Tomizawa, Daisuke

“…CD25 is an aberrant marker expressed on the leukemic stem cell (LSC) surface and an immunotherapy target in acute myeloid leukemia (AML). However, the clinical…”
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MULTI-OMICS ANALYSIS DISSECTS M-MDSC LIKE IMMUNOMODULATORY CHARACTERISTICS OF LINEAGE SWITCHED AML WITH KMT2A-AFF1 by Mikami, T, Kato, I, Nishimura, A, Kamitori, T, Miyamura, T, Tomizawa, D, Imamura, T, Ogawa, S, Takagi, M, Takita, J

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Landscape of driver mutations and their clinical effects on Down syndrome–related myeloid neoplasms by Sato, Tomohiko, Yoshida, Kenichi, Toki, Tsutomu, Kanezaki, Rika, Terui, Kiminori, Saiki, Ryunosuke, Ojima, Masami, Ochi, Yotaro, Mizuno, Seiya, Yoshihara, Masaharu, Uechi, Tamayo, Kenmochi, Naoya, Tanaka, Shiro, Matsubayashi, Jun, Kisai, Kenta, Kudo, Ko, Yuzawa, Kentaro, Takahashi, Yuka, Tanaka, Tatsuhiko, Yamamoto, Yohei, Kobayashi, Akie, Kamio, Takuya, Sasaki, Shinya, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Muramatsu, Hideki, Hama, Asahito, Hasegawa, Daisuke, Sato, Atsushi, Koh, Katsuyoshi, Karakawa, Shuhei, Kobayashi, Masao, Hara, Junichi, Taneyama, Yuichi, Imai, Chihaya, Hasegawa, Daiichiro, Fujita, Naoto, Yoshitomi, Masahiro, Iwamoto, Shotaro, Yamato, Genki, Saida, Satoshi, Kiyokawa, Nobutaka, Deguchi, Takao, Ito, Masafumi, Matsuo, Hidemasa, Adachi, Souichi, Hayashi, Yasuhide, Taga, Takashi, Saito, Akiko M., Horibe, Keizo, Watanabe, Kenichiro, Tomizawa, Daisuke, Miyano, Satoru, Takahashi, Satoru, Ogawa, Seishi, Ito, Etsuro

“…•This study provides an overall picture of driver mutations in ML-DS, including novel and frequent IRX1 and ZBTB7A mutations, and RUNX1-PTD.•CDKN2A and TP53…”
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Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study by Yamato, Genki, Kawai, Tomoko, Shiba, Norio, Hara, Yusuke, Ohki, Kentaro, Kaburagi, Taeko, Ishikita, Etsuko, Kawasaki, Hirohide, Yoshida, Kenichi, Shiraishi, Yuichi, Miyano, Satoru, Kiyokawa, Nobutaka, Tomizawa, Daisuke, Shimada, Akira, Sotomatsu, Manabu, Takizawa, Takumi, Adachi, Souichi, Taga, Takashi, Horibe, Keizo, Ogawa, Seishi, Hata, Kenichiro, Hayashi, Yasuhide

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UBTF‐internal tandem duplication as a novel poor prognostic factor in pediatric acute myeloid leukemia by Kaburagi, Taeko, Shiba, Norio, Yamato, Genki, Yoshida, Kenichi, Tabuchi, Ken, Ohki, Kentaro, Ishikita, Etsuko, Hara, Yusuke, Shiraishi, Yuichi, Kawasaki, Hirohide, Sotomatsu, Manabu, Takizawa, Takumi, Taki, Tomohiko, Kiyokawa, Nobutaka, Tomizawa, Daisuke, Horibe, Keizo, Miyano, Satoru, Taga, Takashi, Adachi, Souichi, Ogawa, Seishi, Hayashi, Yasuhide

“…The prognosis of pediatric acute myeloid leukemia (AML) has improved via stratification therapy. However, relapse or death occurs in 30%–40% of cases. Novel…”
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Risk-stratified therapy for infant ALL

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TP53 and RB1 alterations characterize poor prognostic subgroups in pediatric acute myeloid leukemia by Hara, Yusuke, Shiba, Norio, Yoshida, Kenichi, Yamato, Genki, Kaburagi, Taeko, Shiraishi, Yuichi, Ohki, Kentaro, Shiozawa, Yusuke, Kawamura, Machiko, Kawasaki, Hirohide, Sotomatsu, Manabu, Takizawa, Takumi, Matsuo, Hidemasa, Shimada, Akira, Kiyokawa, Nobutaka, Tomizawa, Daisuke, Taga, Takashi, Ito, Etsuro, Horibe, Keizo, Miyano, Satoru, Adachi, Souichi, Taki, Tomohiko, Ogawa, Seishi, Hayashi, Yasuhide

“…Pediatric acute myeloid leukemia (AML) is a poor prognostic subtype of pediatric leukemia. However, the detailed characteristics of many genetic abnormalities…”
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RUNX1 mutations in pediatric acute myeloid leukemia are associated with distinct genetic features and an inferior prognosis by Yamato, Genki, Shiba, Norio, Yoshida, Kenichi, Hara, Yusuke, Shiraishi, Yuichi, Ohki, Kentaro, Okubo, Jun, Park, Myoung-ja, Sotomatsu, Manabu, Arakawa, Hirokazu, Kiyokawa, Nobutaka, Tomizawa, Daisuke, Adachi, Souichi, Taga, Takashi, Horibe, Keizo, Miyano, Satoru, Ogawa, Seishi, Hayashi, Yasuhide

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