Search Results - "Tomita, Urara"

A novel T cell-redirecting anti-GPRC5D × CD3 bispecific antibody with potent antitumor activity in multiple myeloma preclinical models by Tomita, Urara, Ishimoto, Yoko, Ri, Masaki, Kawase, Yumi, Hizukuri, Yoshiyuki, Maru, Chikako, Nanai, Kayoko, Nakamura, Ryuichi, Nakayama, Makiko, Oguchi-Oshima, Keiko, Sumi, Hiroyuki, Ohtsuka, Toshiaki, Iida, Shinsuke, Agatsuma, Toshinori

“…G-protein-coupled receptor class 5 member D (GPRC5D) is detected in malignant plasma cells in approximately 90% of patients diagnosed with multiple myeloma…”
Get full text

Poly(ethylene glycol)-Lipid-Conjugated Antibodies Enhance Dendritic Cell Phagocytosis of Apoptotic Cancer Cells by Tomita, Urara, Yamaguchi, Satoshi, Sugimoto, Yoichiro, Takamori, Satoshi, Nagamune, Teruyuki

“…A simple method for attaching immunoglobulin G (IgG) on the cell surface was successfully developed for enhancing phagocytosis of apoptotic tumor cells (ATCs)…”
Get full text

Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration by Matsui, T, Sekiguchi, M, Hashimoto, A, Tomita, U, Nishikawa, T, Wada, K

“…We compared the activity of free D-Ser on the potentiation of cloned NMDA receptors with that of Gly by using a Xenopus oocyte expression system. The…”
Get more information

Uptake of D-serine by synaptosomal P2 fraction isolated from rat brain by Yamamoto, Naoki, Tomita, Urara, Umino, Asami, Nishikawa, Toru

“…We have demonstrated that the crude synaptosome P2 fraction prepared from the rat brain is able to accumulate [3H]D‐serine in a saturable,…”
Get full text

Depletion of Cerebral D-Serine in Non-Ketotic Hyperglycinemia: Possible Involvement of Glycine Cleavage System in Control of Endogenous D-Serine by Iwama, Hisayuki, Takahashi, Katsunobu, Kure, Shigeo, Hayashi, Fumihiko, Narisawa, Kuniaki, Tada, Keiya, Mizoguchi, Masashi, Takashima, Sachio, Tomita, Urara, Nishikawa, Toru

“…Tissue concentrations of D-serine and other chiral and non-chiral amino acids were measured post-mortem in the cerebral cortex of the neonatal or infantile…”
Get full text

Protein cell-surface display through in situ enzymatic modification of proteins with a poly(Ethylene glycol)-lipid by Tomita, Urara, Yamaguchi, Satoshi, Maeda, Yasukazu, Chujo, Kazuki, Minamihata, Kosuke, Nagamune, Teruyuki

“…ABSTRACT Cell‐surface display of functional proteins is a powerful and useful tool for regulating and reinforcing cellular functions. Direct incorporation of…”
Get full text

Characterization of 5,7‐Dichlorokynurenate‐Insensitive d‐[3H]Serine Binding to Synaptosomal Fraction Isolated from Rat Brain Tissues by Matoba, Masaki, Tomita, Urara, Nishikawa, Toru

“…: To explore target sites for endogenous d‐serine that are different from the glycine site of the N‐methyl‐d‐aspartate (NMDA) type glutamate receptor, we have…”
Get full text

Quantitative analysis of cadherin-11 and β-catenin signalling during proliferation of rheumatoid arthritis-derived synovial fibroblast cells by Yoshioka, Ryosuke, Kita, Yasuhiro, Nagahira, Asako, Manno, Atsushi, Makita, Naoyuki, Tomita, Urara, Murakawa, Masao

“…Objectives Cadherin‐11 (CDH11) is an adhesion molecule that anchors β‐catenin and is involved with various functions of synovial fibroblast cells (SFCs) during…”
Get full text

Quantitative analysis of cadherin-11 and [beta]-catenin signalling during proliferation of rheumatoid arthritis-derived synovial fibroblast cells by Yoshioka, Ryosuke, Kita, Yasuhiro, Nagahira, Asako, Manno, Atsushi, Makita, Naoyuki, Tomita, Urara, Murakawa, Masao

“…Objectives Cadherin-11 (CDH11) is an adhesion molecule that anchors [beta]-catenin and is involved with various functions of synovial fibroblast cells (SFCs)…”
Get full text

Direct interactions of mastoparan and compound 48/80 with GTP-binding proteins by Tomita, U, Inanobe, A, Kobayashi, I, Takahashi, K, Ui, M, Katada, T

“…The effects of mastoparan and compound 48/80 on the activities of alpha beta gamma-trimeric GTP-binding proteins (G proteins) were studied with purified Go and…”
Get more information

Direct activation of purified Go-type GTP binding protein by tricyclic antidepressants by Yamamoto, H, Tomita, U, Mikuni, M, Kobayashi, I, Kagaya, A, Katada, T, Ui, M, Takahashi, K

“…A growing body of evidence suggests that tricyclic antidepressant agents (TCAs) interact with GTP binding proteins (G proteins). We have investigated if TCAs…”
Get more information

Muscarinic Agonists Release Adrenal Catecholamines by Mobilizing Intracellular Ca2 by NAKAZATO, Yoshikazu, YAMADA, Yutaka, TOMITA, Urara, OHGA, Akira

Get full text

Effects of bilateral olfactory bulbectomy on N-methyl-D-aspartate receptor function: Autoradiographic and behavioral studies in the rat by Robichaud, Malika, Beauchemin, Valérie, Lavoie, Normand, Dennis, Trevor, Debonnel, Guy

“…Rat bilateral olfactory bulbectomy (OBX) serves as a useful model in the study of depression and the mechanisms of action of antidepressant treatments…”
Get full text

A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils by Kanaho, Y, Takahashi, K, Tomita, U, Iiri, T, Katada, T, Ui, M, Nozawa, Y

“…In rabbit peritoneal neutrophils prelabeled with [3H] lyso platelet-activating factor, a protein kinase C inhibitor, staurosporine (> 1 microM), increased…”
Get full text

Synthesis and brain distribution of carbon-11 labeled analogs of antagonists for the NMDA receptor coupled PCP-binding site by Haradahira, Terushi, Sasaki, Sigeki, Maeda, Minoru, Kobayashi, Kaoru, Inoue, Osamu, Tomita, Urara, Nishikawa, Toru, Suzuki, Kazutoshi

“…Two phencyclidine (PCP) analogs, 3 and 4, and one thienylcyclohexyl‐piperidine (TCP) analog, (±)6, were labeled with positron emitter carbon‐11. These…”
Get full text

Characterization of four GO‐type proteins purified from bovine brain membranes by Inanobe, Atsushi, Shibasaki, Hisayuki, Takahashi, Katsunobu, Kobayashi, Ichiro, Tomita, Urara, Ui, Michio, Katada, Toshiaki

“…Recently we reported there were at least four types of GO or GO‐like proteins in bovine brain membranes based on their elution profiles from Mono Q columns and…”
Get full text

403 Metabolism of d-serine in mammalian brain by Takahashi, Katsunobu, Hayashi, Fumihiko, Matoba, Masaki, Iwama, Hisayuki, Tomita, Urara, Umino, Asami, Nishikawa, Toru

Get full text

Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction by Shinno, H, Mikuni, M, Saitoh, K, Tomita, U, Yamawaki, S, Takahashi, K

“…We found in cultured glioma (C6BU-1) cells that excitatory amino acids (EAAs) such as glutamate, N-methyl-D-aspartate (NMDA), aspartate, and metabotropic…”
Get more information

Serotonin-induced 5-HT1A receptor desensitization in C6BU-1 glioma cells transfected with 5-HT1A receptor gene by SAITOH, K, MIKUNI, M, IKEDA, M, YAMAZAKI, C, TOMITA, U, TAKAHASHI, K

“…In this study, it has been clearly demonstrated that a selective 5-hydroxytryptamine (5-HT)1A agonist, 8-OH-2-(di-n-propylamino)-tetraline (8-OH-DPAT, 1…”
Get full text

Direct activation of GTP-binding proteins by venom peptides that contain cationic clusters within their alpha-helical structures by Tomita, U, Takahashi, K, Ikenaka, K, Kondo, T, Fujimoto, I, Aimoto, S, Mikoshiba, K, Ui, M, Katada, T

“…Direct interactions of venom peptides that contained a cysteine-stabilized alpha-helical motif within their internal molecules with alpha beta gamma-trimeric…”
Get more information