Search Results - "Tomimoto, Daisuke"

Pharmacological Characterization of [trans-5′-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2′,3′-dihydrospiro(cyclohexane-1,1′-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA:Diacylglycerol Transferase (DGAT) 1 Inhibitor by Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Akiyama, Yoshiyuki, Ohta, Takeshi, Kakutani, Makoto, Ohkuma, Yoshiaki, Ogawa, Nobuya

“…Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the final step in triglyceride (TG) synthesis. This enzyme is considered to be a…”
Get full text

JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice by Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Kobayashi, Akio, Ohta, Takeshi, Kakutani, Makoto, Imanaka, Tsuneo, Ogawa, Nobuya

“…Type 2 diabetes mellitus (T2DM) arises primarily due to lifestyle factors and genetics. A number of lifestyle factors are known to be important in the…”
Get full text

A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice by Maekawa, Mariko, Tadaki, Hironobu, Tomimoto, Daisuke, Okuma, Chihiro, Sano, Ryuhei, Ishii, Yukihito, Katsuda, Yoshiaki, Yoshiuchi, Hiromi, Kakefuda, Reina, Ohta, Takeshi, Sasase, Tomohiko

“…Tumor necrosis factor-α (TNF-α) converting enzyme/a disintegrin and metalloproteinase domain-containing protein 17 (TACE/ADAM17) is a key sheddase that…”
Get full text

Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Leprfa (SDT Fatty) Rats by YAMAGUCHI, Takayuki, SASASE, Tomohiko, MERA, Yasuko, TOMIMOTO, Daisuke, TADAKI, Hironobu, KEMMOCHI, Yusuke, OHTA, Takeshi, SATO, Eimei, MATSUSHITA, Mutsuyoshi

“…Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia…”
Get full text

Diabetic peripheral neuropathy in Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats by Yamaguchi, Takayuki, Sasase, Tomohiko, Mera, Yasuko, Tomimoto, Daisuke, Tadaki, Hironobu, Kemmochi, Yusuke, Ohta, Takeshi, Sato, Eimei, Matsushita, Mutsuyoshi

“…Spontaneously Diabetic Torii (SDT) rat is a hereditary model of diabetes. Although the SDT rat shows severe diabetic complications, the onset of hyperglycemia…”
Get full text

A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice by Mariko Maekawaa, Hironobu Tadakia, Daisuke Tomimotoa, Chihiro Okumaa, Ryuhei Sanoa, Yukihito Ishiia, Yoshiaki Katsudaa, Hiromi Yoshiuchia, Reina Kakefudaa, Takeshi Ohtab, Tomohiko Sasasea

“…Tumor necrosis factor-α (TNF-α) converting enzyme/a disintegrin and metalloproteinase domain-containing protein 17 (TACE/ADAM17) is a key sheddase that…”
Get full text

JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Reduces Food Preference for Fat by Kakutani, Makoto, Kawai, Takashi, Tomimoto, Daisuke, Ishii, Yukihito, Hata, Takahiro, Mera, Yasuko, Ohta, Takeshi

“…Microsomal triglyceride transfer protein (MTP) is involved in the assembly and secretion of triglyceride-rich lipoproteins from enterocytes and hepatocytes…”
Get full text

JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner by Hata, Takahiro, Mera, Yasuko, Ishii, Yukihito, Tadaki, Hironobu, Tomimoto, Daisuke, Kuroki, Yukiharu, Kawai, Takashi, Ohta, Takeshi, Kakutani, Makoto

“…The microsomal triglyceride transfer protein (MTP) takes part in the mobilization and secretion of triglyceride-rich lipoproteins from enterocytes and…”
Get more information

A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury by Sato, Kota, Mochida, Seiya, Tomimoto, Daisuke, Konuma, Takahiro, Kiyota, Naoki, Tsuda, Satoru, Shiga, Yukihiro, Omodaka, Kazuko, Nakazawa, Toru

“…We aimed to assess the neuroprotective effect of a pyruvate dehydrogenase kinase (PDK) inhibitor, Nov3r after ischemia/reperfusion (IR) injury in rats. IR…”
Get full text

Pharmacological Characterization of [trans-5'-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA by Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Akiyama, Yoshiyuki, Ohta, Takeshi, Kakutani, Makoto, Ohkuma, Yoshiaki, Ogawa, Nobuya

“…Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the final step in triglyceride (TG) synthesis. This enzyme is considered to be a…”
Get full text

Discovery of 6‑Phenylpyrimido[4,5‑b][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents by Fox, Brian M, Sugimoto, Kazuyuki, Iio, Kiyosei, Yoshida, Atsuhito, Zhang, Jian (Ken), Li, Kexue, Hao, Xiaolin, Labelle, Marc, Smith, Marie-Louise, Rubenstein, Steven M, Ye, Guosen, McMinn, Dustin, Jackson, Simon, Choi, Rebekah, Shan, Bei, Ma, Ji, Miao, Shichang, Matsui, Takuya, Ogawa, Nobuya, Suzuki, Masahiro, Kobayashi, Akio, Ozeki, Hidekazu, Okuma, Chihiro, Ishii, Yukihito, Tomimoto, Daisuke, Furakawa, Noboru, Tanaka, Masahiro, Matsushita, Mutsuyoshi, Takahashi, Mitsuru, Inaba, Takashi, Sagawa, Shoichi, Kayser, Frank

“…The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is…”
Get full text

A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-A y Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice by Maekawa, Mariko, Tadaki, Hironobu, Tomimoto, Daisuke, Okuma, Chihiro, Sano, Ryuhei, Ishii, Yukihito, Katsuda, Yoshiaki, Yoshiuchi, Hiromi, Kakefuda, Reina, Ohta, Takeshi, Sasase, Tomohiko

“…Tumor necrosis factor-α (TNF-α) converting enzyme/a disintegrin and metalloproteinase domain-containing protein 17 (TACE/ADAM17) is a key sheddase that…”
Get full text