Search Results - "Tomimatsu, Kiminori"

Preparation of a 1-Unsubstituted 2,3-Dihydro-1-benzazepine Derivative by Nishiguchi, Atsuko, Ikemoto, Tomomi, Ito, Tatsuya, Miura, Shotaro, Tomimatsu, Kiminori

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Efficient syntheses of a novel 5-thia-1-azacycl[3.3.2]azine ring system and 3H-1,4-diazacycl[3.3.2]azine derivatives by Kawamoto, Tetsuji, Tomimatsu, Kiminori, Ikemoto, Tomomi, Abe, Hidenori, Hamamura, Kazumasa, Takatani, Muneo

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A Practical Method for Optical Resolution of Racemic Alcohols or Esters via Lipase-Catalyzed Transformation and Sulfation by Yamano, Toru, Kikumoto, Fumio, Yamamoto, Shozo, Miwa, Katsuhiko, Kawada, Mitsuru, Ito, Tatsuya, Ikemoto, Tomomi, Tomimatsu, Kiminori, Mizuno, Yukio

“…Optically active esters were conveniently obtained from the corresponding racemic alcohols or esters by lipase-catalyzed transformation, followed by sulfation…”
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Convenient synthesis of antisepsis agent TAK-242 by novel optical resolution through diastereomeric N-acylated sulfonamide derivative by Nishiguchi, Atsuko, Ikemoto, Tomomi, Tomimatsu, Kiminori

“…A convenient synthesis method of antisepsis agent TAK-242 (( R)- 1) through diastereomeric resolution was developed. By condensation of racemate rac- 1 with…”
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Studies on condensed-heterocyclic azolium cephalosporins. V. Synthesis and antibacterial activity of 3-(condensed-triazolo-pyridinium, -pyrimidinium, and -pyridazinium)-methyl cephalosporins by Yoshimura, Y, Tomimatsu, K, Nishimura, T, Miyake, A, Hashimoto, N

“…As a part of our studies on cephalosporins bearing condensed-heterocyclic azolium methyl groups at the 3 position in the cephalosporin nucleus, we describe…”
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Practical Synthesis of an Orally Active CCR5 Antagonist, 7-{4-[2-(Butoxy)- ethoxy]phenyl}-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)- 1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxamide by Ikemoto, Tomomi, Ito, Tatsuya, Nishiguchi, Atsuko, Miura, Syotaro, Tomimatsu, Kiminori

“…A practical method of synthesizing…”
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Facile synthesis of 7–10 membered rings by intramolecular condensation using dialkylcarbonate as solvent by Ikemoto, Tomomi, Ito, Tatsuya, Nishiguchi, Atsuko, Tomimatsu, Kiminori

“…[Display omitted] A convenient large-scalable synthesis of 1-benzazepines 19 as an important intermediate of CCR5 antagonist, oral HIV-1 therapy, was…”
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Efficient synthesis of CCR5 antagonist, 2,3-dihydro-1-benzothiepine derivatives by improved intramolecular Claisen type reaction using dialkylcarbonate by Ikemoto, Tomomi, Ito, Tatsuya, Nishiguchi, Atsuko, Tomimatsu, Kiminori

“…The efficient synthesis of 2,3-dihydro-1-benzothiepine derivatives 4 has been developed. The intramolecular Claisen type reaction of the new products, 4-(…”
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Asymmetric synthesis of ( R)-(+)-6-(1,4-dimethoxy-3-methyl-2-naphthyl)-6-(4-hydroxyphenyl)hexanoic acid as a key intermediate for a neurodegenerative disease agent by Ikemoto, Tomomi, Nagata, Toshiaki, Yamano, Mitsuhisa, Ito, Tatsuya, Mizuno, Yukio, Tomimatsu, Kiminori

“…[Display omitted] An asymmetric synthesis of ( R)-(+)-6-(1,4-dimethoxy-3-methyl-2-naphthyl)-6-(4-hydroxyphenyl)hexanoic acid 2 as a key intermediate for a…”
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Synthesis and Reactions of 10-Chloro-10, 9-(epoxyalkano)selenoxanthenes and 1-Chloro-1-phenyl-3H-2, 1-benzoxaselenoles by KATAOKA, Tadashi, SHIMIZU, Hiroshi, TOMIMATSU, Kiminori, TANAKA, Katsutoshi, HORI, Mikio, KIDO, Masaru

“…10-Chloro-10, 9-(epoxyalkano)selenoxanthenes (12, 14-17) were prepared by the reaction of 9-(hydroxyalkyl)-selenoxanthenes (4, 9-11) with N-chlorosuccinimide,…”
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Practical Synthesis of an Orally Active CCR5 Antagonist, 7-{4-[2-(Butoxy)- ethoxy]phenyl}- N -(4-{[methyl(tetrahydro-2 H -pyran-4-yl)amino]methyl}phenyl)- 1-propyl-2,3-dihydro-1 H -1-benzazepine-4-carboxamide by Ikemoto, Tomomi, Ito, Tatsuya, Nishiguchi, Atsuko, Miura, Syotaro, Tomimatsu, Kiminori

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A Practical Synthesis of the Chronic Renal Disease Agent, 4,5-Dihydro-3H-1,4,8b-triazaacenaphthylen-3-one Derivatives, Using Regioselective Chlorination of Ethyl 5-methylimidazo[1,2-a]pyridine-3-carboxylate with N-Chlorosuccinimide by Ikemoto, Tomomi, Kawamoto, Tetsuji, Tomimatsu, Kiminori, Takatani, Muneo, Wakimasu, Mitsuhiro

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Efficient Preparation of Medium Ring Oxygen Heterocycles by Nishiguchi, Atsuko, Ikemoto, Tomomi, Ito, Tatsuya, Miura, Shotaro, Tomimatsu, Kiminori

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Practical synthesis of ( R)-(+)-6-(1,4-dimethoxy-3-methyl-2-naphthyl)-6-(4-hydroxyphenyl)hexanoic acid: a key intermediate for a therapeutic drug for neurodegenerative diseases by Ito, Tatsuya, Ikemoto, Tomomi, Yamano, Toru, Mizuno, Yukio, Tomimatsu, Kiminori

“…A practical method for the preparation of ( R)-(+)-6-(1,4-dimethoxy-3-methyl-2-naphthyl)-6-(4-hydroxyphenyl)hexanoic acid ( R)- 2, a key intermediate for a…”
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Synthesis, Stereochemistry and Reactions of Selenoxanthen-10-io (alkoxalyl alkoxycarbonyl) methanides and Related Compounds by KATAOKA, TADASHI, TOMIMATSU, KIMINORI, SHIMIZU, HIROSHI, HORI, MIKIO

“…Selenoxanthene 10-oxides (5a-d) reacted with methyl propiolate, dimethyl and diethyl acetylenedicarboxylates to afford selenoxanthen-10-io [formyl (or…”
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Convenient efficient synthesis of TAK-779, a nonpeptide CCR5 antagonist: development of preparation of various ammonium salts using trialkylphosphite and N-halogenosuccinimide by Ikemoto, Tomomi, Nishiguchi, Atsuko, Mitsudera, Hiroyuki, Wakimasu, Mitsuhiro, Tomimatsu, Kiminori

“…A convenient and efficient synthesis of TAK-779 ( 1a), a nonpeptide CCR5 antagonist, has been achieved. The new methylation of tertiary amine ( 2) using…”
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A Practical Synthesis of the Chronic Renal Disease Agent, 4,5-Dihydro-3 H-1,4,8b-triazaacenaphthylen-3-one Derivatives, Using Regioselective Chlorination of Ethyl 5-methylimidazo[1,2- a]pyridine-3-carboxylate with N-Chlorosuccinimide by Ikemoto, Tomomi, Kawamoto, Tetsuji, Tomimatsu, Kiminori, Takatani, Muneo, Wakimasu, Mitsuhiro

“…A convenient synthesis of the chronic renal disease agent, trifluoro- N-[4-(3-oxo-3,5-dihydro-4 H-1,4,8b-triazaacenaphthylen-4-yl)butyl]methanesulfonamide (…”
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Large-scale synthesis of new cyclazines, 5-thia-1,8b-diazaacenaphthylene-3-carboxylic acid derivatives having the peripheral 12π-electron ring system by Ikemoto, Tomomi, Kawamoto, Tetsuji, Wada, Hiroki, Ishida, Toru, Ito, Tatsuya, Isogami, Yasushi, Miyano, Yoshiko, Mizuno, Yukio, Tomimatsu, Kiminori, Hamamura, Kazumasa, Takatani, Muneo, Wakimasu, Mitsuhiro

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Large-scale synthesis of new cyclazines, 5-thia-1,8 b-diazaacenaphthylene-3-carboxylic acid derivatives having the peripheral 12π-electron ring system by Ikemoto, Tomomi, Kawamoto, Tetsuji, Wada, Hiroki, Ishida, Toru, Ito, Tatsuya, Isogami, Yasushi, Miyano, Yoshiko, Mizuno, Yukio, Tomimatsu, Kiminori, Hamamura, Kazumasa, Takatani, Muneo, Wakimasu, Mitsuhiro

“…The 5-thia-1,8b-diazaacenaphthylenes ( 2 and its ester, 8 ) are new cyclazines, in which a paramagnetic ring is present in the peripheral 12π-electron ring…”
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Process Development of 4-[N-Methyl-N-(tetrahydropyran-4-yl)aminomethyl]aniline Dihydrochloride:  A Key Intermediate for TAK-779, a Small-Molecule Nonpeptide CCR5 Antagonist by Hashimoto, Hideo, Ikemoto, Tomomi, Itoh, Tatsuya, Maruyama, Hideaki, Hanaoka, Tadashi, Wakimasu, Mitsuhiro, Mitsudera, Hiroyuki, Tomimatsu, Kiminori

“…A new and efficient synthesis of 4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]aniline dihydrochloride, a key intermediate for the CCR5 antagonist TAK-779,…”
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