Search Results - "Tomilin, A. N."

Direct Reprogramming of Somatic Skin Cells from a Patient with Huntington’s Disease into Striatal Neurons to Create Models of Pathology by Kraskovskaya, N. A., Khotin, M. G., Tomilin, A. N., Mikhailova, N. A.

“…A new in vitro model of Huntington’s disease (HD) was developed via a direct reprogramming of dermal fibroblasts from HD patients into striatal neurons. A…”
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Transcriptional Coactivator BOB1 (OBF1, OCA-B) in Autoimmune Diseases by Tomilin, A. N., Yeremenko, N. G.

“…Autoimmune diseases, despite the significant work that has been carried out in biomedicine for several decades, continue to be largely incurable and poorly…”
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KH-Domain Poly(C)-Binding Proteins as Versatile Regulators of Multiple Biological Processes by Nazarov, I. B., Bakhmet, E. I., Tomilin, A. N.

“…Five known members of the family of KH-domain poly(C)-binding proteins (Pcbp1-4, hnRNP-K) have an unusually broad spectrum of cellular functions that include…”
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Pluripotency Dynamics during Embryogenesis and in Cell Culture by Gordeev, M. N., Bakhmet, E. I., Tomilin, A. N.

“…The early embryonic development of mice and humans is characterized by the presence of pluripotent cells, which give rise to all tissues of the developing…”
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Ubiquitin-Proteasome System in the Regulation of Cell Pluripotency and Differentiation by Podenkova, U. I., Zubarev, I. V., Tomilin, A. N., Tsimokha, A. S.

“…Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) demonstrate unique abilities for continuous self-renewal and differentiation into all…”
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Ubiquitin–Proteasome System in the Induction and Maintenance of Cellular Pluripotency by Zubarev, I. V., Podenkova, U. I., Tomilin, A. N., Tsimokha, A. S.

“…Pluripotent embryonic stem cells (ESCs) are derived from preimplantation blastocysts and can differentiate into all types of somatic cells. More recently…”
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Human Artificial Chromosomes and Their Transfer to Target Cells by Ponomartsev, S V, Sinenko, S A, Tomilin, A N

“…Human artificial chromosomes (HACs) have been developed as genetic vectors with the capacity to carry large transgenic constructs or entire gene loci. HACs…”
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Post-translational modifications of linker histone H1 variants in mammals by Starkova, T Yu, Polyanichko, A M, Artamonova, T O, Khodorkovskii, M A, Kostyleva, E I, Chikhirzhina, E V, Tomilin, A N

“…The covalent modifications of the linker histone H1 and the core histones are thought to play an important role in the control of chromatin functioning…”
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20S Proteasome Intratumoral Delivery Effect on Lifespan of Melanoma-bearing Mice by Diakonov, E. E., Ponomartsev, S. V., Zyubko, T. I., Tomilin, A. N., Tsimokha, A. S.

“…The ubiquitin-proteasome system is involved in the regulation of most major intracellular processes, and disruptions in the functioning of this system lead to…”
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The Profile of Post-translational Modifications of Histone H1 in Chromatin of Mouse Embryonic Stem Cells by Starkova, T Yu, Artamonova, T O, Ermakova, V V, Chikhirzhina, E V, Khodorkovskii, M A, Tomilin, A N

“…Linker histone H1 is one of the main chromatin proteins which plays an important role in organizing eukaryotic DNA into a compact structure. There is data…”
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Establishment of the HeLa Cell Line with Stable Expression of CD63 Exosome Marker Fused with Fluorescent Protein TagRFP and HTBH Tag by Kulichkova, V. A., Selenina, A. V., Tomilin, A. N., Tsimokha, A. S.

“…Exosomes are small microvesicles released into the cellular environment by different types of cells. These vesicles have been found in the blood serum and in…”
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Expression and Purification of C-Terminal Region of PI31 Protein to Inhibit 20S Proteasome Activity by Diakonov, E. E., Malkina, E. A., Kulichkova, V. A., Tomilin, A. N., Tsimokha, A. S.

“…PI31 protein, a proteasome inhibitor, is 271 amino acid residues long and contains N-terminal globular and C-terminal proline-rich domains…”
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Proteasomes in Protein Homeostasis of Pluripotent Stem Cells by Selenina, A V, Tsimokha, A S, Tomilin, A N

“…Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are subjects of high interest not only in basic research, but also in various applied…”
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Transcription regulation of Oct4 (Pou5F1) gene by its distal enhancer by Nazarov, I. B., Krasnoborova, V. A., Mitenberg, A. G., Chikhirzhina, E. V., Davidov-Sinitzin, A. P., Liskovykh, M. A., Tomilin, A. N.

“…The study of Oct4 gene regulation in murine embryonic stem cells revealed that distal enhancer (DE) was its key element. DE includes two functional elements,…”
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Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin by Belokopytova, I A, Kostyleva, E I, Tomilin, A N, Vorob'ev, V I

“…Basic chromosomal proteins were extracted from the sperm of fertile and infertile human males. The relative proportions of protamine 1, 2, and 3 were…”
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Genome-Wide Mutagenesis in Mice: In Search for Genes Regulating Immune Responses and Inflammation by Astrakhantseva, I. V., Tomilin, A. N., Tarabykin, V. S., Nedospasov, S. A.

“…Genome-wide mutagenesis induced by N -ethyl- N -nitrosourea (ENU) results in efficient introduction of mutations into the genome of mammalian spermatogonial…”
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E-cadherin as a novel surface marker of spermatogonial stem cells by Tolkunova, E. N., Malashicheva, A. B., Chikhirzhina, E. V., Kostyleva, E. I., Zeng, W., Luo, J., Dobrinski, I., Hierholzer, A., Kemler, R., Tomilin, A. N.

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On diagnosing the level of students’ knowledge in special (conventional) disciplines by Tomilin, A.N., Tomilina, S.N., Panikina, S.I.

“…One of the most important tasks of professional training of cadets at maritime universities is to prepare them for competent actions in any accident and…”
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The 2012 Nobel Prize in Physiology or Medicine by Tomilin, A. N.

“…The 2012 Nobel Prize in physiology or medicine has been awarded to John Bertrand Gurdon and Shinya Yamanaka for the discovery that mature cells can be…”
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Establishing a Cell Model for Studying the Interaction of the Pou5f1 (Oct4) Promoter with the Genetic Environment by Kuzmin, A. A., Ermakova, V. V., Potapenko, E. V., Ostroverkhova, M. G., Guriev, N. A., Tomilin, A. N.

“…Pou5f1 ( Oct4 ), a key gatekeeper of cellular pluripotency, has little been studied with regard to roles of its regulatory cis -elements in transcriptional…”
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