Search Results - "Tomhave, E. D."

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade by IACCARINO, G, TOMHAVE, E. D, LEFKOWITZ, R. J, KOCH, W. J

“…Impaired myocardial beta-adrenergic receptor (betaAR) signaling, including desensitization and functional uncoupling, is a characteristic of congestive heart…”
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Human calcium‐calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine‐177 by calcium‐calmodulin dependent protein kinase I kinase by Haribabu, B., Hook, S. S., Selbert, M. A., Goldstein, E. G., Tomhave, E. D., Edelman, A. M., Snyderman, R., Means, A. R.

“…Human Ca(2+)‐calmodulin (CaM) dependent protein kinase I (CaMKI) encodes a 370 amino acid protein with a calculated M(r) of 41,337. The 1.5 kb CaMKI mRNA is…”
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Differences in phosphorylation of formylpeptide and C5a chemoattractant receptors correlate with differences in desensitization by HYDAR ALI, RICHARDSON, R. M, TOMHAVE, E. D, DIDSBURY, J. R, SNYDERMAN, R

“…To define the regulation of chemoattractant receptors, epitope-tagged human formyl peptide and C5a receptor cDNAs (ET-FR and ET-C5aR) were stably expressed in…”
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Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation by Tomhave, ED, Richardson, RM, Didsbury, JR, Menard, L, Snyderman, R, Ali, H

“…The formylpeptide (fMLP) and C5a chemoattractants were previously shown to cross-desensitize each other's ability to mobilize Ca2+ in leukocytes but not to…”
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Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation by Ali, H, Richardson, R M, Tomhave, E D, DuBose, R A, Haribabu, B, Snyderman, R

“…Platelet activating factor (PAF) interacts with cell surface receptors to mediate inflammatory responses. To determine the mechanisms of PAF receptor…”
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Cross-desensitization of chemoattractant receptors occurs at multiple levels. Evidence for a role for inhibition of phospholipase C activity by Richardson, R M, Ali, H, Tomhave, E D, Haribabu, B, Snyderman, R

“…To define the molecular mechanisms of cross-regulation among chemoattractant receptors, we stably coexpressed, in a rat basophilic leukemia (RBL-2H3) cell…”
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Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs by Iaccarino, G, Rockman, H A, Shotwell, K F, Tomhave, E D, Koch, W J

“…Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase 3 (GRK3) to explore the in vivo role of this GRK…”
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Regulation of Human Interleukin-8 Receptor A: Identification of a Phosphorylation Site Involved in Modulating Receptor Functions by Richardson, Ricardo M, DuBose, Robert A, Ali, Hydar, Tomhave, Eric D, Haribabu, Bodduluri, Snyderman, Ralph

“…The human type A interleukin-8 receptor (IL-8RA) was modified to express an amino-terminal epitope tag and stably overexpressed in a rat basophilic leukemia…”
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Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases by Xiao, R P, Tomhave, E D, Wang, D J, Ji, X, Boluyt, M O, Cheng, H, Lakatta, E G, Koch, W J

“…While an age-associated diminution in myocardial contractile response to beta-adrenergic receptor (beta-AR) stimulation has been widely demonstrated to occur…”
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Thrombin Primes Responsiveness of Selective Chemoattractant Receptors at a Site Distal to G Protein Activation (∗) by Ali, Hydar, Tomhave, Eric D., Richardson, Ricardo M., Haribabu, Bodduluri, Snyderman, Ralph

“…To define the molecular basis of human chemoattractant receptor regulation, rat basophilic leukemia RBL-2H3 cells, which are thrombin-responsive, were…”
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Thrombin primes responsiveness of selective chemoattractant receptors at a site distal to G protein activation by Ali, H, Tomhave, ED, Richardson, R M, Haribabu, B, Snyderman, R

“…To define the molecular basis of human chemoattractant receptor regulation, rat basophilic leukemia RBL-2H3 cells, which are thrombin-responsive, were…”
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