Search Results - "Tomescu, Costin"

Identification of the predominant human NK cell effector subset mediating ADCC against HIV‐infected targets coated with BNAbs or plasma from PLWH by Tomescu, Costin, Kroll, Kyle, Colon, Krystal, Papasavvas, Emmanouil, Frank, Ian, Tebas, Pablo, Mounzer, Karam, Reeves, Roger Keith, Montaner, Luis J.

“…The potential of immunotherapy strategies utilizing broadly neutralizing antibodies (BNAbs), such as 3BNC117 and 10‐1074, to limit viral replication while also…”
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Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells by Adeniji, Opeyemi S, Kuri-Cervantes, Leticia, Yu, Chenfei, Xu, Ziyang, Ho, Michelle, Chew, Glen M, Shikuma, Cecilia, Tomescu, Costin, George, Ashley F, Roan, Nadia R, Ndhlovu, Lishomwa C, Liu, Qin, Muthumani, Kar, Weiner, David B, Betts, Michael R, Xiao, Han, Abdel-Mohsen, Mohamed

“…Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK) cells. Siglec-9 restrains NK cytotoxicity by binding to…”
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A correlate of HIV-1 control consisting of both innate and adaptive immune parameters best predicts viral load by multivariable analysis in HIV-1 infected viremic controllers and chronically-infected non-controllers by Tomescu, Costin, Liu, Qin, Ross, Brian N, Yin, Xiangfan, Lynn, Kenneth, Mounzer, Karam C, Kostman, Jay R, Montaner, Luis J

“…HIV-1 infected viremic controllers maintain durable viral suppression below 2000 copies viral RNA/ml without anti-retroviral therapy (ART), and the…”
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Inability of Plasmacytoid Dendritic Cells To Directly Lyse HIV-Infected Autologous CD4+ T Cells despite Induction of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand by CHEHIMI, Jihed, PAPASAVVAS, Emmanouil, PISTILLI, Maxwell, MOUNZER, Karam, KOSTMAN, Jay, MONTANER, Luis J, TOMESCU, Costin, GEKONGE, Bethsebah, ABDULHAQQ, Shaheed, RAYMOND, Andrea, HANCOCK, Aidan, VINEKAR, Kavita, CARTY, Craig, REYNOLDS, Griffin

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Retention of viability, cytotoxicity, and response to IL-2, IL-15, or IFN-α by human NK cells after CD107a degranulation by Tomescu, Costin, Chehimi, Jihed, Maino, Vernon C., Montaner, Luis J.

“…NK cells represent a critical component of the host innate immune response to viral infection and tumor transformation. Nevertheless, the fate of recently…”
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Surface Downregulation of Major Histocompatibility Complex Class I, PE-CAM, and ICAM-1 following De Novo Infection of Endothelial Cells with Kaposi's Sarcoma-Associated Herpesvirus by Tomescu, Costin, Law, Wai K, Kedes, Dean H

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Intracellular Kaposi's Sarcoma-Associated Herpesvirus Load Determines Early Loss of Immune Synapse Components by ADANG, Laura A, TOMESCU, Costin, LAW, Wai K, KEDES, Dean H

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Lysis of HIV-1-infected autologous CD4+ primary T cells by interferon-alpha-activated NK cells requires NKp46 and NKG2D by Tomescu, Costin, Mavilio, Domenico, Montaner, Luis J

“…Autologous HIV-1-infected CD4 primary T cells (aHIVCD4) have been shown to be largely resistant to natural killer (NK)-cell-mediated lysis because of viral…”
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IFN-α augments natural killer-mediated antibody-dependent cellular cytotoxicity of HIV-1-infected autologous CD4+ T cells regardless of major histocompatibility complex class 1 downregulation by Tomescu, Costin, Tebas, Pablo, Montaner, Luis J

“…DESIGN:We have previously shown that IFN-α stimulation augments direct natural killer (NK) cell lysis of autologous CD4 primary T cells infected with certain…”
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IFN- augments natural killer-mediated antibody-dependent cellular cytotoxicity of HIV-1-infected autologous CD4+ T cells regardless of major histocompatibility complex class 1 downregulation by Tomescu, Costin, Tebas, Pablo, Montaner, Luis J

“…Design: We have previously shown that IFN- alpha stimulation augments direct natural killer (NK) cell lysis of autologous CD4 super(+) primary T cells infected…”
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Persons who inject drugs (PWID) retain functional NK cells, dendritic cell stimulation, and adaptive immune recall responses despite prolonged opioid use by Tomescu, Costin, Colon, Krystal, Smith, Peter, Taylor, Mack, Azzoni, Livio, Metzger, David S., Montaner, Luis J.

“…Previous literature suggests that acute opioid use results in the functional impairment of the immune response, thereby decreasing resistance to viral…”
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The role of CD32 during HIV-1 infection by Bertagnolli, Lynn N., White, Jennifer A., Simonetti, Francesco R., Beg, Subul A., Lai, Jun, Tomescu, Costin, Murray, Alexandra J., Antar, Annukka A. R., Zhang, Hao, Margolick, Joseph B., Hoh, Rebecca, Deeks, Stephen G., Tebas, Pablo, Montaner, Luis J., Siliciano, Robert F., Laird, Gregory M., Siliciano, Janet D.

“…Persistence of latent HIV-1 in long-lived resting memory CD4+ T cells is a major barrier to curing HIV-1 infection, and thus a biomarker for latently infected…”
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S100A14 Is Increased in Activated NK Cells and Plasma of HIV-Exposed Seronegative People Who Inject Drugs and Promotes Monocyte–NK Crosstalk by Colón, Krystal, Speicher, David W, Smith, Peter, Taylor, Mack, Metzger, David S, Montaner, Luis J, Tomescu, Costin

“…BACKGROUND:HIV-exposed seronegative people who inject drugs (HESN-PWID) have been shown to have increased natural killer (NK) cell and myeloid activation when…”
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BCL6 Inhibitor-Mediated Downregulation of Phosphorylated SAMHD1 and T Cell Activation Are Associated with Decreased HIV Infection and Reactivation by Cai, Yanhui, Abdel-Mohsen, Mohamed, Tomescu, Costin, Xue, Fengtian, Wu, Guoxin, Howell, Bonnie J, Ai, Yong, Sun, Jie, Azzoni, Livio, Le Coz, Carole, Romberg, Neil, Montaner, Luis J

“…Clearance of HIV-infected germinal center (GC) CD4 follicular helper T cells (Tfh) after combination antiretroviral therapy (ART) is essential to an HIV cure…”
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Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells by Opeyemi S. Adeniji, Leticia Kuri-Cervantes, Chenfei Yu, Ziyang Xu, Michelle Ho, Glen M. Chew, Cecilia Shikuma, Costin Tomescu, Ashley F. George, Nadia R. Roan, Lishomwa C. Ndhlovu, Qin Liu, Kar Muthumani, David B. Weiner, Michael R. Betts, Han Xiao, Mohamed Abdel-Mohsen

“…Siglec-9 is an MHC-independent inhibitory receptor expressed on a subset of natural killer (NK) cells. Siglec-9 restrains NK cytotoxicity by binding to…”
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Impact of protective killer inhibitory receptor/human leukocyte antigen genotypes on natural killer cell and T-cell function in HIV-1-infected controllers by TOMESCU, Costin, DUH, Fuh-Mei, HOH, Rebecca, VIVIANI, Anne, HARVILL, Kara, MARTIN, Maureen P, CARRINGTON, Mary, DEEKS, Steven G, MONTANER, Luis J

“…Both protective T-cell genotypes and natural killer (NK) cell genotypes have been associated with delayed progression to AIDS and shown to be co-inherited in…”
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NK Cell Lysis of HIV-1-Infected Autologous CD4 Primary T Cells: Requirement for IFN-Mediated NK Activation by Plasmacytoid Dendritic Cells by Tomescu, Costin, Chehimi, Jihed, Maino, Vernon C, Montaner, Luis J

“…In vivo, several mechanisms have been postulated to protect HIV-1-infected cells from NK surveillance. In vitro, previous research indicates HIV-1-infected…”
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Innate Activation of MDC and NK Cells in High-Risk HIV-1–Exposed Seronegative IV-Drug Users Who Share Needles When Compared With Low-Risk Nonsharing IV-Drug User Controls by Tomescu, Costin, Seaton, Kelly E, Smith, Peter, Taylor, Mack, Tomaras, Georgia D, Metzger, David S, Montaner, Luis J

“…BACKGROUND:Previous studies have described increased innate immune activation in HIV-1–exposed seronegative intravenous drug users (HESN-IDU), but have not…”
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The role of CD32 during HIV-1 infection by Bertagnolli, Lynn N, White, Jennifer A, Simonetti, Francesco R, Beg, Subul A, Lai, Jun, Tomescu, Costin, Murray, Alexandra J, Antar, Annukka A R, Zhang, Hao, Margolick, Joseph B, Hoh, Rebecca, Deeks, Stephen G, Tebas, Pablo, Montaner, Luis J, Siliciano, Robert F, Laird, Gregory M, Siliciano, Janet D

“…[...]CD32 does not seem to be a specific biomarker of latently infected CD4+ T cells. [...]cells would be removed during the negative selection used to isolate…”
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Innate Activation of MDC and NK Cells in High-risk HIV-1 Exposed, Sero-Negative (HESN) IV-Drug Users that Share Needles When Compared to Low-risk Non-sharing IV-Drug User Controls by Tomescu, Costin, Seaton, Kelly E., Smith, Peter, Taylor, Mack, Tomaras, Georgia D., Metzger, David S., Montaner, Luis J.

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