Search Results - "Tomczyk, Marta"
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Vitamin B12 Metabolism: A Network of Multi-Protein Mediated Processes
Published in International journal of molecular sciences (01-08-2024)“…The water-soluble vitamin, vitamin B12, also known as cobalamin, plays a crucial role in cellular metabolism, particularly in DNA synthesis, methylation, and…”
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2
Purine Nucleotides Metabolism and Signaling in Huntington’s Disease: Search for a Target for Novel Therapies
Published in International journal of molecular sciences (18-06-2021)“…Huntington’s disease (HD) is a multi-system disorder that is caused by expanded CAG repeats within the exon-1 of the huntingtin (HTT) gene that translate to…”
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4-Pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR)-A Novel Oncometabolite Modulating Cancer-Endothelial Interactions in Breast Cancer Metastasis
Published in International journal of molecular sciences (21-05-2022)“…The accumulation of specific metabolic intermediates is known to promote cancer progression. We analyzed the role of…”
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4
Inorganic Polyphosphate-Regulator of Cellular Metabolism in Homeostasis and Disease
Published in Biomedicines (15-04-2022)“…Inorganic polyphosphate (polyP), a simple anionic polymer consisting of even hundreds of orthophosphate units, is a universal molecule present in both simple…”
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5
Enhanced Muscle Strength in Dyslipidemic Mice and Its Relation to Increased Capacity for Fatty Acid Oxidation
Published in International journal of molecular sciences (12-11-2021)“…Dyslipidemia is commonly linked to skeletal muscle dysfunction, accumulation of intramyocellular lipids, and insulin resistance. However, our previous research…”
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Metabolomic Footprint of Disrupted Energetics and Amino Acid Metabolism in Neurodegenerative Diseases: Perspectives for Early Diagnosis and Monitoring of Therapy
Published in Metabolites (01-03-2023)“…The prevalence of neurodegenerative diseases (NDs) is increasing due to the aging population and improved longevity. They are characterized by a range of…”
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High Throughput Procedure for Comparative Analysis of In Vivo Cardiac Glucose or Amino Acids Use in Cardiovascular Pathologies and Pharmacological Treatments
Published in Metabolites (30-07-2021)“…The heart is characterized by the prominent flexibility of its energy metabolism and is able to use diverse carbon substrates, including carbohydrates and…”
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Rosiglitazone Ameliorates Cardiac and Skeletal Muscle Dysfunction by Correction of Energetics in Huntington’s Disease
Published in Cells (Basel, Switzerland) (27-08-2022)“…Huntington’s disease (HD) is a rare neurodegenerative disease that is accompanied by skeletal muscle atrophy and cardiomyopathy. Tissues affected by HD…”
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Differences in Extracellular NAD + and NMN Metabolism on the Surface of Vascular Endothelial Cells
Published in Biology (Basel, Switzerland) (27-04-2022)“…The disruption of the metabolism of extracellular NAD and NMN may affect related signaling cascades and pathologies, such as cardiovascular or respiratory…”
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10
Seasonality and objective physical activity and sedentary behaviour among older adults from four european countries
Published in Healthcare (Basel) (25-08-2023)“…© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative…”
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Chain-length dependent effects of inorganic polyphosphate on endothelial function and nucleotide pool
Published in Nucleosides, nucleotides & nucleic acids (2024)“…Endothelial cells (ECs) are the first line that comes into contact with blood pathogens, pathogen-derived molecules, and factors that stimulate coagulation and…”
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12
Vitamin B[sub.12] Metabolism: A Network of Multi-Protein Mediated Processes
Published in International journal of molecular sciences (01-08-2024)“…The water-soluble vitamin, vitamin B[sub.12], also known as cobalamin, plays a crucial role in cellular metabolism, particularly in DNA synthesis, methylation,…”
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13
Huntingtin protein maintains balanced energetics in mouse cardiomyocytes
Published in Nucleosides, nucleotides & nucleic acids (2022)“…Huntingtin (HTT) is a multifunctional protein crucial for proper embryogenesis and nervous system development. Mutation of a single allele in gene coded this…”
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14
Vitamin B 12 Metabolism: A Network of Multi-Protein Mediated Processes
Published in International journal of molecular sciences (23-07-2024)“…The water-soluble vitamin, vitamin B , also known as cobalamin, plays a crucial role in cellular metabolism, particularly in DNA synthesis, methylation, and…”
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15
Enhanced cardiac hypoxic injury in atherogenic dyslipidaemia results from alterations in the energy metabolism pattern
Published in Metabolism, clinical and experimental (01-01-2021)“…Dyslipidaemia is a major risk factor for myocardial infarction that is known to correlate with atherosclerosis in the coronary arteries. We sought to clarify…”
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16
Hair dysmorphology in the R6/1 and R6/2 mouse models of Huntington’s disease
Published in Gene (10-01-2021)“…•Pelage is changed in the R61/ and R6/2 mouse models of Huntington’s disease (HD)•Hair dysmorphology, assessed by scanning electron microscopy, is evident in…”
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The metabolism of ecto-5'-nucleotidase (CD73) inhibitor-[alpha],[beta]-methylene adenosine diphosphate in BALB/c mice
Published in Nucleosides, nucleotides & nucleic acids (01-01-2018)“…CD73 inhibitors are considered to be used in the therapies of melanomas, gliomas or breast cancer. However, little is known about their pharmacology and…”
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The metabolism of ecto-5'-nucleotidase (CD73) inhibitor-α,β-methylene adenosine diphosphate in BALB/c mice
Published in Nucleosides, nucleotides & nucleic acids (02-12-2018)“…CD73 inhibitors are considered to be used in the therapies of melanomas, gliomas or breast cancer. However, little is known about their pharmacology and…”
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19
Chain-length dependent effects of inorganic polyphosphate on endothelial function and nucleotide pool
Published in Nucleosides, Nucleotides & Nucleic Acids: Proceedings of the 20th International Symposium on Purine and Pyrimidine Metabolism in Man (02-08-2024)“…Endothelial cells (ECs) are the first line that comes into contact with blood pathogens, pathogen-derived molecules, and factors that stimulate coagulation and…”
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