Search Results - "Tomchuck, Suzanne L."

A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype by Waterman, Ruth S, Tomchuck, Suzanne L, Henkle, Sarah L, Betancourt, Aline M

“…Our laboratory and others reported that the stimulation of specific Toll-like receptors (TLRs) affects the immune modulating responses of human multipotent…”
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pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells by Coffelt, Seth B, Marini, Frank C, Watson, Keri, Zwezdaryk, Kevin J, Dembinski, Jennifer L, LaMarca, Heather L, Tomchuck, Suzanne L, zu Bentrup, Kerstin Honer, Danka, Elizabeth S, Henkle, Sarah L, Scandurro, Aline B

“…Bone marrow-derived mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs) have been shown to engraft into the stroma of several tumor types,…”
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Piezo1 facilitates optimal T cell activation during tumor challenge by abiff, muta, Alshebremi, Mohammad, Bonner, Melissa, Myers, Jay T., Kim, Byung-Gyu, Tomchuck, Suzanne L., Santin, Alicia, Kingsley, Daniel, Choi, Sung Hee, Huang, Alex Y.

“…Functional effector T cells in the tumor microenvironment (TME) are critical for successful anti-tumor responses. T cell anti-tumor function is dependent on…”
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Treatment response and outcome of children with T-cell acute lymphoblastic leukemia expressing the gamma-delta T-cell receptor by Pui, Ching-Hon, Pei, Deqing, Cheng, Cheng, Tomchuck, Suzanne L., Evans, Scarlett N., Inaba, Hiroto, Jeha, Sima, Raimondi, Susana C., Choi, John K., Thomas, Paul G., Dallas, Mari Hashitate

“…T-cell malignancies expressing the γδ T-cell receptor (TCR) are often associated with poor prognosis. Here, we determined the clinical outcome of pediatric…”
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Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation by Alshebremi, Mohammad, Tomchuck, Suzanne L, Myers, Jay T, Kingsley, Daniel T, Eid, Saada, Abiff, Muta, Bonner, Melissa, Saab, Shahrazad T, Choi, Sung Hee, Huang, Alex Yee-Chen

“…Despite its potential utility in delivering direct tumor killing and in situ whole-cell tumor vaccination, tumor cryoablation produces highly variable and…”
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Leucine Leucine-37 Uses Formyl Peptide Receptor–Like 1 to Activate Signal Transduction Pathways, Stimulate Oncogenic Gene Expression, and Enhance the Invasiveness of Ovarian Cancer Cells by Coffelt, Seth B, Tomchuck, Suzanne L, Zwezdaryk, Kevin J, Danka, Elizabeth S, Scandurro, Aline B

“…Emerging evidence suggests that the antimicrobial peptide, leucine leucine-37 (LL-37), could play a role in the progression of solid tumors. LL-37 is expressed…”
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Ovarian cancers overexpress the antimicrobial protein hCAP‐18 and its derivative LL‐37 increases ovarian cancer cell proliferation and invasion by Coffelt, Seth B., Waterman, Ruth S., Florez, Luisa, Bentrup, Kerstin Höner zu, Zwezdaryk, Kevin J., Tomchuck, Suzanne L., LaMarca, Heather L., Danka, Elizabeth S., Morris, Cindy A., Scandurro, Aline B.

“…The role of the pro‐inflammatory peptide, LL‐37, and its pro‐form, human cationic antimicrobial protein 18 (hCAP‐18), in cancer development and progression is…”
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Toll-like receptor 3 and suppressor of cytokine signaling proteins regulate CXCR4 and CXCR7 expression in bone marrow-derived human multipotent stromal cells by Tomchuck, Suzanne L, Henkle, Sarah L, Coffelt, Seth B, Betancourt, Aline M

“…The use of bone marrow-derived human multipotent stromal cells (hMSC) in cell-based therapies has dramatically increased in recent years, as researchers have…”
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Toll‐Like Receptors on Human Mesenchymal Stem Cells Drive Their Migration and Immunomodulating Responses by Tomchuck, Suzanne L., Zwezdaryk, Kevin J., Coffelt, Seth B., Waterman, Ruth S., Danka, Elizabeth S., Scandurro, Aline B.

“…Adult human bone marrow‐derived mesenchymal stem cells (hMSCs) are under study as therapeutic delivery agents that assist in the repair of damaged tissues. To…”
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Mesenchymal stem cells as a novel vaccine platform by Tomchuck, Suzanne L, Norton, Elizabeth B, Garry, Robert F, Bunnell, Bruce A, Morris, Cindy A, Freytag, Lucy C, Clements, John D

“…Vaccines are the most efficient and cost-effective means of preventing infectious disease. However, traditional vaccine approaches have thus far failed to…”
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Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation by Chen, Yi Fan, Ghazala, Maryam, Friedrich, Ryan M., Cordova, Brittany A., Petroze, Frederick N., Srinivasan, Ramya, Allan, Kevin C., Yan, David F., Sax, Joel L., Carr, Kelley, Tomchuck, Suzanne L., Fedorov, Yuriy, Huang, Alex Y., Desai, Amar B., Adams, Drew J.

“…Exportin-1 (XPO1/CRM1) plays a central role in the nuclear-to-cytoplasmic transport of hundreds of proteins and contributes to other cellular processes, such…”
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Preconditioning hippocampal slices with hypothermia promotes rapid tolerance to hypoxic depolarization and swelling: Mediation by erythropoietin by Kreisman, Norman R., Wooliscroft, Lindsey B., Campbell, Carolyn F., Dotiwala, Ary K., Cox, Michael L., Denson, Aaron C., Betancourt, Aline M., Tomchuck, Suzanne L.

“…•Hypothermic preconditioning induced tolerance to hypoxic depolarization and swelling.•Exogenous erythropoietin (EPO) mitigated hypoxic depolarization and…”
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Enhanced Cytotoxic Function of Natural Killer and CD3+ CD56+ Cells in Cord Blood after Culture by Tomchuck, Suzanne L, Leung, Wing H, Dallas, Mari H

“…Abstract Rate of immune reconstitution directly correlates with the number of hematopoietic stem cells infused and is particularly delayed in patients…”
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Isolation, Expansion & Function of Cord Blood Natural Killer Cells by Tomchuck, Suzanne L, Leung, Wing, Dallas, Mari Hashitate

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Zoledronic Acid-Mediated Ex Vivo Expansion and Function of Human Umbilical Cord Blood Gamma Delta T Cells Is Distinct from Human Peripheral Blood Gamma Delta T Cells by Tomchuck, Suzanne L., PhD, Perko, Ross, MD, Evans, Scarlett, McKenna, Amy, Dash, Pradyot, PhD, DVM, Thomas, Paul, PhD, Dallas, Mari Hashitate, MD

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Piezo1 restrains proinflammatory response but is essential in T-cell–mediated immunopathology by Choi, Sung Hee, Santin, Alicia, Myers, Jay T, Kim, Byung-Gyu, Eid, Saada, Tomchuck, Suzanne L, Kingsley, Daniel T, Huang, Alex Y

“…Piezo1 is a mechanosensitive, nonselective Ca2+ channel that is broadly expressed in CD4+ T cells. Using lineage-specific Piezo1 knockout mice (Piezo1cKO), we…”
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Zoledronic Acid Induces the Proliferation of Human Cord Blood Gamma Delta T Cells Ex Vivo by Tomchuck, Suzanne L, He, Jin, Perko, Ross W., Evans, Scarlett, McKenna, Amy, Dash, Pradyot, Thomas, Paul, Dallas, Mari H

“…Cord blood (CB) T cells are known to be naïve cells, but can be activated to respond similar to adult peripheral blood (PB) T cells. Reports indicate that…”
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A New Mesenchymal Stem Cell by Waterman, Ruth S, Tomchuck, Suzanne L, Henkle, Sarah L, Betancourt, Aline M

“…Background Our laboratory and others reported that the stimulation of specific Toll-like receptors (TLRs) affects the immune modulating responses of human…”
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Umbilical Cord Blood Gamma Delta T Cell Characteristics are Important When Considering Their Use in Transplantation by Tomchuck, Suzanne L., Holland, Brooke S., Evans, Scarlett, Dallas, Mari Hashitate

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207 - Umbilical Cord Blood Gamma Delta T Cell Characteristics are Important When Considering Their Use in Transplantation by Tomchuck, Suzanne L., Holland, Brooke S., Evans, Scarlett, Dallas, Mari Hashitate

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