Search Results - "Tombaugh, G C"

Similar Propagation of SD and Hypoxic SD-Like Depolarization in Rat Hippocampus Recorded Optically and Electrically by Aitken, P. G, Tombaugh, G. C, Turner, D. A, Somjen, G. G

“…P. G. Aitken 1 , G. C. Tombaugh 1 , D. A. Turner 2 , 3 , 4 , and G. G. Somjen 1 , 2 1  Department of Cell Biology, 2  Department of Neurobiology, and 3…”
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Effects of extracellular pH on voltage-gated Na+, K+ and Ca2+ currents in isolated rat CA1 neurons by Tombaugh, G C, Somjen, G G

“…1. The effects of extracellular H+ (pHo) in the pathophysiological range (pH 6-8) on voltage-gated sodium, potassium, and calcium currents were examined in…”
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Evolving concepts about the role of acidosis in ischemic neuropathology by Tombaugh, G C, Sapolsky, R M

“…Cerebral ischemia is one of the most common neurological insults. Many pathological events are undoubtedly triggered by ischemia, but only recently has it…”
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Corticosterone accelerates hypoxia- and cyanide-induced ATP loss in cultured hippocampal astrocytes by Tombaugh, G C, Sapolsky, R M

“…Glucocorticoids potentiate injury to the rodent hippocampus following a variety of metabolic insults, including hypoxia/ischemia, both in vitro and in vivo. We…”
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Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity by Virgin, Jr, C E, Ha, T P, Packan, D R, Tombaugh, G C, Yang, S H, Horner, H C, Sapolsky, R M

“…Glucocorticoids (GCs), the adrenal steroid hormones secreted during stress, can damage the hippocampus and impair its capacity to survive coincident…”
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Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation by Tombaugh, G C, Sapolsky, R M

“…Hippocampal neurons are extremely sensitive to ischemic injury; two plausible mechanisms have been implicated in mediating such damage. The first involves…”
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Theta-Frequency Synaptic Potentiation in CA1 In Vitro Distinguishes Cognitively Impaired from Unimpaired Aged Fischer 344 Rats by Tombaugh, Geoffrey C, Rowe, Wayne B, Chow, Ana R, Michael, Timothy H, Rose, Gregory M

“…Hippocampal-dependent learning and memory deficits have been well documented in aging rodents. The results of several recent studies have suggested that these…”
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Hippocampal glutamine synthetase: insensitivity to glucocorticoids and stress by Tombaugh, G C, Sapolsky, R M

“…Glucocorticoids enhance the neurotoxic potential of several insults to the rat hippocampus that involve overactivation of glutamatergic synapses. These…”
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Intracellular pH Buffering Shapes Activity-Dependent Ca2+ Dynamics in Dendrites of CA1 Interneurons by Tombaugh, Geoffrey C

“…Geoffrey C. Tombaugh Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 Tombaugh, Geoffrey C.  Intracellular pH buffering…”
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Differential Sensitivity to Intracellular pH Among High- and Low-Threshold Ca2+ Currents in Isolated Rat CA1 Neurons by Tombaugh, Geoffrey C, Somjen, George G

“…Geoffrey C. Tombaugh and George G. Somjen Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 Tombaugh, Geoffrey C. and…”
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Endocrine features of glucocorticoid endangerment in hippocampal astrocytes by Tombaugh, G C, Sapolsky, R M

“…Metabolic insults, such as ischemia or hypoglycemia, typically cause severe neuronal injury in the hippocampus and this cell vulnerability can be exacerbated…”
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Glucocorticoids exacerbate hypoxic and hypoglycemic hippocampal injury in vitro: biochemical correlates and a role for astrocytes by Tombaugh, G C, Yang, S H, Swanson, R A, Sapolsky, R M

“…The acute secretion of glucocorticoids is critical for responding to physiological stress. Under normal circumstances these hormones do not cause acute…”
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Excitotoxic neuron death, acidotic endangerment, and the paradox of acidotic protection by Sapolsky, R M, Trafton, J, Tombaugh, G C

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Mild acidosis delays hypoxic spreading depression and improves neuronal recovery in hippocampal slices by Tombaugh, GC

“…Severe tissue acidosis has been viewed traditionally as a damaging component of cerebral hypoxia. However, a neuroprotective action of low pH during hypoxia…”
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Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia by Tombaugh, G C, Sapolsky, R M

“…Excitotoxicity is believed to underlie the selective loss of vulnerable neurons after transient ischemia, while lactic acidosis seems to be the principal…”
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Heptanol But Not Fluoroacetate Prevents the Propagation of Spreading Depression in Rat Hippocampal Slices by Largo, Carlota, Tombaugh, Geoffrey C, Aitken, Peter G, Herreras, Oscar, Somjen, George G

“…Carlota Largo 1 , Geoffrey C. Tombaugh 2 , Peter G. Aitken 2 , Oscar Herreras 1 , and George G. Somjen 2 1  Depto de Investigación, Hospital Ramón y Cajal,…”
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The Slow Afterhyperpolarization in Hippocampal CA1 Neurons Covaries with Spatial Learning Ability in Aged Fisher 344 Rats by Tombaugh, Geoffrey C, Rowe, Wayne B, Rose, Gregory M

“…Rodents commonly exhibit age-related impairments in spatial learning tasks, deficits widely thought to reflect cellular or synaptic dysfunction in the…”
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Intracellular pH buffering shapes activity-dependent Ca super(2+) Dynamics in dendrites of CA1 interneurons by Tombaugh, G C

“…Voltage-gated calcium (Ca) channels are highly sensitive to cytosolic H super(+), and Ca super(2+) influx through these channels triggers an activity-dependent…”
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Venn diagrams and neuronal vulnerability by Sapolsky, R M, Morrow, E A, Tombaugh, G C

“…Greenamyre and Young note that there is poor correlation between which hippocampal regions are damaged in Alzheimer's disease and which have the highest…”
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Differential sensitivity to intracellular pH among high- and low-threshold Ca super(2+) currents in isolated rat CA1 neurons by Tombaugh, G C, Somjen, G G

“…The effects of intracellular pH (pH sub(i)) on high-threshold (HVA) and low-threshold (LVA) calcium currents were examined in acutely dissociated rat…”
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