Search Results - "Tomaz, Rute A"

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo by Rashidi, Hassan, Luu, Nguyet-Thin, Alwahsh, Salamah M., Ginai, Maaria, Alhaque, Sharmin, Dong, Hua, Tomaz, Rute A., Vernay, Bertrand, Vigneswara, Vasanthy, Hallett, John M., Chandrashekran, Anil, Dhawan, Anil, Vallier, Ludovic, Bradley, Mark, Callanan, Anthony, Forbes, Stuart J., Newsome, Philip N., Hay, David C.

“…Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the…”
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Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency by Bell, Emma, Curry, Edward W., Megchelenbrink, Wout, Jouneau, Luc, Brochard, Vincent, Tomaz, Rute A., Mau, King Hang T., Atlasi, Yaser, de Souza, Roshni A., Marks, Hendrik, Stunnenberg, Hendrik G., Jouneau, Alice, Azuara, Véronique

“…Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they…”
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Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming by Percharde, Michelle, Lavial, Fabrice, Ng, Jia-Hui, Kumar, Vibhor, Tomaz, Rute A, Martin, Nadine, Yeo, Jia-Chi, Gil, Jesús, Prabhakar, Shyam, Ng, Huck-Hui, Parker, Malcolm G, Azuara, Véronique

“…Embryonic stem cell (ESC) pluripotency depends on a well-characterized gene regulatory network centered on Oct4, Sox2, and Nanog. In contrast, little is known…”
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Generation of functional hepatocytes by forward programming with nuclear receptors by Tomaz, Rute A, Zacharis, Ekaterini D, Bachinger, Fabian, Wurmser, Annabelle, Yamamoto, Daniel, Petrus-Reurer, Sandra, Morell, Carola M, Dziedzicka, Dominika, Wesley, Brandon T, Geti, Imbisaat, Segeritz, Charis-Patricia, de Brito, Miguel C, Chhatriwala, Mariya, Ortmann, Daniel, Saeb-Parsy, Kourosh, Vallier, Ludovic

“…Production of large quantities of hepatocytes remains a major challenge for a number of clinical applications in the biomedical field. Directed differentiation…”
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Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics by Yiangou, Loukia, Grandy, Rodrigo A., Morell, Carola M., Tomaz, Rute A., Osnato, Anna, Kadiwala, Juned, Muraro, Daniele, Garcia-Bernardo, Jose, Nakanoh, Shota, Bernard, William G., Ortmann, Daniel, McCarthy, Davis J., Simonic, Ingrid, Sinha, Sanjay, Vallier, Ludovic

“…Cell cycle progression and cell fate decisions are closely linked in human pluripotent stem cells (hPSCs). However, the study of these interplays at the…”
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Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development by Lavial, Fabrice, Bessonnard, Sylvain, Ohnishi, Yusuke, Tsumura, Akiko, Chandrashekran, Anil, Fenwick, Mark A, Tomaz, Rute A, Hosokawa, Hiroyuki, Nakayama, Toshinori, Chambers, Ian, Hiiragi, Takashi, Chazaud, Claire, Azuara, Véronique

“…The transcription factors Nanog and Gata6 are critical to specify the epiblast versus primitive endoderm (PrE) lineages. However, little is known about the…”
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Modeling Disease with Human Inducible Pluripotent Stem Cells by Grandy, Rodrigo, Tomaz, Rute A, Vallier, Ludovic

“…Understanding the physiopathology of disease remains an essential step in developing novel therapeutics. Although animal models have certainly contributed to…”
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Single-cell atlas of human liver development reveals pathways directing hepatic cell fates by Wesley, Brandon T., Ross, Alexander D. B., Muraro, Daniele, Miao, Zhichao, Saxton, Sarah, Tomaz, Rute A., Morell, Carola M., Ridley, Katherine, Zacharis, Ekaterini D., Petrus-Reurer, Sandra, Kraiczy, Judith, Mahbubani, Krishnaa T., Brown, Stephanie, Garcia-Bernardo, Jose, Alsinet, Clara, Gaffney, Daniel, Horsfall, Dave, Tysoe, Olivia C., Botting, Rachel A., Stephenson, Emily, Popescu, Dorin-Mirel, MacParland, Sonya, Bader, Gary, McGilvray, Ian D., Ortmann, Daniel, Sampaziotis, Fotios, Saeb-Parsy, Kourosh, Haniffa, Muzlifah, Stevens, Kelly R., Zilbauer, Matthias, Teichmann, Sarah A., Vallier, Ludovic

“…The liver has been studied extensively due to the broad number of diseases affecting its vital functions. However, therapeutic advances have been hampered by…”
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Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation by Ortmann, Daniel, Brown, Stephanie, Czechanski, Anne, Aydin, Selcan, Muraro, Daniele, Huang, Yuanhua, Tomaz, Rute A., Osnato, Anna, Canu, Giovanni, Wesley, Brandon T., Skelly, Daniel A., Stegle, Oliver, Choi, Ted, Churchill, Gary A., Baker, Christopher L., Rugg-Gunn, Peter J., Munger, Steven C., Reinholdt, Laura G., Vallier, Ludovic

“…Variability among pluripotent stem cell (PSC) lines is a prevailing issue that hampers not only experimental reproducibility but also large-scale applications…”
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FOXE1 polymorphisms are associated with familial and sporadic nonmedullary thyroid cancer susceptibility by Tomaz, Rute A., Sousa, Inês, Silva, Joana G., Santos, Catarina, Teixeira, Manuel R., Leite, Valeriano, Cavaco, Branca M.

“…Summary Objective FOXE1 is a transcription factor required for thyroid differentiation and function. FOXE1 locus polymorphisms (chromosome 9q22.33) were…”
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Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation by Tomaz, Rute A, Harman, Jennifer L, Karimlou, Donja, Weavers, Lauren, Fritsch, Lauriane, Bou-Kheir, Tony, Bell, Emma, Del Valle Torres, Ignacio, Niakan, Kathy K, Fisher, Cynthia, Joshi, Onkar, Stunnenberg, Hendrik G, Curry, Edward, Ait-Si-Ali, Slimane, Jørgensen, Helle F, Azuara, Véronique

“…Jmjd2 H3K9 demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about their importance at the exit of ESC…”
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Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance by Coll, Anthony P., Chen, Michael, Taskar, Pranali, Rimmington, Debra, Patel, Satish, Tadross, John A., Cimino, Irene, Yang, Ming, Welsh, Paul, Virtue, Samuel, Goldspink, Deborah A., Miedzybrodzka, Emily L., Konopka, Adam R., Esponda, Raul Ruiz, Huang, Jeffrey T.-J., Tung, Y. C. Loraine, Rodriguez-Cuenca, Sergio, Tomaz, Rute A., Harding, Heather P., Melvin, Audrey, Yeo, Giles S. H., Preiss, David, Vidal-Puig, Antonio, Vallier, Ludovic, Nair, K. Sreekumaran, Wareham, Nicholas J., Ron, David, Gribble, Fiona M., Reimann, Frank, Sattar, Naveed, Savage, David B., Allan, Bernard B., O’Rahilly, Stephen

“…An Amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Differential methylation as a cause of allele dropout at the imprinted GNAS locus by Tomaz, Rute A, Cavaco, Branca M, Leite, Valeriano

“…We detected false homozygosity at the NESP55 differentially methylated region of the imprinted GNAS locus while analyzing the segregation of single-nucleotide…”
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GDF15 mediates the effects of metformin on body weight and energy balance by Coll, Anthony P., Chen, Michael, Taskar, Pranali, Rimmington, Debra, Patel, Satish, Tadross, John A., Cimino, Irene, Yang, Ming, Welsh, Paul, Virtue, Samuel, Goldspink, Deborah A., Miedzybrodzka, Emily L., Konopka, Adam R., Esponda, Raul Ruiz, Huang, Jeffrey T.-J., Tung, Y. C. Loraine, Rodriguez-Cuenca, Sergio, Tomaz, Rute A., Harding, Heather P., Melvin, Audrey, Yeo, Giles S. H., Preiss, David, Vidal-Puig, Antonio, Vallier, Ludovic, Nair, K. Sreekumaran, Wareham, Nicholas J., Ron, David, Gribble, Fiona M., Reimann, Frank, Sattar, Naveed, Savage, David B., Allan, Bernard B., O’Rahilly, Stephen

“…Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk 1 , 2 . More than 60% of this…”
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Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids by Rimland, Casey A., Tilson, Samantha G., Morell, Carola M., Tomaz, Rute A., Lu, Wei‐Yu, Adams, Simone E., Georgakopoulos, Nikitas, Otaizo‐Carrasquero, Francisco, Myers, Timothy G., Ferdinand, John R., Gieseck, Richard L., Sampaziotis, Fotios, Tysoe, Olivia C., Ross, Alexander, Kraiczy, Judith M., Wesley, Brandon, Muraro, Daniele, Zilbauer, Matthias, Oniscu, Gabriel C., Hannan, Nicholas R.F., Forbes, Stuart J., Saeb‐Parsy, Kourosh, Wynn, Thomas A., Vallier, Ludovic

“…Background and Aims Organoids provide a powerful system to study epithelia in vitro. Recently, this approach was applied successfully to the biliary tree, a…”
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