Search Results - "Tomasi, Thomas B"

Dicer is regulated by cellular stresses and interferons by Wiesen, Jennifer L., Tomasi, Thomas B.

“…The generation of microRNAs is dependent on the RNase III enzyme Dicer, the levels of which vary in different normal cells and in disease states. We…”
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Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells by Khan, A. Nazmul H., Gregorie, Christopher J., Tomasi, Thomas B.

“…Histone deacetylase inhibitors (HDACi), including trichostatin A (TSA) and valproic acid, can alter the acetylation of histones in chromatin and enhance gene…”
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The epigenetic regulation of Dicer and microRNA biogenesis by Panobinostat by Hoffend, Nicholas C., Magner, William J., Tomasi, Thomas B.

“…microRNAs (miRs) are small noncoding RNAs that regulate/fine tune many cellular protein networks by targeting mRNAs for either degradation or translational…”
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Mild hyperthermia enhances the expression and induces oscillations in the Dicer protein by Oshlag, Julian Z, Devasthanam, Anand S, Tomasi, Thomas B

“…To investigate whether mild heat stress at 39.5°C altered Dicer protein and miRNA expression patterns in several cell types. Multiple human and mouse cell…”
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The Heat Shock Protein 90-CDC37 Chaperone Complex Is Required for Signaling by Types I and II Interferons by Shang, Limin, Tomasi, Thomas B.

“…Interferon signaling pathways are critical to both innate and adaptive immunity. We have demonstrated here that the inhibition of heat shock protein 90 (Hsp90)…”
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Activation of MHC Class I, II, and CD40 Gene Expression by Histone Deacetylase Inhibitors by Magner, William J, Kazim, A. Latif, Stewart, Carleton, Romano, Michelle A, Catalano, Geoffrey, Grande, Catherine, Keiser, Nicholas, Santaniello, Frank, Tomasi, Thomas B

“…Epigenetic mechanisms are involved in regulating chromatin structure and gene expression through repression. In this study, we show that histone deacetylase…”
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An epigenetic vaccine model active in the prevention and treatment of melanoma by Khan, A Nazmul H, Magner, William J, Tomasi, Thomas B

“…Numerous immune genes are epigenetically silenced in tumor cells and agents such as histone deacetylase inhibitors (HDACi), which reverse these effects, could…”
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Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and antigen presentation in tumor cells by Chou, Shiuh-Dih, Khan, A. Nazmul H., Magner, William J., Tomasi, Thomas B.

“…The regulation of MHC class II expression by the class II transactivator (CIITA) is complex and differs in various cell types depending on the relative…”
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miRNA regulation of cytokine genes by Asirvatham, Ananthi J., Magner, William J., Tomasi, Thomas B.

“…In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs…”
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Dicer and microRNA expression in multiple sclerosis and response to interferon therapy by Magner, William J, Weinstock-Guttman, Bianca, Rho, Mina, Hojnacki, David, Ghazi, Rabia, Ramanathan, Murali, Tomasi, Thomas B

“…Abstract Dysregulation of microRNA expression has been shown in multiple sclerosis (MS); however, the mechanisms underlying these changes, their response to…”
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VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients by Khan, ANM Nazmul H., Emmons, Tiffany R., Magner, William J., Alqassim, Emad, Singel, Kelly L., Ricciuti, Jason, Eng, Kevin H., Odunsi, Kunle, Tomasi, Thomas B., Lee, Kelvin, Abrams, Scott I., Mesa, Circe, Segal, Brahm H.

“…The ovarian tumor microenvironment (TME) is characterized by the accumulation of immunosuppressive tumor-associated macrophages (TAMs) and granulocytic cells…”
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MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components by Asirvatham, Ananthi J., Gregorie, Christopher J., Hu, Zihua, Magner, William J., Tomasi, Thomas B.

“…We studied 613 genes which regulate immunity and, utilizing predictive algorithms, identified 285 genes as microRNA (miRNA or miR) targets. Of these, ∼250 are…”
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Dicer in immune cell development and function by Devasthanam, Anand S., Tomasi, Thomas B.

“…Dicer is an enzyme of the RNase III endoribonuclease family, which is crucial for RNA interference (RNAi) in eukaryotes. Dicer is a component of the protein…”
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The modulation of Dicer regulates tumor immunogenicity in melanoma by Hoffend, Nicholas C, Magner, William J, Tomasi, Thomas B

“…MicroRNAs (miRs) are small non-coding RNAs that regulate most cellular protein networks by targeting mRNAs for translational inhibition or degradation. Dicer,…”
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Epigenetic regulation of immune escape genes in cancer by TOMASI, Thomas B, MAGNER, William J, KHAN, A. Nazmul H

“…According to the concept of immune surveillance, the appearance of a tumor indicates that it has earlier evaded host defenses and subsequently must have…”
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Dicer protein levels elevated by mild hyperthermia promote a pro-survival phenotype by Devasthanam, Anand S, Tomasi, Thomas B

“…Cellular exposure to mild stress (39.5°C - 41.5°C) induces thermotolerance, rendering cells resistant to a subsequent heat shock (>42°C) insult. We found that…”
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Dicer protein levels elevated by mild hyperthermia promote a pro-survival phenotype by Devasthanam, Anand S., Tomasi, Thomas B.

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Histone deacetylase regulation of immune gene expression in tumor cells by Khan, A. Nazmul H., Tomasi, Thomas B.

“…Epigenetic modifications of chromatin, such as histone acetylation, are involved in repression of tumor antigens and multiple immune genes that are thought to…”
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Spatial distribution of histone methylation during MHC class II expression by Chou, Shiuh-Dih, Tomasi, Thomas B.

“…We have previously reported that Major Histocompatibility Complex (MHC) class II can be induced by histone deacetylase inhibitors (HDACi) in the absence of…”
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Exosomes from plasmacytoma cells as a tumor vaccine by ALTIERI, Stephen L, KHAN, A. Nazmul H, TOMASI, Thomas B

“…Exosomes are membrane-bound vesicles derived from multivesicular bodies that are externalized by cells through fusion with the plasma membrane. Exosomes have…”
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