Search Results - "Tomasetti, Cristian"

Mutated clones are the new normal by Tomasetti, Cristian

“…Measuring and understanding the dynamics of clonal cell populations is key for cancer prevention Cancers are formed by the expansion of harmful “mutational…”
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Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention by Tomasetti, Cristian, Li, Lu, Vogelstein, Bert

“…Cancers are caused by mutations that may be inherited, induced by environmental factors, or result from DNA replication errors (R). We studied the relationship…”
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Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation by Tomasetti, Cristian, Vogelstein, Bert, Parmigiani, Giovanni

“…Although it has been hypothesized that some of the somatic mutations found in tumors may occur before tumor initiation, there is little experimental or…”
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Only three driver gene mutations are required for the development of lung and colorectal cancers by Tomasett, Cristiani, Marchionni, Luigi, Nowak, Martin A., Parmigiani, Giovanni, Vogelstein, Bert

“…Significance The number of driver events required for human tumorigenesis has remained one of the fundamental issues in cancer research since the seminal…”
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Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer by Tie, Jeanne, Cohen, Joshua D., Lahouel, Kamel, Lo, Serigne N., Wang, Yuxuan, Kosmider, Suzanne, Wong, Rachel, Shapiro, Jeremy, Lee, Margaret, Harris, Sam, Khattak, Adnan, Burge, Matthew, Harris, Marion, Lynam, James, Nott, Louise, Day, Fiona, Hayes, Theresa, McLachlan, Sue-Anne, Lee, Belinda, Ptak, Janine, Silliman, Natalie, Dobbyn, Lisa, Popoli, Maria, Hruban, Ralph, Lennon, Anne Marie, Papadopoulos, Nicholas, Kinzler, Kenneth W., Vogelstein, Bert, Tomasetti, Cristian, Gibbs, Peter

“…In a randomized, controlled trial, a ctDNA-guided approach to the postsurgical treatment of stage II colon cancer reduced adjuvant chemotherapy use without…”
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Role of symmetric and asymmetric division of stem cells in developing drug resistance by Tomasetti, Cristian, Levy, Doron

“…Often, resistance to drugs is an obstacle to a successful treatment of cancer. In spite of the importance of the problem, the actual mechanisms that control…”
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Cancer prevention: Molecular and epidemiologic consensus by Song, Mingyang, Vogelstein, Bert, Giovannucci, Edward L, Willett, Walter C, Tomasetti, Cristian

“…Research in many fields emphasizes the value of prevention Prevention of any disease can occur at two levels: (i) avoiding or reducing risk factors coupled…”
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Evaluating cancer etiology and risk with a mathematical model of tumor evolution by Pénisson, Sophie, Lambert, Amaury, Tomasetti, Cristian

“…Recent evidence arising from DNA sequencing of healthy human tissues has clearly indicated that our organs accumulate a relevant number of somatic mutations…”
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Detection and localization of surgically resectable cancers with a multi-analyte blood test by Cohen, Joshua D, Li, Lu, Wang, Yuxuan, Thoburn, Christopher, Afsari, Bahman, Danilova, Ludmila, Douville, Christopher, Javed, Ammar A, Wong, Fay, Mattox, Austin, Hruban, Ralph H, Wolfgang, Christopher L, Goggins, Michael G, Dal Molin, Marco, Wang, Tian-Li, Roden, Richard, Klein, Alison P, Ptak, Janine, Dobbyn, Lisa, Schaefer, Joy, Silliman, Natalie, Popoli, Maria, Vogelstein, Joshua T, Browne, James D, Schoen, Robert E, Brand, Randall E, Tie, Jeanne, Gibbs, Peter, Wong, Hui-Li, Mansfield, Aaron S, Jen, Jin, Hanash, Samir M, Falconi, Massimo, Allen, Peter J, Zhou, Shibin, Bettegowda, Chetan, Diaz, Jr, Luis A, Tomasetti, Cristian, Kinzler, Kenneth W, Vogelstein, Bert, Lennon, Anne Marie, Papadopoulos, Nickolas

“…Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels…”
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On the slope of the regression between stem cell divisions and cancer risk, and the lack of correlation between stem cell divisions and environmental factors-associated cancer risk by Tomasetti, Cristian, Vogelstein, Bert

“…Little et al. [1] misrepresent our findings [2] by making incorrect statements that are similar to those previously found in some media. The problem with these…”
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Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers by Cohen, Joshua D., Javed, Ammar A., Thoburn, Christopher, Wong, Fay, Tie, Jeanne, Gibbs, Peter, Schmidt, C. Max, Yip-Schneider, Michele T., Allen, Peter J., Schattner, Mark, Brand, Randall E., Singhi, Aatur D., Petersen, Gloria M., Hong, Seung-Mo, Kim, Song Cheol, Falconi, Massimo, Doglioni, Claudio, Weiss, Matthew J., Ahuja, Nita, He, Jin, Makary, Martin A., Maitra, Anirban, Hanash, Samir M., Molin, Marco Dal, Wang, Yuxuan, Li, Lu, Ptak, Janine, Dobbyn, Lisa, Schaefer, Joy, Silliman, Natalie, Popoli, Maria, Goggins, Michael G., Hruban, Ralph H., Wolfgang, Christopher L., Klein, Alison P., Tomasetti, Cristian, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Lennon, Anne Marie

“…The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future. Here we describe our efforts to develop a noninvasive blood test…”
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Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing by Hoang, Margaret L., Kinde, Isaac, Tomasetti, Cristian, McMahon, K. Wyatt, Rosenquist, Thomas A., Grollman, Arthur P., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas

“…We present the bottleneck sequencing system (BotSeqS), a next-generation sequencing method that simultaneously quantifies rare somatic point mutations across…”
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Cancer-Associated Mutations in Endometriosis without Cancer by Anglesio, Michael S, Papadopoulos, Nickolas, Ayhan, Ayse, Nazeran, Tayyebeh M, Noë, Michaël, Horlings, Hugo M, Lum, Amy, Jones, Siân, Senz, Janine, Seckin, Tamer, Ho, Julie, Wu, Ren-Chin, Lac, Vivian, Ogawa, Hiroshi, Tessier-Cloutier, Basile, Alhassan, Rami, Wang, Amy, Wang, Yuxuan, Cohen, Joshua D, Wong, Fontayne, Hasanovic, Adnan, Orr, Natasha, Zhang, Ming, Popoli, Maria, McMahon, Wyatt, Wood, Laura D, Mattox, Austin, Allaire, Catherine, Segars, James, Williams, Christina, Tomasetti, Cristian, Boyd, Niki, Kinzler, Kenneth W, Gilks, C. Blake, Diaz, Luis, Wang, Tian-Li, Vogelstein, Bert, Yong, Paul J, Huntsman, David G, Shih, Ie-Ming

“…Genetic analysis of endometriotic lesions from 39 patients revealed mutations in cancer driver genes in 26%. In some patients, the same mutation was present in…”
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Circulating tumor DNA dynamics and recurrence risk in patients undergoing curative intent resection of colorectal cancer liver metastases: A prospective cohort study by Tie, Jeanne, Wang, Yuxuan, Cohen, Joshua, Li, Lu, Hong, Wei, Christie, Michael, Wong, Hui Li, Kosmider, Suzanne, Wong, Rachel, Thomson, Benjamin, Choi, Julian, Fox, Adrian, Field, Kathryn, Burge, Matthew, Shannon, Jenny, Kotasek, Dusan, Tebbutt, Niall C, Karapetis, Christos, Underhill, Craig, Haydon, Andrew, Schaeffer, Joy, Ptak, Janine, Tomasetti, Cristian, Papadopoulos, Nicholas, Kinzler, Kenneth W, Vogelstein, Bert, Gibbs, Peter

“…In patients with resectable colorectal liver metastases (CRLM), the role of pre- and postoperative systemic therapy continues to be debated. Previous studies…”
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Detection of low-frequency DNA variants by targeted sequencing of the Watson and Crick strands by Cohen, Joshua D., Douville, Christopher, Dudley, Jonathan C., Mog, Brian J., Popoli, Maria, Ptak, Janine, Dobbyn, Lisa, Silliman, Natalie, Schaefer, Joy, Tie, Jeanne, Gibbs, Peter, Tomasetti, Cristian, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert

“…Identification and quantification of low-frequency mutations remain challenging despite improvements in the baseline error rate of next-generation sequencing…”
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Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma by Eich, Marie-Lisa, Rodriguez Pena, Maria Del Carmen, Springer, Simeon U., Taheri, Diana, Tregnago, Aline C., Salles, Daniela C., Bezerra, Stephania Martins, Cunha, Isabela W., Fujita, Kazutoshi, Ertoy, Dilek, Bivalacqua, Trinity J., Tomasetti, Cristian, Papadopoulos, Nickolas, Kinzler, Ken W., Vogelstein, Bert, Netto, George J.

“…Noninvasive approaches for early detection of bladder cancer are actively being investigated. We recently developed a urine- based molecular assay for the…”
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Prognostic significance of postsurgery circulating tumor DNA in nonmetastatic colorectal cancer: Individual patient pooled analysis of three cohort studies by Tie, Jeanne, Cohen, Joshua D., Lo, Serigne N., Wang, Yuxuan, Li, Lu, Christie, Michael, Lee, Margaret, Wong, Rachel, Kosmider, Suzanne, Skinner, Iain, Wong, Hui Li, Lee, Belinda, Burge, Matthew E., Yip, Desmond, Karapetis, Christos S., Price, Timothy J., Tebbutt, Niall C., Haydon, Andrew M., Ptak, Janine, Schaeffer, Mary J., Silliman, Natalie, Dobbyn, Lisa, Popoli, Maria, Tomasetti, Cristian, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Gibbs, Peter

“…Studies in multiple solid tumor types have demonstrated the prognostic significance of ctDNA analysis after curative intent surgery. A combined analysis of…”
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Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions by Wu, Ren‐Chin, Wang, Pei, Lin, Shiou‐Fu, Zhang, Ming, Song, Qianqian, Chu, Tiffany, Wang, Brant G, Kurman, Robert J, Vang, Russell, Kinzler, Kenneth, Tomasetti, Cristian, Jiao, Yuchen, Shih, Ie‐Ming, Wang, Tian‐Li

“…The clonal relationship between ovarian high‐grade serous carcinoma (HGSC) and its presumed precursor lesion, serous tubal intraepithelial carcinoma (STIC),…”
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Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers by Wang, Yuxuan, Li, Lu, Douville, Christopher, Cohen, Joshua D, Yen, Ting-Tai, Kinde, Isaac, Sundfelt, Karin, Kjær, Susanne K, Hruban, Ralph H, Shih, Ie-Ming, Wang, Tian-Li, Kurman, Robert J, Springer, Simeon, Ptak, Janine, Popoli, Maria, Schaefer, Joy, Silliman, Natalie, Dobbyn, Lisa, Tanner, Edward J, Angarita, Ana, Lycke, Maria, Jochumsen, Kirsten, Afsari, Bahman, Danilova, Ludmila, Levine, Douglas A, Jardon, Kris, Zeng, Xing, Arseneau, Jocelyne, Fu, Lili, Diaz, Jr, Luis A, Karchin, Rachel, Tomasetti, Cristian, Kinzler, Kenneth W, Vogelstein, Bert, Fader, Amanda N, Gilbert, Lucy, Papadopoulos, Nickolas

“…We report the detection of endometrial and ovarian cancers based on genetic analyses of DNA recovered from the fluids obtained during a routine Papanicolaou…”
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Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy by Springer, Simeon U, Chen, Chung-Hsin, Rodriguez Pena, Maria Del Carmen, Li, Lu, Douville, Christopher, Wang, Yuxuan, Cohen, Joshua David, Taheri, Diana, Silliman, Natalie, Schaefer, Joy, Ptak, Janine, Dobbyn, Lisa, Papoli, Maria, Kinde, Isaac, Afsari, Bahman, Tregnago, Aline C, Bezerra, Stephania M, VandenBussche, Christopher, Fujita, Kazutoshi, Ertoy, Dilek, Cunha, Isabela W, Yu, Lijia, Bivalacqua, Trinity J, Grollman, Arthur P, Diaz, Luis A, Karchin, Rachel, Danilova, Ludmila, Huang, Chao-Yuan, Shun, Chia-Tung, Turesky, Robert J, Yun, Byeong Hwa, Rosenquist, Thomas A, Pu, Yeong-Shiau, Hruban, Ralph H, Tomasetti, Cristian, Papadopoulos, Nickolas, Kinzler, Ken W, Vogelstein, Bert, Dickman, Kathleen G, Netto, George J

“…Current non-invasive approaches for detection of urothelial cancers are suboptimal. We developed a test to detect urothelial neoplasms using DNA recovered from…”
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