Search Results - "Tomaselli, Simona"

Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms by Pagano, Katiuscia, Tomaselli, Simona, Molinari, Henriette, Ragona, Laura

“…Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, with no cure and preventive therapy. Misfolding and extracellular aggregation…”
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Antibacterial Properties of Polyurethane Foams Additivated with Terpenes from a Bio-Based Polyol by Tomaselli, Simona, Bertini, Fabio, Cifarelli, Angelica, Vignali, Adriano, Ragona, Laura, Losio, Simona

“…Water-blown polyurethane (PU) foams were prepared by bio-polyols from epoxidized linseed oils and caprylic acid in combination with toluene diisocianate (TDI)…”
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Flexible Polyurethane Foams from Bio-Based Polyols: Prepolymer Synthesis and Characterization by Losio, Simona, Cifarelli, Angelica, Vignali, Adriano, Tomaselli, Simona, Bertini, Fabio

“…Bio-polyols (BPOs), characterized by a hydroxyl number up to around 90 mg KOH/g, narrow polydispersity index and relatively low molecular mass up to 2000…”
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The role of dynamics in modulating ligand exchange in intracellular lipid binding proteins by Ragona, Laura, Pagano, Katiuscia, Tomaselli, Simona, Favretto, Filippo, Ceccon, Alberto, Zanzoni, Serena, D'Onofrio, Mariapina, Assfalg, Michael, Molinari, Henriette

“…Lipids are essential for many biological processes and crucial in the pathogenesis of several diseases. Intracellular lipid-binding proteins (iLBPs) provide…”
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Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule by Pagano, Katiuscia, Torella, Rubben, Foglieni, Chiara, Bugatti, Antonella, Tomaselli, Simona, Zetta, Lucia, Presta, Marco, Rusnati, Marco, Taraboletti, Giulia, Colombo, Giorgio, Ragona, Laura

“…Fibroblast growth factors (FGFs) are recognized targets for the development of therapies against angiogenesis-driven diseases, including cancer. The formation…”
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Site-Specific Investigation of the Steady-State Kinetics and Dynamics of the Multistep Binding of Bile Acid Molecules to a Lipid Carrier Protein by Cogliati, Clelia, Ragona, Laura, D'Onofrio, Mariapina, Günther, Ulrich, Whittaker, Sara, Ludwig, Christian, Tomaselli, Simona, Assfalg, Michael, Molinari, Henriette

“…The investigation of multi‐site ligand–protein binding and multi‐step mechanisms is highly demanding. In this work, advanced NMR methodologies such as 2D…”
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Bile acid binding protein: a versatile host of small hydrophobic ligands for applications in the fields of MRI contrast agents and bio-nanomaterials by Pagano, Katiuscia, Tomaselli, Simona, Zanzoni, Serena, Assfalg, Michael, Molinari, Henriette, Ragona, Laura

“…During the last decade a growing amount of evidence has been obtained, supporting the role of the beta-clamshell family of intracellular lipid binding proteins…”
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Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors by Colombo, Giorgio, Margosio, Barbara, Ragona, Laura, Neves, Marco, Bonifacio, Silvia, Annis, Douglas S., Stravalaci, Matteo, Tomaselli, Simona, Giavazzi, Raffaella, Rusnati, Marco, Presta, Marco, Zetta, Lucia, Mosher, Deane F., Ribatti, Domenico, Gobbi, Marco, Taraboletti, Giulia

“…Endogenous inhibitors of angiogenesis, such as thrombospondin-1 (TSP-1), are promising sources of therapeutic agents to treat angiogenesis-driven diseases,…”
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Insights about the effect of composition, branching and molecular weight on the slow pyrolysis of xylose-based polysaccharides by Gargiulo, Valentina, Ferreiro, Ana Isabel, Giudicianni, Paola, Tomaselli, Simona, Costa, Mario, Ragucci, Raffaele, Alfe, Michela

“…This work provides insights into the relationship between the pyrolysis products distribution and the structural features of xylose-based hemicelluloses. Three…”
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Characterizing the Oligomers Distribution along the Aggregation Pathway of Amyloid Aβ1‐40 by NMR by Pagano, Katiuscia, De Rosa, Lucia, Tomaselli, Simona, Molinari, Henriette, D'Andrea, Luca Domenico, Ragona, Laura

“…This study delves into the early aggregation process of the Aβ1‐40 amyloid peptide, elucidating the associated oligomers distribution. Motivated by the…”
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The study of transient protein–nanoparticle interactions by solution NMR spectroscopy by Assfalg, Michael, Ragona, Laura, Pagano, Katiuscia, D'Onofrio, Mariapina, Zanzoni, Serena, Tomaselli, Simona, Molinari, Henriette

“…The rapid development of novel nanoscale materials for applications in biomedicine urges an improved characterization of the nanobio interfaces. Nanoparticles…”
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Molecular Basis of the Antiangiogenic Action of Rosmarinic Acid, a Natural Compound Targeting Fibroblast Growth Factor‐2/FGFR Interactions by Pagano, Katiuscia, Carminati, Laura, Tomaselli, Simona, Molinari, Henriette, Taraboletti, Giulia, Ragona, Laura

“…Fibroblast growth factor (FGF2)/fibroblast growth factor receptor (FGFR) signalling plays a major role both in physiology and in several pathologies, including…”
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The Role of the Hinge Loop in Domain Swapping by Picone, Delia, Di Fiore, Anna, Ercole, Carmine, Franzese, Marisa, Sica, Filomena, Tomaselli, Simona, Mazzarella, Lelio

“…Bovine seminal ribonuclease (BS-RNase) is a covalent homodimeric enzyme homologous to pancreatic ribonuclease (RNase A), endowed with a number of special…”
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Bacteria as sensors: Real-time NMR analysis of extracellular metabolites detects sub-lethal amounts of bactericidal molecules released from functionalized materials by Tomaselli, Simona, Pasini, Mariacecilia, Kozma, Erika, Giovanella, Umberto, Scavia, Guido, Pagano, Katiuscia, Molinari, Henriette, Iannace, Salvatore, Ragona, Laura

“…Cells exposed to stress factors experience time-dependent variations of metabolite concentration, acting as reliable sensors of the effective concentration of…”
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Front Cover: Molecular Basis of the Antiangiogenic Action of Rosmarinic Acid, a Natural Compound Targeting Fibroblast Growth Factor‐2/FGFR Interactions (ChemBioChem 1/2021) by Pagano, Katiuscia, Carminati, Laura, Tomaselli, Simona, Molinari, Henriette, Taraboletti, Giulia, Ragona, Laura

“…Less complex: Right: Fibroblast growth factor‐2 (FGF2, orange) interacts with the extracellular domain of fibroblast growth factor receptor (FGFR, red/blue)…”
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Characterizing the oligomers distribution along the aggregation pathway of amyloid Aß1-40 by NMR by Pagano, Katiuscia, De Rosa, Lucia, Tomaselli, Simona, Molinari, Henriette, D'Andrea, Luca Domenico, Ragona, Laura

“…This study delves into the early aggregation process of the Aβ1-40 amyloid peptide, elucidating the associated oligomers distribution. Motivated by the…”
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Biophysical and in Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Aβ Oligomerization in Vitro and Aβ Oligomer-Mediated Memory Impairment and Neuroinflammation in an Acute Mouse Model of Alzheimer’s Disease by Tomaselli, Simona, La Vitola, Pietro, Pagano, Katiuscia, Brandi, Edoardo, Santamaria, Giulia, Galante, Denise, D’Arrigo, Cristina, Moni, Lisa, Lambruschini, Chiara, Banfi, Luca, Lucchetti, Jacopo, Fracasso, Claudia, Molinari, Henriette, Forloni, Gianluigi, Balducci, Claudia, Ragona, Laura

“…In this study natural-based complex polyphenols, obtained through a smart synthetic approach, have been evaluated for their ability to inhibit the formation of…”
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Lipid binding protein response to a bile acid library: a combined NMR and statistical approach by Tomaselli, Simona, Pagano, Katiuscia, Boulton, Stephen, Zanzoni, Serena, Melacini, Giuseppe, Molinari, Henriette, Ragona, Laura

“…Primary bile acids, differing in hydroxylation pattern, are synthesized from cholesterol in the liver and, once formed, can undergo extensive enzyme‐catalysed…”
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Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity by Pagano, Katiuscia, Galante, Denise, D’Arrigo, Cristina, Corsaro, Alessandro, Nizzari, Mario, Florio, Tullio, Molinari, Henriette, Tomaselli, Simona, Ragona, Laura

“…Soluble Aβ oligomers are widely recognized as the toxic forms responsible for triggering AD, and Aβ receptors are hypothesized to represent the first step in a…”
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Electrospun Lipid Binding Proteins Composite Nanofibers with Antibacterial Properties by Tomaselli, Simona, Ramirez, Diego Omar Sanchez, Carletto, Riccardo Andrea, Varesano, Alessio, Vineis, Claudia, Zanzoni, Serena, Molinari, Henriette, Ragona, Laura

“…Electrospinning is here used for the first time to prepare nanofibers including a host/guest complex in a keratin/poly(ethylene oxide) matrix. The host is a…”
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