Search Results - "Tomaras, Georgia"
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Complex immune correlates of protection in HIV‐1 vaccine efficacy trials
Published in Immunological reviews (01-01-2017)“…Summary Development of an efficacious HIV‐1 vaccine is a major priority for improving human health worldwide. Vaccine‐mediated protection against human…”
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Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial
Published in PLoS medicine (14-11-2017)“…VRC01 is an HIV-1 CD4 binding site broadly neutralizing antibody (bnAb) that is active against a broad range of HIV-1 primary isolates in vitro and protects…”
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3
Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies
Published in PLoS pathogens (24-02-2020)“…Antibody functions such as neutralization require recognition of antigen by the Fab region, while effector functions are additionally mediated by interactions…”
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The immune response during acute HIV-1 infection: clues for vaccine development
Published in Nature reviews. Immunology (01-01-2010)“…Key Points The early virological factors in HIV-1 infection, including transmission and the nature of the founder virus, can affect the time course of viraemia…”
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Bringing the path toward an HIV-1 vaccine into focus
Published in PLoS pathogens (10-09-2020)“…About the Authors: Cesar J. Lopez Angel Affiliations Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California,…”
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Immune correlates of vaccine protection against HIV-1 acquisition
Published in Science translational medicine (21-10-2015)“…The partial efficacy reported in the RV144 HIV vaccine trial in 2009 has driven the HIV vaccine field to define correlates of risk associated with HIV-1…”
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Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses
Published in PLoS pathogens (01-08-2016)“…Emerging data support a role for antibody Fc-mediated antiviral activity in vaccine efficacy and in the control of HIV-1 replication by broadly neutralizing…”
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Combination therapy with anti-HIV-1 antibodies maintains viral suppression
Published in Nature (London) (01-09-2018)“…Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a…”
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Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG
Published in Proceedings of the National Academy of Sciences - PNAS (28-05-2013)“…Analysis of correlates of risk of infection in the RV144 HIV-1 vaccine efficacy trial demonstrated that plasma IgG against the HIV-1 envelope (Env) variable…”
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Human gut microbiota is associated with HIV-reactive immunoglobulin at baseline and following HIV vaccination
Published in PloS one (23-12-2019)“…Antibodies that recognize commensal microbial antigens may be cross reactive with a part of the human immunodeficiency virus (HIV) envelope glycoprotein gp41…”
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Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk
Published in PLoS pathogens (15-03-2021)“…The pox-protein regimen tested in the RV144 trial is the only vaccine strategy demonstrated to prevent HIV-1 infection. Subsequent analyses identified antibody…”
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Non-neutralizing SARS-CoV-2 N-terminal domain antibodies protect mice against severe disease using Fc-mediated effector functions
Published in PLoS pathogens (20-06-2024)“…Antibodies perform both neutralizing and non-neutralizing effector functions that protect against certain pathogen-induced diseases. A human antibody directed…”
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CD8+ T cells: mechanistic target of rapamycin and eukaryotic initiation factor 2 in elite HIV-1 control
Published in AIDS (London) (28-11-2018)Get full text
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Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV
Published in Nature medicine (01-10-2018)“…Antibodies are the primary correlate of protection for most licensed vaccines; however, their mechanisms of protection may vary, ranging from physical blockade…”
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Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
Published in Cell host & microbe (13-11-2019)“…Potent and broadly neutralizing antibodies (bnAbs) are the hallmark of HIV-1 protection by vaccination. The membrane-proximal external region (MPER) of the…”
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Parameter estimation and identifiability analysis for a bivalent analyte model of monoclonal antibody-antigen binding
Published in Analytical biochemistry (15-10-2023)“…Surface plasmon resonance (SPR) is an extensively used technique to characterize antigen-antibody interactions. Affinity measurements by SPR typically involve…”
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Vi-specific serological correlates of protection for typhoid fever
Published in The Journal of experimental medicine (01-02-2021)“…Typhoid Vi vaccines have been shown to be efficacious in children living in endemic regions; however, a widely accepted correlate of protection remains to be…”
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Vaccination establishes clonal relatives of germinal center T cells in the blood of humans
Published in The Journal of experimental medicine (03-07-2017)“…Germinal center T follicular helper cells (GCTfh) in lymphatic tissue are critical for B cell differentiation and protective antibody induction, but whether…”
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HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
Published in Nature communications (18-02-2019)“…The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium limits antigen uptake. Here we utilize a modified…”
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COMPASS identifies T-cell subsets correlated with clinical outcomes
Published in Nature biotechnology (01-06-2015)“…Computational analysis of antigen-specific T cell subsets highlights individual-level variation in immune response quality. Advances in flow cytometry and…”
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