Search Results - "Tomala, Jakub"

Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes by Klimova, Nela, Holubova, Jana, Streparola, Gaia, Tomala, Jakub, Brazdilova, Ludmila, Stanek, Ondrej, Bumba, Ladislav, Sebo, Peter

“…The adenylate cyclase (ACT) and the pertussis (PT) toxins of Bordetella pertussis exert potent immunomodulatory activities that synergize to suppress host…”
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Mr-compatible 12-lead ECG Recording During Atrial Flutter Ablation Procedure in the Interventional Cardiac Magnetic Resonance (iCMR) Suite: Exploring the Magnetohydrodynamic (MHD) Effect by Ulbrich, Stefan, Götz, Isabel, Tomala, Jakub, Gaspar, Thomas, Linke, Axel, Richter, Sergio

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Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells by Adkins, Irena, Sadilkova, Lenka, Hradilova, Nada, Tomala, Jakub, Kovar, Marek, Spisek, Radek

“…The mechanisms of immunogenicity underlying mild heat-shock (mHS) treatment < 42°C of tumor cells are largely attributed to the action of heat-shock proteins;…”
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IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25 + Foxp3 - T cells by Tomala, Jakub, Weberova, Petra, Tomalova, Barbora, Jiraskova Zakostelska, Zuzana, Sivak, Ladislav, Kovarova, Jirina, Kovar, Marek

“…Complexes of IL-2 and JES6-1 mAb (IL-2/JES6) provide strong sustained IL-2 signal selective for CD25 cells and thus they potently expand T cells. IL-2/JES6 are…”
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Left atrial fibrosis predicts left ventricular ejection fraction response after atrial fibrillation ablation in heart failure patients: the Fibrosis-HF Study by Kirstein, Bettina, Neudeck, Sebastian, Gaspar, Thomas, Piorkowski, Judith, Wechselberger, Simon, Kronborg, Mads Brix, Zedda, Angela, Hankel, Anastasia, El-Armouche, Ali, Tomala, Jakub, Schmidt, Thomas, Mayer, Julia, Wagner, Michael, Ulbrich, Stefan, Pu, Liying, Richter, Utz, Huo, Yan, Piorkowski, Christopher

“…Abstract Aims Atrial fibrillation (AF) and heart failure (HF) often coexist. Catheter ablation has been reported to restore left ventricular (LV) function but…”
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SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity by Antosova, Zuzana, Podzimkova, Nada, Tomala, Jakub, Augustynkova, Katerina, Sajnerova, Katerina, Nedvedova, Eva, Sirova, Milada, de Martynoff, Guy, Bechard, David, Moebius, Ulrich, Kovar, Marek, Spisek, Radek, Adkins, Irena

“…SOT101 is a superagonist fusion protein of interleukin (IL)-15 and the IL-15 receptor α (IL-15Rα) sushi+ domain, representing a promising clinical candidate…”
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Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells by Adkins, Irena, Kamanova, Jana, Kocourkova, Aneta, Svedova, Martina, Tomala, Jakub, Janova, Hana, Masin, Jiri, Chladkova, Barbora, Bumba, Ladislav, Kovar, Marek, Ross, Padraig J, Tuckova, Ludmila, Spisek, Radek, Mills, Kingston H G, Sebo, Peter

“…Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and…”
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Delivery of Large Heterologous Polypeptides across the Cytoplasmic Membrane of Antigen-Presenting Cells by the Bordetella RTX Hemolysin Moiety Lacking the Adenylyl Cyclase Domain by HOLUBOVA, Jana, KAMANOVA, Jana, SEBO, Peter, JELINEK, Jiri, TOMALA, Jakub, MASIN, Jiri, KOSOVA, Martina, STANEK, Ondrej, BUMBA, Ladislav, MICHALEK, Jaroslav, KOVAR, Marek

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy? by Tomala, Jakub, Kovar, Marek

“…The in vivo biological activity of IL-2 can be dramatically increased by complexing with anti-IL-2 mAb. Moreover, IL-2/anti-IL-2 mAb immunocomplexes…”
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Engineering Anticytokine Antibodies for Immune Modulation by Tomala, Jakub, Cao, Shanelle D, Spangler, Jamie B

“…The delicate balance of immune homeostasis is regulated by the interactions between cytokines and their cognate cell surface signaling receptors. There is…”
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Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate by Sivak, Ladislav, Subr, Vladimir, Tomala, Jakub, Rihova, Blanka, Strohalm, Jiri, Etrych, Tomas, Kovar, Marek

“…Abstract Multidrug resistance (MDR) is a common cause of failure in chemotherapy for malignant diseases. MDR is either acquired as a result of previous…”
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IL-7/αIL-7 mAb M25 immunocomplexes expand CD8+ T cells but paradoxically abrogate the antitumor activity of CTLA-4 and PD-1 blockage by Hrabos, Dominik, Hnizdilova, Tereza, Tomala, Jakub, Uhlik, Jiri, Kovar, Marek

“…•IL-7/M25 shift the CD8+:CD4+ T cell ratio in favor of CD8+ T cells.•IL-7/M25 and checkpoint inhibitors increase the infiltration of tumor by CD8+ T…”
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Characterization of Immune Cell Subset Expansion in Response to Therapeutic Treatment in Mice by Tomala, Jakub, Spangler, Jamie B

“…Flow cytometry has revolutionized the field of molecular immunology, enabling the monitoring and characterization of immune events at the single-cell level…”
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Kiosk 11R-TC-06 - Mr-compatible 12-lead ECG Recording During Atrial Flutter Ablation Procedure in the Interventional Cardiac Magnetic Resonance (iCMR) Suite: Exploring the Magnetohydrodynamic (MHD) Effect by Ulbrich, Stefan, Götz, Isabel, Tomala, Jakub, Gaspar, Thomas, Linke, Axel, Richter, Sergio

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Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera by Votavova, Petra, Tomala, Jakub, Kovar, Marek

“…Highlights • The in vivo biological activity of IL-2 can be increased by anti-IL-2 mAbs. • The in vivo biological activity of IL-15 can be increased by…”
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In Vivo Expansion of Activated Naive CD8+ T Cells and NK Cells Driven by Complexes of IL-2 and Anti-IL-2 Monoclonal Antibody As Novel Approach of Cancer Immunotherapy by Tomala, Jakub, Chmelova, Helena, Mrkvan, Tomas, Rihova, Blanka, Kovar, Marek

“…IL-2 is potent imunostimulatory molecule that plays a key role in T and NK cell activation and expansion. IL-2 is approved by the FDA to treat metastatic renal…”
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Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms by Spangler, Jamie B., Tomala, Jakub, Luca, Vincent C., Jude, Kevin M., Dong, Shen, Ring, Aaron M., Votavova, Petra, Pepper, Marion, Kovar, Marek, Garcia, K. Christopher

“…Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates immune cell homeostasis and has been used to treat a range of disorders including cancer and…”
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Combined in vitro and cell‐based selection display method producing specific binders against IL‐9 receptor in high yields by Huličiak, Maroš, Biedermanová, Lada, Berdár, Daniel, Herynek, Štěpán, Kolářová, Lucie, Tomala, Jakub, Mikulecký, Pavel, Schneider, Bohdan

“…We combined cell‐free ribosome display and cell‐based yeast display selection to build specific protein binders to the extracellular domain of the human…”
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Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy by Spangler, Jamie B, Trotta, Eleonora, Tomala, Jakub, Peck, Ariana, Young, Tracy A, Savvides, Christina S, Silveria, Stephanie, Votavova, Petra, Salafsky, Joshua, Pande, Vijay S, Kovar, Marek, Bluestone, Jeffrey A, Garcia, K Christopher

“…IL-2 has been used to treat diseases ranging from cancer to autoimmune disorders, but its concurrent immunostimulatory and immunosuppressive effects hinder…”
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Recurrence of Right Heart Failure After Heterotopic Tricuspid Intervention: A Conceptual Misunderstanding? by Wilbring, Manuel, Tomala, Jakub, Ulbrich, Stefan, Murugaboopathy, Viboosani, Matschke, Klaus, Kappert, Utz

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