Search Results - "Tomás, Helena"

Polyethylenimine Nanogels Incorporated with Ultrasmall Iron Oxide Nanoparticles and Doxorubicin for MR Imaging-Guided Chemotherapy of Tumors by Zou, Yu, Li, Du, Wang, Yue, Ouyang, Zhijun, Peng, Yucheng, Tomás, Helena, Xia, Jindong, Rodrigues, João, Shen, Mingwu, Shi, Xiangyang

“…Development of versatile nanoplatforms for cancer theranostics remains a hot topic in the area of nanomedicine. We report here a general approach to create…”
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Multifunctional Dendrimer-Entrapped Gold Nanoparticles Conjugated with Doxorubicin for pH-Responsive Drug Delivery and Targeted Computed Tomography Imaging by Zhu, Jingyi, Wang, Guoying, Alves, Carla S, Tomás, Helena, Xiong, Zhijuan, Shen, Mingwu, Rodrigues, João, Shi, Xiangyang

“…Novel theranostic nanocarriers exhibit a desirable potential to treat diseases based on their ability to achieve targeted therapy while allowing for real-time…”
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Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery by Li, Yulin, Maciel, Dina, Rodrigues, João, Shi, Xiangyang, Tomás, Helena

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Polysaccharide-based nanomedicines for cancer immunotherapy: A review by Zeng, Yujun, Xiang, Yufan, Sheng, Ruilong, Tomás, Helena, Rodrigues, João, Gu, Zhongwei, Zhang, Hu, Gong, Qiyong, Luo, Kui

“…Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics. However, direct…”
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RGD Peptide-Modified Dendrimer-Entrapped Gold Nanoparticles Enable Highly Efficient and Specific Gene Delivery to Stem Cells by Kong, Lingdan, Alves, Carla S, Hou, Wenxiu, Qiu, Jieru, Möhwald, Helmuth, Tomás, Helena, Shi, Xiangyang

“…We report the use of arginine-glycine-aspartic (Arg-Gly-Asp, RGD) peptide-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for highly efficient and…”
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Redox-Responsive Alginate Nanogels with Enhanced Anticancer Cytotoxicity by Maciel, Dina, Figueira, Priscilla, Xiao, Shili, Hu, Dengmai, Shi, Xiangyang, Rodrigues, João, Tomás, Helena, Li, Yulin

“…Although doxorubicin (Dox) has been widely used in the treatment of different types of cancer, its insufficient cellular uptake and intracellular release is…”
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Amphiphilic Polymer-Mediated Formation of Laponite-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery by Wang, Guoying, Maciel, Dina, Wu, Yilun, Rodrigues, João, Shi, Xiangyang, Yuan, Yuan, Liu, Changsheng, Tomás, Helena, Li, Yulin

“…The development of pH-sensitive drug delivery nanosystems that present a low drug release at the physiological pH and are able to increase the extent of the…”
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Volatile metabolomic signature of human breast cancer cell lines by Silva, Catarina L., Perestrelo, Rosa, Silva, Pedro, Tomás, Helena, Câmara, José S.

“…Breast cancer (BC) remains the most prevalent oncologic pathology in women, causing huge psychological, economic and social impacts on our society. Currently,…”
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Glycodendron/pyropheophorbide-a (Ppa)-functionalized hyaluronic acid as a nanosystem for tumor photodynamic therapy by Zhang, Xiaoqin, Wu, Yahui, Li, Zhiqian, Wang, Wenjia, Wu, Yaping, Pan, Dayi, Gu, Zhongwei, Sheng, Ruilong, Tomás, Helena, Zhang, Hu, Rodrigues, João, Gong, Qiyong, Luo, Kui

“…•A glycodendron/Ppa-functionalized HA was prepared for tumor photodynamic therapy.•Dendronized HA showed high tumor accumulation and excellent anticancer…”
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Zwitterion-functionalized dendrimer-entrapped gold nanoparticles for serum-enhanced gene delivery to inhibit cancer cell metastasis by Xiong, Zhijuan, Alves, Carla S., Wang, Jianhua, Li, Aijun, Liu, Jinyuan, Shen, Mingwu, Rodrigues, João, Tomás, Helena, Shi, Xiangyang

“…[Display omitted] We demonstrate a novel serum-enhanced gene delivery approach using zwitterion-functionalized dendrimer-entrapped gold nanoparticles (Au…”
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Why and how have drug discovery strategies in pharma changed? What are the new mindsets? by Mignani, Serge, Huber, Scot, Tomás, Helena, Rodrigues, João, Majoral, Jean-Pierre

“…•Economic, scientific and strategic challenges of the pharmaceutical industry are analyzed.•New approaches to increase the output of innovative medicine are…”
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Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η⁵-C₅H₅)(PPh₃)₂]⁺ as Promising Drugs Against Cisplatin -Resistant Cancer Cells and Human Mesenchymal Stem Cells by Gouveia, Marisol, Figueira, João, Jardim, Manuel G, Castro, Rita, Tomás, Helena, Rissanen, Kari, Rodrigues, João

“…Here and for the first time, we show that the organometallic compound [Ru(η⁵-C₅H₅)(PPh₃)₂Cl] (RuCp) has potential to be used as a metallodrug in anticancer…”
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Use of Half-Generation PAMAM Dendrimers (G0.5–G3.5) with Carboxylate End-Groups to Improve the DACHPtCl2 and 5-FU Efficacy as Anticancer Drugs by Camacho, Cláudia, Tomás, Helena, Rodrigues, João

“…The DACHPtCl2 compound (trans-(R,R)-1,2-diaminocyclohexanedichloroplatinum(II)) is a potent anticancer drug with a broad spectrum of activity and is less toxic…”
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PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia by Santos, Sofia D., Xavier, Miguel, Leite, Diana M., Moreira, Débora A., Custódio, Beatriz, Torrado, Marília, Castro, Rita, Leiro, Victoria, Rodrigues, João, Tomás, Helena, Pêgo, Ana P.

“…Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing…”
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Dendrimer-Assisted Formation of Fluorescent Nanogels for Drug Delivery and Intracellular Imaging by Gonçalves, Mara, Maciel, Dina, Capelo, Débora, Xiao, Shili, Sun, Wenjie, Shi, Xiangyang, Rodrigues, João, Tomás, Helena, Li, Yulin

“…Although, in general, nanogels present a good biocompatibility and are able to mimic biological tissues, their unstability and uncontrollable release…”
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RGD peptide-modified multifunctional dendrimer platform for drug encapsulation and targeted inhibition of cancer cells by He, Xuedan, Alves, Carla S., Oliveira, Nilsa, Rodrigues, João, Zhu, Jingyi, Bányai, István, Tomás, Helena, Shi, Xiangyang

“…•G5 dendrimers can be modified with RGD peptide via a PEG spacer.•DOX can be encapsulated within G5.NHAc-FI-PEG-RGD dendrimers to form stable…”
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An integrative approach based on GC–qMS and NMR metabolomics data as a comprehensive strategy to search potential breast cancer biomarkers by Silva, Catarina Luís, Perestrelo, Rosa, Capelinha, Filipa, Tomás, Helena, Câmara, José S.

“…Introduction Globally, breast cancer (BC) is leading at the top of women's diseases and, as a multifactorial disease, there is the need for the development of…”
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New anionic poly(alkylideneamine) dendrimers as microbicide agents against HIV-1 infection by Maciel, Dina, Guerrero-Beltrán, Carlos, Ceña-Diez, Rafael, Tomás, Helena, Muñoz-Fernández, M Ángeles, Rodrigues, João

“…Acquired immune deficiency syndrome (AIDS) due to human immunodeficiency virus type-1 (HIV-1) represents one of the most important sexually transmitted…”
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Breast Cancer Metabolomics: From Analytical Platforms to Multivariate Data Analysis. A Review by Silva, Catarina, Perestrelo, Rosa, Silva, Pedro, Tomás, Helena, Câmara, José S

“…Cancer is a major health issue worldwide for many years and has been increasing significantly. Among the different types of cancer, breast cancer (BC) remains…”
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Cytocompatible cellulose nanofibers from invasive plant species Agave americana L. and Ricinus communis L.: a renewable green source of highly crystalline nanocellulose by Evdokimova, Olga L., Alves, Carla S., Krsmanović Whiffen, Radenka M., Ortega, Zaida, Tomás, Helena, Rodrigues, João

“…In this study, the fibers of invasive species Agave americana L. and Ricinus communis L. were successfully used for the first time as new sources to produce…”
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