Search Results - "Tomé, Angelo R."

ATP as a multi-target danger signal in the brain by Rodrigues, Ricardo J, Tomé, Angelo R, Cunha, Rodrigo A

“…ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in…”
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Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease by Rial, Daniel, Castro, Adalberto A, Machado, Nuno, Garção, Pedro, Gonçalves, Francisco Q, Silva, Henrique B, Tomé, Angelo R, Köfalvi, Attila, Corti, Olga, Raisman-Vozari, Rita, Cunha, Rodrigo A, Prediger, Rui D

“…There is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the…”
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Adenosine receptor antagonists including caffeine alter fetal brain development in mice by Silva, Carla G, Métin, Christine, Fazeli, Walid, Machado, Nuno J, Darmopil, Sanja, Launay, Pierre-Serge, Ghestem, Antoine, Nesa, Marie-Pascale, Bassot, Emilie, Szabó, Eszter, Baqi, Younis, Müller, Christa E, Tomé, Angelo R, Ivanov, Anton, Isbrandt, Dirk, Zilberter, Yuri, Cunha, Rodrigo A, Esclapez, Monique, Bernard, Christophe

“…Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive…”
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Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models by Li, Wei, Silva, Henrique B, Real, Joana, Wang, Yu-Mei, Rial, Daniel, Li, Ping, Payen, Marie-Pierce, Zhou, Yuanguo, Muller, Christa E, Tomé, Angelo R, Cunha, Rodrigo A, Chen, Jiang-Fan

“…Abstract Cognitive impairments in Huntington's disease (HD) are attributed to a dysfunction of the cortico-striatal pathway and significantly affect the…”
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Adenosine A₂A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction by Rebola, Nelson, Simões, Ana Patrícia, Canas, Paula M, Tomé, Angelo R, Andrade, Geanne M, Barry, Claire E, Agostinho, Paula M, Lynch, Marina A, Cunha, Rodrigo A

“…J. Neurochem. (2011) 117, 100-111. ABSTRACT: The blockade of adenosine A₂A receptors (A2AR) affords a robust neuroprotection in different noxious brain…”
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Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress by Dias, Liliana, Lopes, Cátia R., Gonçalves, Francisco Q., Nunes, Ana, Pochmann, Daniela, Machado, Nuno J., Tomé, Angelo R., Agostinho, Paula, Cunha, Rodrigo A.

“…Depressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P 2X7…”
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Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer's Disease by Carvalho da Silva, António M, Lemos, Cristina, Silva, Henrique B, Ferreira, Ildete L, Tomé, Angelo R, Rego, A Cristina, Cunha, Rodrigo A

“…Alzheimer's disease (AD) is characterized by progressive memory deficits accompanied by synaptic and metabolic deficits, namely of mitochondrial function. AD…”
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Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation by Lopes, Cátia R., Gonçalves, Francisco Q., Olaio, Simão, Tomé, Angelo R., Cunha, Rodrigo A., Lopes, João Pedro

“…Adenosine operates a modulation system fine-tuning the efficiency of synaptic transmission and plasticity through A1 and A2A receptors (A1R, A2AR),…”
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Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway by Simões, Ana Patrícia, Duarte, João A, Agasse, Fabienne, Canas, Paula Margarida, Tomé, Angelo R, Agostinho, Paula, Cunha, Rodrigo A

“…Blockade of adenosine A(2A) receptors (A(2A)R) affords robust neuroprotection in a number of brain conditions, although the mechanisms are still unknown. A…”
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Nicotinic α7 receptor activation selectively potentiates the function of NMDA receptors in glutamatergic terminals of the nucleus accumbens by Zappettini, Stefania, Grilli, Massimo, Olivero, Guendalina, Chen, Jiayang, Padolecchia, Cristina, Pittaluga, Anna, Tomé, Angelo R, Cunha, Rodrigo A, Marchi, Mario

“…We here provide functional and immunocytochemical evidence supporting the co-localization and functional interaction between nicotinic acetylcholine receptors…”
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Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration by Gomes, Catarina V., Kaster, Manuella P., Tomé, Angelo R., Agostinho, Paula M., Cunha, Rodrigo A.

“…Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the central nervous system. Its neuromodulatory role relies on a balanced…”
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Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine by Gonçalves, Francisco Q., Lopes, João P., Silva, Henrique B., Lemos, Cristina, Silva, António C., Gonçalves, Nélio, Tomé, Ângelo R., Ferreira, Samira G., Canas, Paula M., Rial, Daniel, Agostinho, Paula, Cunha, Rodrigo A.

“…Adenosine A2A receptors (A2AR) overfunction causes synaptic and memory dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ1-42)-based model of…”
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Hippocampal long-term potentiation in adult mice after recovery from ketamine anesthesia by Ribeiro, Patrícia O., Silva, Henrique B., Tomé, Ângelo R., Cunha, Rodrigo A., Antunes, Luís M.

“…Ketamine is frequently used to induce analgesia or anesthesia in laboratory animals, but its effects on learning and memory are poorly characterized. Long-term…”
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Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress by Kaster, Manuella P, Machado, Nuno J, Silva, Henrique B, Nunes, Ana, Ardais, Ana Paula, Santana, Magda, Baqi, Younis, Müller, Christa E, Rodrigues, Ana Lúcia S, Porciúncula, Lisiane O, Chen, Jiang Fan, Tomé, Ângelo R, Agostinho, Paula, Canas, Paula M, Cunha, Rodrigo A

“…The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with depression and memory deterioration, and adenosine A2A receptor (A2AR)…”
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Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices by Fernandes, Mara Yone D., Dobrachinski, Fernando, Silva, Henrique B., Lopes, João Pedro, Gonçalves, Francisco Q., Soares, Felix A. A., Porciúncula, Lisiane O., Andrade, Geanne M., Cunha, Rodrigo A., Tomé, Angelo R.

“…The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford…”
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Convergence of adenosine and GABA signaling for synapse stabilization during development by Gomez-Castro, Ferran, Zappettini, Stefania, Pressey, Jessica C, Silva, Carla G, Russeau, Marion, Gervasi, Nicolas, Figueiredo, Marta, Montmasson, Claire, Renner, Marianne, Canas, Paula M, Gonçalves, Francisco Q, Alçada-Morais, Sofia, Szabó, Eszter, Rodrigues, Ricardo J, Agostinho, Paula, Tomé, Angelo R, Caillol, Ghislaine, Thoumine, Olivier, Nicol, Xavier, Leterrier, Christophe, Lujan, Rafael, Tyagarajan, Shiva K, Cunha, Rodrigo A, Esclapez, Monique, Bernard, Christophe, Lévi, Sabine

“…During development, neural circuit formation requires the stabilization of active γ-aminobutyric acid–mediated (GABAergic) synapses and the elimination of…”
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Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve by Mendes, Vera M, Coelho, Margarida, Tomé, Angelo R, Cunha, Rodrigo A, Manadas, Bruno

“…Caffeine is one of the most widely consumed psycho-stimulants. The study of the beneficial effects of caffeine consumption to decrease the risk of developing…”
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Use of knockout mice to explore CNS effects of adenosine by Lopes, Cátia R., Lourenço, Vanessa S., Tomé, Ângelo R., Cunha, Rodrigo A., Canas, Paula M.

“…[Display omitted] The initial exploration using pharmacological tools of the role of adenosine receptors in the brain, concluded that adenosine released as…”
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Caffeic acid recovers ischemia-induced synaptic dysfunction without direct effects on excitatory synaptic transmission and plasticity in mouse hippocampal slices by Fernandes, Mara Yone D., Lopes, João Pedro, Silva, Henrique B., Andrade, Geanne M., Cunha, Rodrigo A., Tomé, Angelo R.

“…•Caffeic acid does not affect excitatory synaptic transmission or plasticity.•Caffeic acid prevents ischemia-induced depression of synaptic function. Caffeic…”
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Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A2A receptor over‐activation in a rat model of Parkinson's disease by Carmo, Marta, Gonçalves, Francisco Q., Canas, Paula M., Oses, Jean‐Pierre, Fernandes, Francisco D., Duarte, Filipe V., Palmeira, Carlos M., Tomé, Angelo R., Agostinho, Paula, Andrade, Geanne M., Cunha, Rodrigo A.

“…Background and Purpose Parkinson's disease (PD) involves an initial loss of striatal dopamine terminals evolving into degeneration of dopamine neurons in…”
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