Search Results - "Tomás, J"

Engram cells retain memory under retrograde amnesia by Ryan, Tomás J., Roy, Dheeraj S., Pignatelli, Michele, Arons, Autumn, Tonegawa, Susumu

“…Memory consolidation is the process by which a newly formed and unstable memory transforms into a stable long-term memory. It is unknown whether the process of…”
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Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease by Roy, Dheeraj S., Arons, Autumn, Mitchell, Teryn I., Pignatelli, Michele, Ryan, Tomás J., Tonegawa, Susumu

“…Experiments in transgenic mouse models of early Alzheimer’s disease show that the amnesia seen at this stage of the disease is probably caused by a problem…”
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Creating a False Memory in the Hippocampus by Ramirez, Steve, Liu, Xu, Lin, Pei-Ann, Suh, Junghyup, Pignatelli, Michele, Redondo, Roger L., Ryan, Tomás J., Tonegawa, Susumu

“…Memories can be unreliable. We created a false memory in mice by optogenetically manipulating memory engram—bearing cells in the hippocampus. Dentate gyrus…”
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Forgetting as a form of adaptive engram cell plasticity by Ryan, Tomás J., Frankland, Paul W.

“…One leading hypothesis suggests that memories are stored in ensembles of neurons (or ‘engram cells’) and that successful recall involves reactivation of these…”
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Memory engram storage and retrieval by Tonegawa, Susumu, Pignatelli, Michele, Roy, Dheeraj S, Ryan, Tomás J

“…Highlights • We review the history of research into putative memory storage mechanisms. • We highlight recent advances catalyzed by memory engram labeling…”
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Engram Cell Excitability State Determines the Efficacy of Memory Retrieval by Pignatelli, Michele, Ryan, Tomás J., Roy, Dheeraj S., Lovett, Chanel, Smith, Lillian M., Muralidhar, Shruti, Tonegawa, Susumu

“…Animals need to optimize the efficacy of memory retrieval to adapt to environmental circumstances for survival. The recent development of memory engram…”
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What is memory? The present state of the engram by Poo, Mu-Ming, Pignatelli, Michele, Ryan, Tomás J, Tonegawa, Susumu, Bonhoeffer, Tobias, Martin, Kelsey C, Rudenko, Andrii, Tsai, Li-Huei, Tsien, Richard W, Fishell, Gord, Mullins, Caitlin, Gonçalves, J Tiago, Shtrahman, Matthew, Johnston, Stephen T, Gage, Fred H, Dan, Yang, Long, John, Buzsáki, György, Stevens, Charles

“…The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist…”
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Understanding the physical basis of memory: Molecular mechanisms of the engram by Ortega-de San Luis, Clara, Ryan, Tomás J.

“…Memory, defined as the storage and use of learned information in the brain, is necessary to modulate behavior and critical for animals to adapt to their…”
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Framing the future of neuroscience in a time of great upheaval: Introducing a series of essays by the scholars of the FENS‐Kavli network by Donato, Flavio, Ryan, Tomás J.

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Anatomic coracoclavicular ligament reconstruction with triple flip-buttons leads to good functional outcomes and low reduction loss: a case series by Raul Aguila, Gonzalo Gana, J Tomas Munoz, Diego Garcia de la Pastora, Andres Oyarzun, Gabriel Mansilla, Sebastian Coda, J Tomas Rojas

“…Background The management of acromioclavicular (AC) joint dislocation remains controversial. Recently, anatomic coracoclavicular (CC) fixation with a double…”
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Engram cell connectivity as a mechanism for information encoding and memory function by Ortega-de San Luis, Clara, Pezzoli, Maurizio, Urrieta, Esteban, Ryan, Tomás J

“…Information derived from experiences is incorporated into the brain as changes to ensembles of cells, termed engram cells, which allow memory storage and…”
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The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults by Martel, Marc-André, Ryan, Tomás J., Bell, Karen F.S., Fowler, Jill H., McMahon, Aoife, Al-Mubarak, Bashayer, Komiyama, Noboru H., Horsburgh, Karen, Kind, Peter C., Grant, Seth G.N., Wyllie, David J.A., Hardingham, Giles E.

“…It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca2+ influx is…”
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FENS‐Kavli Network of Excellence: Science needs strong European cohesion by O'Leary, Timothy, Hauser, Tobias U., Ryan, Tomás J., Rezaval, Carolina

“…Decades of scientific collaboration have brought innovation, prosperity and wide societal benefit to Europe. However, recent political events have impacted…”
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NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation by Frank, René A. W., Komiyama, Noboru H., Ryan, Tomás J., Zhu, Fei, O’Dell, Thomas J., Grant, Seth G. N.

“…How neuronal proteomes self-organize is poorly understood because of their inherent molecular and cellular complexity. Here, focusing on mammalian synapses we…”
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Thermal evolution of Andean iron oxide–apatite (IOA) deposits as revealed by magnetite thermometry by Palma, Gisella, Reich, Martin, Barra, Fernando, Ovalle, J. Tomás, del Real, Irene, Simon, Adam C.

“…Magnetite is the main constituent of iron oxide–apatite (IOA) deposits, which are a globally important source of Fe and other elements such as P and REE,…”
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Formation of massive iron deposits linked to explosive volcanic eruptions by Ovalle, J. Tomás, La Cruz, Nikita L., Reich, Martin, Barra, Fernando, Simon, Adam C., Konecke, Brian A., Rodriguez-Mustafa, María A., Deditius, Artur P., Childress, Tristan M., Morata, Diego

“…The genetic link between magmas and ore deposit formation is well documented by studies of fossil hydrothermal systems associated with magmatic intrusions at…”
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Biodiversity Conservation Requires Management of Feral Domestic Animals by Bonacic, Cristián, Almuna, Rocío, Ibarra, J. Tomás

“…The proliferation of feral domestic animals (FDAs) has been favored by human-induced landscape changes, a world population becoming increasingly urban, and by…”
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Glenoid component placement in reverse shoulder arthroplasty assisted with augmented reality through a head-mounted display leads to low deviation between planned and postoperative parameters by Rojas, J. Tomás, Jost, Bernhard, Zipeto, Claudio, Budassi, Piero, Zumstein, Matthias A.

“…BACKGROUNDNavigated augmented reality (AR) through a head-mounted display (HMD) may lead to accurate glenoid component placement in reverse shoulder…”
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Adaptive expression of engrams by retroactive interference by Autore, Livia, O’Leary, James D., Ortega-de San Luis, Clara, Ryan, Tomás J.

“…Long-term memories are stored as configurations of neuronal ensembles, termed engrams. Although investigation of engram cell properties and functionality in…”
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The origin and evolution of synapses by Grant, Seth G. N, Ryan, Tomás J

“…Key Points The molecular composition of the synapse has recently been proved to be useful for studying the evolution of the brain. Synapse proteomics data…”
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