Search Results - "Tomás, Ana M."

Development of an automated image analysis protocol for quantification of intracellular forms of Leishmania spp by Alves, Ana G. Gomes, Maia, André F., Cruz, Tânia, Castro, Helena, Tomás, Ana M.

“…Leishmania parasites cause a set of neglected tropical diseases with considerable public health impact, the leishmaniases, which are often fatal if left…”
Get full text

Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity by Castro, Helena, Teixeira, Filipa, Romao, Susana, Santos, Mariana, Cruz, Tânia, Flórido, Manuela, Appelberg, Rui, Oliveira, Pedro, Ferreira-da-Silva, Frederico, Tomás, Ana M

“…Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leishmania and related trypanosomatids, which lack catalase and…”
Get full text

Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems by Gaspar, Maria Manuela, PhD, Calado, Susana, Pereira, Joana, Ferronha, Helena, PhD, Correia, Ivone, Castro, Helena, PhD, Tomás, Ana M., PhD, Cruz, Maria Eugénia Meirinhos, PhD

“…Abstract Treatment of intracellular infections such as those caused by Mycobacterium spp. and Leishmania spp. is often hampered by limited access of drugs to…”
Get full text

Mechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper (Bothrops atrox) by Dematei, Anderson, Nunes, João B, Moreira, Daniel C, Jesus, Jéssica A, Laurenti, Márcia D, Mengarda, Ana C. A, Vieira, Maria Silva, do Amaral, Constança Pais, Domingues, Marco M, de Moraes, Josué, Passero, Luiz F. D, Brand, Guilherme, Bessa, Lucinda J, Wimmer, Reinhard, Kuckelhaus, Selma A. S, Tomás, Ana M, Santos, Nuno C, Plácido, Alexandra, Eaton, Peter, Leite, José Roberto S. A

“…Snake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are…”
Get full text

Mitochondrial redox metabolism in trypanosomatids is independent of tryparedoxin activity by Castro, Helena, Romao, Susana, Carvalho, Sandra, Teixeira, Filipa, Sousa, Carla, Tomás, Ana M

“…Tryparedoxins (TXNs) are oxidoreductases unique to trypanosomatids (including Leishmania and Trypanosoma parasites) that transfer reducing equivalents from…”
Get full text

Antileishmanial Activity of BNIPDaoct- and BNIPDanon-loaded Emulsomes on Leishmania infantum Parasites by Islek, Zeynep, Ucisik, Mehmet Hikmet, Keskin, Elif, Sucu, Bilgesu Onur, Gomes‐Alves, Ana G., Tomás, Ana M., Guzel, Mustafa, Sahin, Fikrettin

“…Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard,…”
Get full text

Catalysis and Structural Properties of Leishmania infantum Glyoxalase II:  Trypanothione Specificity and Phylogeny by Sousa Silva, Marta, Barata, Lídia, Ferreira, António E. N, Romão, Susana, Tomás, Ana M, Ponces Freire, Ana, Cordeiro, Carlos

“…The glyoxalase pathway catalyzes the formation of d-lactate from methylglyoxal, a toxic byproduct of glycolysis. In trypanosomatids, trypanothione replaces…”
Get full text

Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum by Teixeira, Filipa, Castro, Helena, Cruz, Tânia, Tse, Eric, Koldewey, Philipp, Southworth, Daniel R, Tomás, Ana M, Jakob, Ursula

“…Significance Peroxiredoxins (Prxs) are highly abundant proteins, which serve two seemingly mutually exclusive roles as peroxidases and molecular chaperones…”
Get full text

Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I by Duarte, Margarida, Ferreira, Cleide, Khandpur, Gurleen Kaur, Flohr, Tamara, Zimmermann, Jannik, Castro, Helena, Herrmann, Johannes M., Morgan, Bruce, Tomás, Ana M.

“…Type II NADH dehydrogenases (NDH2) are monotopic enzymes present in the external or internal face of the mitochondrial inner membrane that contribute to…”
Get full text

Redox metabolism in mitochondria of trypanosomatids by Tomás, Ana M, Castro, Helena

“…In the single mitochondrion of protozoan trypanosomatid parasites there are several sites for the generation and elimination of reactive oxygen species (ROS),…”
Get more information

Covalent Conjugation of Amphotericin B to Hyaluronic Acid: An Injectable Water-Soluble Conjugate with Reduced Toxicity and Anti-Leishmanial Potential by Silva-Carvalho, Ricardo, Leão, Teresa, Gama, Francisco M, Tomás, Ana M

“…Amphotericin B (AmB) is a highly hydrophobic drug with significant leishmanicidal activity whose use is limited by its poor water solubility and adverse…”
Get full text

The mitochondrial complex I of trypanosomatids - an overview of current knowledge by Duarte, Margarida, Tomás, Ana M.

“…The contribution of trypanosomatid mitochondrial complex I for energy transduction has long been debated. Herein, we summarize current knowledge on the…”
Get full text

Chaperone activation and client binding of a 2-cysteine peroxiredoxin by Teixeira, Filipa, Tse, Eric, Castro, Helena, Makepeace, Karl A. T., Meinen, Ben A., Borchers, Christoph H., Poole, Leslie B., Bardwell, James C., Tomás, Ana M., Southworth, Daniel R., Jakob, Ursula

“…Many 2-Cys-peroxiredoxins (2-Cys-Prxs) are dual-function proteins, either acting as peroxidases under non-stress conditions or as chaperones during stress. The…”
Get full text

Peroxidases of trypanosomatids by Castro, Helena, Tomás, Ana M

“…This article provides an overview about the recent advances in the dissection of the peroxide metabolism of Trypanosomatidae. This family of protozoan…”
Get more information

In Silico Discovery of a Substituted 6-Methoxy-quinalidine with Leishmanicidal Activity in Leishmania infantum by Stevanović, Strahinja, Perdih, Andrej, Senćanski, Milan, Glišić, Sanja, Duarte, Margarida, Tomás, Ana M, Sena, Filipa V, Sousa, Filipe M, Pereira, Manuela M, Solmajer, Tom

“…There is an urgent need for the discovery of new antileishmanial drugs with a new mechanism of action. Type 2 NADH dehydrogenase from ( NDH2) is an enzyme of…”
Get full text

Biological Evaluation and Mechanistic Studies of Quinolin-(1 H )-Imines as a New Chemotype against Leishmaniasis by Gomes-Alves, Ana Georgina, Duarte, Margarida, Cruz, Tânia, Castro, Helena, Lopes, Francisca, Moreira, Rui, Ressurreição, Ana S, Tomás, Ana M

“…Leishmaniasis is one of the most challenging neglected tropical diseases and remains a global threat to public health. Currently available therapies for…”
Get full text

The cytosolic tryparedoxin of Leishmania infantum is essential for parasite survival by Romao, Susana, Castro, Helena, Sousa, Carla, Carvalho, Sandra, Tomás, Ana M.

“…Leishmania infantum cytosolic tryparedoxin ( LiTXN1) can be regarded as a potential candidate for drug targeting. This redox active molecule, which belongs to…”
Get full text

Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli by Marani, Mariela M., Perez, Luis O., de Araujo, Alyne Rodrigues, Plácido, Alexandra, Sousa, Carla F., Quelemes, Patrick Veras, Oliveira, Mayara, Gomes-Alves, Ana G., Pueta, Mariana, Gameiro, Paula, Tomás, Ana M., Delerue-Matos, Cristina, Eaton, Peter, Camperi, Silvia A., Basso, Néstor G., de Souza de Almeida Leite, Jose Roberto

“…Patagonia's biodiversity has been explored from many points of view, however, skin secretions of native amphibians have not been evaluated for antimicrobial…”
Get full text

Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum by Sousa, André F., Gomes-Alves, Ana G., Benítez, Diego, Comini, Marcelo A., Flohé, Leopold, Jaeger, Timo, Passos, Joana, Stuhlmann, Friedrich, Tomás, Ana M., Castro, Helena

“…Trypanothione is a unique and essential redox metabolite of trypanosomatid parasites, the biosynthetic pathway of which is regarded as a promising target for…”
Get full text

Structure-Activity Relationship Studies of 9-Alkylamino-1,2,3,4-tetrahydroacridines against Leishmania ( Leishmania ) infantum Promastigotes by Silva, Carlos F M, Leão, Teresa, Dias, Filipa, Tomás, Ana M, Pinto, Diana C G A, Oliveira, Eduardo F T, Oliveira, Ana, Fernandes, Pedro A, Silva, Artur M S

“…Leishmaniasis is one of the most neglected diseases in modern times, mainly affecting people from developing countries of the tropics, subtropics and the…”
Get full text