Search Results - "Tolwinski, Nicholas"

WNT Signaling in Disease by Ng, Li Fang, Kaur, Prameet, Bunnag, Nawat, Suresh, Jahnavi, Sung, Isabelle Chiao Han, Tan, Qian Hui, Gruber, Jan, Tolwinski, Nicholas S

“…Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered…”
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Introduction: Drosophila-A Model System for Developmental Biology by Tolwinski, Nicholas S

“…Drosophila melanogaster, known colloquially as the fruit fly, remains one of the most commonly used model organisms for biomedical science.[...]…”
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Using Optogenetics to Model Cellular Effects of Alzheimer's Disease by Tiwari, Prabhat, Tolwinski, Nicholas S

“…Across the world a dementia case is diagnosed every three seconds. Alzheimer's disease (AD) causes 50-60% of these cases. The most prominent theory for AD…”
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Developmental Drift and the Role of Wnt Signaling in Aging by Gruber, Jan, Yee, Zhuangli, Tolwinski, Nicholas S

“…Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases…”
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Wnt signaling pathways meet Rho GTPases by Schlessinger, Karni, Hall, Alan, Tolwinski, Nicholas

“…Wnt ligands and their receptors orchestrate many essential cellular and physiological processes. During development they control differentiation,…”
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The many roles of PTK7: A versatile regulator of cell–cell communication by Peradziryi, Hanna, Tolwinski, Nicholas S., Borchers, Annette

“…► Wnt co-receptors decide Wnt signaling outcome. ► Wnt co-receptor PTK7 regulates planar cell polarity. ► Wnt co-receptor PTK7 turns off canonical Wnt…”
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Drosophila -A Model System for Developmental Biology by Tolwinski, Nicholas S

“…In this Special Issue, titled " -A Model System for Developmental Biology", we present a series of articles and reviews looking at the diverse ways that…”
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Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling by Admasu, Tesfahun Dessale, Chaithanya Batchu, Krishna, Barardo, Diogo, Ng, Li Fang, Lam, Vanessa Yuk Man, Xiao, Linfan, Cazenave-Gassiot, Amaury, Wenk, Markus R., Tolwinski, Nicholas S., Gruber, Jan

“…There is growing interest in pharmacological interventions directly targeting the aging process. Pharmacological interventions against aging should be…”
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Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis by Kaur, Prameet, Saunders, Timothy E., Tolwinski, Nicholas S.

“…Optogenetics allows precise, fast and reversible intervention in biological processes. Light-sheet microscopy allows observation of the full course of…”
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Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo by Huang, Anqi, Amourda, Christopher, Zhang, Shaobo, Tolwinski, Nicholas S, Saunders, Timothy E

“…Morphogen gradients provide essential spatial information during development. Not only the local concentration but also duration of morphogen exposure is…”
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Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer by Dunn, Norris Ray, Tolwinski, Nicholas S

“…Human development uses a remarkably small number of signal transduction pathways to organize vastly complicated tissues. These pathways are commonly associated…”
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The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing by Hong, Shin Yee, Ng, Li Theng, Ng, Li Fang, Inoue, Takao, Tolwinski, Nicholas S, Hagen, Thilo, Gruber, Jan

“…In recent years, various large-scale proteomic studies have demonstrated that mitochondrial proteins are highly acylated, most commonly by addition of acetyl…”
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MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation by Tomaz, Lucian B, Liu, Bernard A, Meroshini M, Ong, Sheena L M, Tan, Ee Kim, Tolwinski, Nicholas S, Williams, Christopher S, Gingras, Anne-Claude, Leushacke, Marc, Dunn, N Ray

“…The gene mutated in colorectal cancer (MCC) encodes a coiled-coil protein implicated, as its name suggests, in the pathogenesis of hereditary human colon…”
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Combining stem cell rejuvenation and senescence targeting to synergistically extend lifespan by Kaur, Prameet, Otgonbaatar, Agimaa, Ramamoorthy, Anupriya, Chua, Ellora Hui Zhen, Harmston, Nathan, Gruber, Jan, Tolwinski, Nicholas S

“…Why biological age is a major risk factor for many of the most important human diseases remains mysterious. We know that as organisms age, stem cell pools are…”
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An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis by Bunnag, Nawat, Tan, Qian Hui, Kaur, Prameet, Ramamoorthy, Anupriya, Sung, Isabelle Chiao Han, Lusk, Jay, Tolwinski, Nicholas S.

“…Homeostasis in adult organs involves replacement of cells from a stem cell pool maintained in specialized niches regulated by extracellular signals. This…”
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Wnt pathway activation by ADP-ribosylation by Yang, Eungi, Tacchelly-Benites, Ofelia, Wang, Zhenghan, Randall, Michael P., Tian, Ai, Benchabane, Hassina, Freemantle, Sarah, Pikielny, Claudio, Tolwinski, Nicholas S., Lee, Ethan, Ahmed, Yashi

“…Wnt/β-catenin signalling directs fundamental processes during metazoan development and can be aberrantly activated in cancer. Wnt stimulation induces the…”
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Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta by Teo, Emelyne, Ravi, Sudharshan, Barardo, Diogo, Kim, Hyung-Seok, Fong, Sheng, Cazenave-Gassiot, Amaury, Tan, Tsze Yin, Ching, Jianhong, Kovalik, Jean-Paul, Wenk, Markus R, Gunawan, Rudiyanto, Moore, Philip K, Halliwell, Barry, Tolwinski, Nicholas, Gruber, Jan

“…Alzheimer's disease (AD) is the most common neurodegenerative disease affecting the elderly worldwide. Mitochondrial dysfunction has been proposed as a key…”
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Shared signaling pathways in Alzheimer’s and metabolic disease may point to new treatment approaches by Suresh, Jahnavi, Khor, Ing Wei, Kaur, Prameet, Heng, Hui Li, Torta, Federico, Dawe, Gavin S., Tai, E Shyong, Tolwinski, Nicholas S.

“…This review focuses recent findings that relate metabolic disease to Alzheimer’s disease especially considering the similarities between neurodegeneration and…”
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PTK7/Otk interacts with Wnts and inhibits canonical Wnt signalling by Peradziryi, Hanna, Kaplan, Nicole A, Podleschny, Martina, Liu, Xiaoping, Wehner, Peter, Borchers, Annette, Tolwinski, Nicholas S

“…Wnt signalling is an evolutionarily conserved pathway that directs cell‐fate determination and morphogenesis during metazoan development. Wnt ligands are…”
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Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration by Lim, Chu Hsien, Kaur, Prameet, Teo, Emelyne, Lam, Vanessa Yuk Man, Zhu, Fangchen, Kibat, Caroline, Gruber, Jan, Mathuru, Ajay S, Tolwinski, Nicholas S

“…The brains of Alzheimer's disease patients show a decrease in brain mass and a preponderance of extracellular Amyloid-β plaques. These plaques are formed by…”
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