Search Results - "Tolosa, Eduardo"

Idiopathic rapid eye movement sleep behaviour disorder: diagnosis, management, and the need for neuroprotective interventions by Iranzo, Alex, Dr, Santamaria, Joan, MD, Tolosa, Eduardo, MD

“…Summary Idiopathic rapid eye movement (REM) sleep behaviour disorder (IRBD) manifests as unpleasant dreams and vigorous behaviours during REM sleep that can…”
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The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy by Wenning, Gregor K., Stankovic, Iva, Vignatelli, Luca, Fanciulli, Alessandra, Calandra‐Buonaura, Giovanna, Seppi, Klaus, Palma, Jose‐Alberto, Meissner, Wassilios G., Krismer, Florian, Berg, Daniela, Cortelli, Pietro, Freeman, Roy, Halliday, Glenda, Höglinger, Günter, Lang, Anthony, Ling, Helen, Litvan, Irene, Low, Phillip, Miki, Yasuo, Panicker, Jalesh, Pellecchia, Maria Teresa, Quinn, Niall, Sakakibara, Ryuji, Stamelou, Maria, Tolosa, Eduardo, Tsuji, Shoji, Warner, Tom, Poewe, Werner, Kaufmann, Horacio

“…ABSTRACT Background The second consensus criteria for the diagnosis of multiple system atrophy (MSA) are widely recognized as the reference standard for…”
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Levodopa in the treatment of Parkinson's disease: current status and new developments by Salat, David, Tolosa, Eduardo

“…Levodopa, a dopamine precursor, is an effective and well-tolerated dopamine replacement agent used to treat Parkinson's disease (PD). Oral levodopa has been…”
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When does Parkinson's disease begin? by Gaig, Carles, Tolosa, Eduardo

“…Pathological and neuroimaging studies have shown that in Parkinson's disease (PD) there is a “subclinical” or “premotor” period during which dopaminergic…”
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Trial of Cinpanemab in Early Parkinson’s Disease by Lang, Anthony E., Siderowf, Andrew D., Macklin, Eric A., Poewe, Werner, Brooks, David J., Fernandez, Hubert H., Rascol, Olivier, Giladi, Nir, Stocchi, Fabrizio, Tanner, Caroline M., Postuma, Ronald B., Simon, David K., Tolosa, Eduardo, Mollenhauer, Brit, Cedarbaum, Jesse M., Fraser, Kyle, Xiao, James, Evans, Karleyton C., Graham, Danielle L., Sapir, Inbal, Inra, Jennifer, Hutchison, R. Matthew, Yang, Minhua, Fox, Tara, Budd Haeberlein, Samantha, Dam, Tien

“…In a phase 2 trial in early Parkinson’s disease, treatment with cinpanemab, a monoclonal antibody to α-synuclein, did not affect clinical or imaging…”
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Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders by Gelpi, Ellen, Navarro-Otano, Judith, Tolosa, Eduardo, Gaig, Carles, Compta, Yaroslau, Rey, María Jesús, Martí, Maria José, Hernández, Isabel, Valldeoriola, Francesc, Reñé, Ramon, Ribalta, Teresa

“…ABSTRACT Lewy body (LB) diseases are characterized by alpha‐synuclein (AS) aggregates in the central nervous system (CNS). Involvement of the peripheral…”
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Challenges of modifying disease progression in prediagnostic Parkinson's disease by Salat, David, MD, Noyce, Alastair J, MRCP, Schrag, Anette, Prof, Tolosa, Eduardo, Prof

“…Summary Neurodegeneration in Parkinson's disease starts years before a clinical diagnosis can be reliably made. The prediagnostic phase of the disease offers a…”
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Opicapone for the treatment of Parkinson's disease: A review of a new licensed medicine by Fabbri, Margherita, Ferreira, Joaquim J., Lees, Andrew, Stocchi, Fabrizio, Poewe, Werner, Tolosa, Eduardo, Rascol, Olivier

“…Catechol‐O‐methyl transferase inhibitors are currently used as first‐line add‐on therapy to levodopa for the treatment of end‐of‐dose motor fluctuations in…”
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Functional brain networks and cognitive deficits in Parkinson's disease by Baggio, Hugo-Cesar, Sala-Llonch, Roser, Segura, Bàrbara, Marti, Maria-José, Valldeoriola, Francesc, Compta, Yaroslau, Tolosa, Eduardo, Junqué, Carme

“…Graph‐theoretical analyses of functional networks obtained with resting‐state functional magnetic resonance imaging (fMRI) have recently proven to be a useful…”
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Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease by di Domenico, Angelique, Carola, Giulia, Calatayud, Carles, Pons-Espinal, Meritxell, Muñoz, Juan Pablo, Richaud-Patin, Yvonne, Fernandez-Carasa, Irene, Gut, Marta, Faella, Armida, Parameswaran, Janani, Soriano, Jordi, Ferrer, Isidro, Tolosa, Eduardo, Zorzano, Antonio, Cuervo, Ana Maria, Raya, Angel, Consiglio, Antonella

“…Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A…”
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The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PD Study) by Pont-Sunyer, Claustre, Hotter, Anna, Gaig, Carles, Seppi, Klaus, Compta, Yaroslau, Katzenschlager, Regina, Mas, Natalia, Hofeneder, Dominik, Brücke, Thomas, Bayés, Angels, Wenzel, Karoline, Infante, Jon, Zach, Heidemarie, Pirker, Walter, Posada, Ignacio J., Álvarez, Ramiro, Ispierto, Lourdes, De Fàbregues, Oriol, Callén, Antoni, Palasí, Antoni, Aguilar, Miquel, Martí, Maria José, Valldeoriola, Francesc, Salamero, Manel, Poewe, Werner, Tolosa, Eduardo

“…ABSTRACT Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor symptoms. Relationship between premotor symptoms onset and motor…”
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The phenotypic spectrum of progressive supranuclear palsy: A retrospective multicenter study of 100 definite cases by Respondek, Gesine, Stamelou, Maria, Kurz, Carolin, Ferguson, Leslie W., Rajput, Alexander, Chiu, Wan Zheng, van Swieten, John C., Troakes, Claire, al Sarraj, Safa, Gelpi, Ellen, Gaig, Carles, Tolosa, Eduardo, Oertel, Wolfgang H., Giese, Armin, Roeber, Sigrun, Arzberger, Thomas, Wagenpfeil, Stefan, Höglinger, Günter U.

“…The phenotypic variability of progressive supranuclear palsy (PSP) may account for its frequent misdiagnosis, in particular in early stages of the disease…”
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Criteria for the diagnosis of corticobasal degeneration by ARMSTRONG, Melissa J, LITVAN, Irene, JOSEPHS, Keith A, KERTESZ, Andrew, LEE, Suzee E, MILLER, Bruce L, REICH, Stephen G, RILEY, David E, TOLOSA, Eduardo, TROSTER, Alexander I, VIDAILHET, Marie, WEINER, William J, LANG, Anthony E, BAK, Thomas H, BHATIA, Kailash P, BORRONI, Barbara, BOXER, Adam L, DICKSON, Dennis W, GROSSMAN, Murray, HALLETT, Mark

“…Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this…”
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Four pioneers of L-dopa treatment: Arvid Carlsson, Oleh Hornykiewicz, George Cotzias, and Melvin Yahr by Lees, Andrew J., Tolosa, Eduardo, Olanow, C. Warren

“…ABSTRACT Four individuals stand out as pioneers of the early work that led to levodopa becoming a revolutionary new treatment for Parkinson's disease: Arvid…”
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Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD by Mahlknecht, Philipp, Iranzo, Alex, Högl, Birgit, Frauscher, Birgit, Müller, Christoph, Santamaría, Joan, Tolosa, Eduardo, Serradell, Monica, Mitterling, Thomas, Gschliesser, Viola, Goebel, Georg, Brugger, Florian, Scherfler, Christoph, Poewe, Werner, Seppi, Klaus

“…OBJECTIVE:The aim of the present study was to determine the predictive value of olfactory dysfunction for the early development of a synuclein-mediated…”
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Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study by Vilas, Dolores, MD, Iranzo, Alex, MD, Tolosa, Eduardo, Prof, Aldecoa, Iban, MD, Berenguer, Joan, MD, Vilaseca, Isabel, MD, Martí, Carles, MD, Serradell, Mónica, BSc, Lomeña, Francisco, MD, Alós, Llucia, MD, Gaig, Carles, MD, Santamaria, Joan, MD, Gelpi, Ellen, MD

“…Summary Background The histological feature of Parkinson's disease is the presence of intraneuronal aggregates of phosphorylated α-synuclein (αSyn). In…”
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Pramipexole for the treatment of depressive symptoms in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled trial by Barone, Paolo, Prof, Poewe, Werner, Prof, Albrecht, Stefan, MD, Debieuvre, Catherine, PharmD, Massey, Dan, MSc, Rascol, Olivier, Prof, Tolosa, Eduardo, Prof, Weintraub, Daniel, Prof

“…Summary Background Depression is common in patients with Parkinson's disease, but evidence on the efficacy of antidepressants in this population is lacking…”
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Memantine for patients with Parkinson's disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial by Emre, Murat, Prof, Tsolaki, Magda, MD, Bonuccelli, Ubaldo, Prof, Destée, Alain, Prof, Tolosa, Eduardo, Prof, Kutzelnigg, Alexandra, MD, Ceballos-Baumann, Andrés, Prof, Zdravkovic, Slobodan, PhD, Bladström, Anna, MSc, Jones, Roy, Prof

“…Summary Background Previous studies have suggested that patients with Lewy-body-related dementias might benefit from treatment with the N-methyl D-aspartate…”
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Diagnosis and the premotor phase of Parkinson disease by Tolosa, Eduardo, Gaig, Carles, Santamaría, Joan, Compta, Yaroslau

“…Clinical, neuroimaging, and pathologic studies have provided data suggesting that a variety of nonmotor symptoms can precede the classic motor features of…”
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Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non‐Ashkenazi Jewish ancestry by Lee, Annie J., Wang, Yuanjia, Alcalay, Roy N., Mejia‐Santana, Helen, Saunders‐Pullman, Rachel, Bressman, Susan, Corvol, Jean‐Christophe, Brice, Alexis, Lesage, Suzanne, Mangone, Graziella, Tolosa, Eduardo, Pont‐Sunyer, Claustre, Vilas, Dolores, Schüle, Birgitt, Kausar, Farah, Foroud, Tatiana, Berg, Daniela, Brockmann, Kathrin, Goldwurm, Stefano, Siri, Chiara, Asselta, Rosanna, Ruiz‐Martinez, Javier, Mondragón, Elisabet, Marras, Connie, Ghate, Taneera, Giladi, Nir, Mirelman, Anat, Marder, Karen

“…ABSTRACT Background Penetrance estimates of the leucine‐rich repeat kinase 2 (LRRK2) p.G2019S mutation for PD vary widely (24%‐100%). The p.G2019S penetrance…”
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