Search Results - "Tolnay, Markus"

The propagation of prion-like protein inclusions in neurodegenerative diseases by Goedert, Michel, Clavaguera, Florence, Tolnay, Markus

“…The most common neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterized by the misfolding of a small number of…”
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Two distinct immunopathological profiles in autopsy lungs of COVID-19 by Nienhold, Ronny, Ciani, Yari, Koelzer, Viktor H., Tzankov, Alexandar, Haslbauer, Jasmin D., Menter, Thomas, Schwab, Nathalie, Henkel, Maurice, Frank, Angela, Zsikla, Veronika, Willi, Niels, Kempf, Werner, Hoyler, Thomas, Barbareschi, Mattia, Moch, Holger, Tolnay, Markus, Cathomas, Gieri, Demichelis, Francesca, Junt, Tobias, Mertz, Kirsten D.

“…Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a…”
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Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy by SCHAEFFER, Veronique, LAVENIR, Isabelle, OZCELIK, Sefika, TOLNAY, Markus, WINKLER, David T, GOEDERT, Michel

“…The accumulation of insoluble proteins is a pathological hallmark of several neurodegenerative disorders. Tauopathies are caused by the dysfunction and…”
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Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology by Deigendesch, Nikolaus, Sironi, Lara, Kutza, Michael, Wischnewski, Sven, Fuchs, Vidmante, Hench, Jürgen, Frank, Angela, Nienhold, Ronny, Mertz, Kirsten D., Cathomas, Gieri, Matter, Matthias S., Siegemund, Martin, Tolnay, Markus, Schirmer, Lucas, Pröbstel, Anne-Katrin, Tzankov, Alexandar, Frank, Stephan

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Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies by Goedert, Michel, Falcon, Ben, Clavaguera, Florence, Tolnay, Markus

“…Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, are characterized by the abnormal aggregation of a small number of…”
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Transmission and spreading of tauopathy in transgenic mouse brain by Crowther, R. Anthony, Clavaguera, Florence, Abramowski, Dorothee, Goedert, Michel, Bolmont, Tristan, Probst, Alphonse, Tolnay, Markus, Fraser, Graham, Staufenbiel, Matthias, Stalder, Anna K, Jucker, Mathias, Beibel, Martin, Frank, Stephan

“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Invited review: Prion-like transmission and spreading of tau pathology by Clavaguera, Florence, Hench, Jürgen, Goedert, Michel, Tolnay, Markus

“…Filaments made of hyperphosphorylated tau protein are encountered in a number of neurodegenerative diseases referred to as ‘tauopathies’. In the most prevalent…”
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Tumor mutational burden assessed by targeted NGS predicts clinical benefit from immune checkpoint inhibitors in non‐small cell lung cancer by Alborelli, Ilaria, Leonards, Katharina, Rothschild, Sacha I, Leuenberger, Laura P, Savic Prince, Spasenija, Mertz, Kirsten D, Poechtrager, Severin, Buess, Martin, Zippelius, Alfred, Läubli, Heinz, Haegele, Jasmin, Tolnay, Markus, Bubendorf, Lukas, Quagliata, Luca, Jermann, Philip

“…In non‐small cell lung cancer (NSCLC), immune checkpoint inhibitors (ICIs) significantly improve overall survival (OS). Tumor mutational burden (TMB) has…”
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"Prion-Like" Templated Misfolding in Tauopathies by Clavaguera, Florence, Lavenir, Isabelle, Falcon, Ben, Frank, Stephan, Goedert, Michel, Tolnay, Markus

“…The soluble microtubule‐associated protein tau forms hyperphosphorylated, insoluble and filamentous inclusions in a number of neurodegenerative diseases…”
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Liquid Biopsy in Clinical Management of Breast, Lung, and Colorectal Cancer by Hench, Ivana Bratić, Hench, Jürgen, Tolnay, Markus

“…Examination of tumor molecular characteristics by liquid biopsy is likely to greatly influence personalized cancer patient management. Analysis of circulating…”
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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice by Ozcelik, Sefika, Fraser, Graham, Castets, Perrine, Schaeffer, Véronique, Skachokova, Zhiva, Breu, Karin, Clavaguera, Florence, Sinnreich, Michael, Kappos, Ludwig, Goedert, Michel, Tolnay, Markus, Winkler, David Theo

“…Altered autophagy contributes to the pathogenesis of Alzheimer's disease and other tauopathies, for which curative treatment options are still lacking. We have…”
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Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice by Clavaguera, Florence, Hench, Jürgen, Lavenir, Isabelle, Schweighauser, Gabriel, Frank, Stephan, Goedert, Michel, Tolnay, Markus

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Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21 by Restelli, Lisa Michelle, Oettinghaus, Björn, Halliday, Mark, Agca, Cavit, Licci, Maria, Sironi, Lara, Savoia, Claudia, Hench, Jürgen, Tolnay, Markus, Neutzner, Albert, Schmidt, Alexander, Eckert, Anne, Mallucci, Giovanna, Scorrano, Luca, Frank, Stephan

“…Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not…”
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DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress by Oettinghaus, Björn, D'Alonzo, Donato, Barbieri, Elisa, Restelli, Lisa Michelle, Savoia, Claudia, Licci, Maria, Tolnay, Markus, Frank, Stephan, Scorrano, Luca

“…During apoptosis mitochondria undergo cristae remodeling and fragmentation, but how the latter relates to outer membrane permeabilization and downstream…”
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The Prion-Like Behavior of Assembled Tau in Transgenic Mice by Clavaguera, Florence, Tolnay, Markus, Goedert, Michel

“…Tauopathies constitute neurodegenerative diseases that are characterized by the intracellular deposition of filaments made of hyperphosphorylated tau protein…”
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Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease by Sironi, Lara, Restelli, Lisa Michelle, Tolnay, Markus, Neutzner, Albert, Frank, Stephan

“…The pathogenesis of Parkinson's disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial…”
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Lethal recessive myelin toxicity of prion protein lacking its central domain by Baumann, Frank, Tolnay, Markus, Brabeck, Christine, Pahnke, Jens, Kloz, Ulrich, Niemann, Hartmut H, Heikenwalder, Mathias, Rülicke, Thomas, Bürkle, Alexander, Aguzzi, Adriano

“…PrPC‐deficient mice expressing prion protein variants with large amino‐proximal deletions (termed PrPΔF) suffer from neurodegeneration, which is rescued by…”
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Argyrophilic grain disease: A late-onset dementia with distinctive features among tauopathies by Tolnay, Markus, Clavaguera, Florence

“…Argyrophilic grain disease (AgD) is a late‐onset dementia morphologically characterized by the presence of abundant spindle‐shaped argyrophilic grains (ArG) in…”
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EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics by Hench, Jürgen, Hultschig, Claus, Brugger, Jon, Mariani, Luigi, Guzman, Raphael, Soleman, Jehuda, Leu, Severina, Benton, Miles, Stec, Irenäus Maria, Hench, Ivana Bratic, Hoffmann, Per, Harter, Patrick, Weber, Katharina J, Albers, Anne, Thomas, Christian, Hasselblatt, Martin, Schüller, Ulrich, Restelli, Lisa, Capper, David, Hewer, Ekkehard, Diebold, Joachim, Kolenc, Danijela, Schneider, Ulf C, Rushing, Elisabeth, Della Monica, Rosa, Chiariotti, Lorenzo, Sill, Martin, Schrimpf, Daniel, von Deimling, Andreas, Sahm, Felix, Kölsche, Christian, Tolnay, Markus, Frank, Stephan

“…DNA methylation analysis based on supervised machine learning algorithms with static reference data, allowing diagnostic tumour typing with unprecedented…”
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