Search Results - "Tolnay, Máté"

Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA by Agarwal, Stuti, Kraus, Zachary, Dement-Brown, Jessica, Alabi, Oyeleye, Starost, Kyle, Tolnay, Mate

“…Human Fc receptor-like 3 (FCRL3) is an orphan receptor expressed by lymphocytes, including regulatory T cells. FCRL3 is implicated in several autoimmune…”
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Fc receptor-like 4 and 5 define human atypical memory B cells by Li, Huifang, Dement-Brown, Jessica, Liao, Pei-Jyun, Mazo, Ilya, Mills, Frederick, Kraus, Zachary, Fitzsimmons, Sean, Tolnay, Mate

“…Abstract Atypical memory B cells accumulate in chronic infections and autoimmune conditions, and commonly express FCRL4 and FCRL5, respective IgA and IgG…”
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CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity by Franco, Andrea, Kraus, Zachary, Li, Huifang, Seibert, Naomi, Dement-Brown, Jessica, Tolnay, Mate

“…The B-cell response to antigen is critically regulated by co-receptors. CD21 (complement receptor 2) amplifies the response to antigen linked to its ligands,…”
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Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors by Franco, Andrea, Damdinsuren, Bazarragchaa, Ise, Tomoko, Dement-Brown, Jessica, Li, Huifang, Nagata, Satoshi, Tolnay, Mate

“…Fc receptor-like (FCRL) 5 regulates B cell Ag receptor signaling and has been reported to bind aggregated IgG. Using surface plasmon resonance, we analyzed the…”
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Fc receptor-like 5 promotes B cell proliferation and drives the development of cells displaying switched isotypes by Dement‐Brown, Jessica, Newton, Christopher S., Ise, Tomoko, Damdinsuren, Bazarragchaa, Nagata, Satoshi, Tolnay, Mate

“…FCRL5 stimulation, together with defined co‐stimuli, modulates the functional responses of human naive B cells. The biological roles of B cell membrane…”
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Lymphocytes sense antibodies through human FCRL proteins: Emerging roles in mucosal immunity by Tolnay, Mate

“…Members of the Fc receptor‐like (FCRL) family modulate B and T cell responses, yet their functional roles remain enigmatic. Nevertheless, FCRL3 promoter…”
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FCRL4 and FCRL5 expression distinguishes three human memory B cell subsets in tonsils by Li, Huifang, Tolnay, Mate

“…Abstract FCRL4 and FCRL5 are two members of the human Fc receptor like family with the capacity to regulate antigen receptor signaling. FCRL4 was shown to bind…”
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Fc Receptor-like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue-like Memory B Cells by Li, Huifang, Borrego, Francisco, Nagata, Satoshi, Tolnay, Mate

“…Fc receptor-like (FCRL) 5 is a novel IgG binding protein expressed on B cells, with the capacity to regulate Ag receptor signaling. We assessed FCRL5…”
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Antibody mediated lysis of hapten-conjugated target cells by macrophages and by complement: the influence of IgG subclass, antibody and hapten density by Miklós, K, Tolnay, M, Bazin, H, Medgyesi, G A

“…Lysis of 51Cr-labeled TNP-SRBC sensitised by rat IgG1 or IgG2a type antibodies by homologous, paraffin oil-elicited peritoneal macrophages (ADCC) or by…”
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Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants by Alabi, Oyeleye, Dement-Brown, Jessica, Tolnay, Mate

“…•FCRL5, unlike Fc-receptors, discriminate IgG2 disulfide isoforms.•FCRL5, unlike Fc-receptors, discriminate IgG2 charge variants.•IgG2 disulfide isoforms and…”
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FCRL3 modulates the function of human thymic regulatory T cells by Kraus, Zachary J, Agarwal, Stuti, Dement-Brown, Jessica, Tolnay, Mate

“…Abstract Peripheral tolerance is achieved as the result of a delicate balance between inflammatory and tolerogenic signals. Regulatory T cells (Treg) are at…”
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The novel IgG-receptor FCRL5 is able to distinguish IgG2 disulfide isomers and displays increased affinity for heat-stressed IgG2 by Alabi, Oyeleye A, Dement-Brown, Jessica, Tolnay, Mate

“…Abstract Human Fc receptor-like 5 (FCRL5) is a novel IgG receptor that senses the whole IgG molecule, including the Fc and F(ab′)2 portions. Using surface…”
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B cell receptor induced Fc receptor-like 5 expression is mediated by multiple signaling pathways converging on NF-κB and NFAT by Damdinsuren, Bazarragchaa, Dement-Brown, Jessica, Li, Huifang, Tolnay, Mate

“…•Human FCRL5 is induced upon B cell antigen receptor stimulation.•FCRL5 induction is delayed and requires sustained stimulation.•Induced FCRL5 expression is…”
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U.S. Food and Drug Administration Approval: Obinutuzumab in Combination with Chlorambucil for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia by LEE, Hyon-Zu, MILLER, Barry W, KO, Chia-Wen, LEI NIE, SHAPIRO, Marjorie, TOLNAY, Mate, KANE, Robert C, KAMINSKAS, Edvardas, JUSTICE, Robert, FARRELL, Ann T, PAZDUR, Richard, KWITKOWSKI, Virginia E, RICCI, Stacey, DELVALLE, Pedro, SABER, Haleh, GRILLO, Joseph, BULLOCK, Julie, FLORIAN, Jeffry, MEHROTRA, Nitin

“…On November 1, 2013, the U.S. Food and Drug Administration (FDA) approved obinutuzumab (GAZYVA; Genentech, Inc.), a CD20-directed cytolytic antibody, for use…”
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Human Fc receptor-like 5 interacts with key signaling proteins in B cells (P1116) by Franco, Andrea, Damdinsuren, Bazarragchaa, Dement-Brown, Jessica, Li, Huifang, Tolnay, Mate

“…Abstract B cell response is modulated by an array of co-receptors which transduce activating and/or inhibitory signals. The balance of these stimuli will…”
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Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from that of Fc-receptors 1 by Franco, Andrea, Damdinsuren, Bazarragchaa, Ise, Tomoko, Dement-Brown, Jessica, Li, Huifang, Nagata, Satoshi, Tolnay, Mate

“…Fc receptor-like 5 (FCRL5) regulates BCR signaling and has been reported to bind aggregated IgG. Using surface plasmon resonance, we analyzed the interaction…”
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Considerations for the development of therapeutic monoclonal antibodies by Swann, Patrick G, Tolnay, Mate, Muthukkumar, Subramanian, Shapiro, Marjorie A, Rellahan, Barbara L, Clouse, Kathleen A

“…An increasing number of Investigational New Drug (IND) applications for therapeutic monoclonal antibodies (mAbs) have been submitted to US FDA over the past…”
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Human Fc receptor-like 5 promotes B cell proliferation and the development of cells displaying surface IgG and IgA (45.10) by Tolnay, Mate, Dement-Brown, Jessica, Newton, Christopher, Ise, Tomoko, Nagata, Satoshi

“…Abstract The functional roles of B cell membrane proteins belonging to the Fc receptor-like (FCRL) family are unclear. However, the demonstrated signaling…”
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Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1 by Mohan, Joanne, Dement-Brown, Jessica, Maier, Sabine, Ise, Tomoko, Kempkes, Bettina, Tolnay, Mate

“…Fc-receptor homolog 5 (FcRH5) is a recently identified B-cell membrane protein of unknown function. In Burkitt lymphoma cell lines with chromosome 1q21…”
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The Cyclic Adenosine 5'-Monophosphate Response Element Modulator Suppresses IL-2 Production in Stimulated T Cells by a Chromatin-Dependent Mechanism by Tenbrock, Klaus, Juang, Yuang-Taung, Tolnay, Mate, Tsokos, George C

“…The production of IL-2 is tightly controlled by several transcription factors that bind to the IL-2 promoter. The cAMP response element modulator (CREM) is…”
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