Search Results - "Tolmachev, Andrey A"

Ultra-large library docking for discovering new chemotypes by Lyu, Jiankun, Wang, Sheng, Balius, Trent E., Singh, Isha, Levit, Anat, Moroz, Yurii S., O’Meara, Matthew J., Che, Tao, Algaa, Enkhjargal, Tolmachova, Kateryna, Tolmachev, Andrey A., Shoichet, Brian K., Roth, Bryan L., Irwin, John J.

“…Despite intense interest in expanding chemical space, libraries containing hundreds-of-millions to billions of diverse molecules have remained inaccessible…”
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Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery by Bychek, Roman M., Levterov, Vadym V., Sadkova, Iryna V., Tolmachev, Andrey A., Mykhailiuk, Pavel K.

“…Difluorocyclopropane‐containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3/NaI. Novel fluorinated acids,…”
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[2+2]-Photocycloaddition of N‑Benzylmaleimide to Alkenes As an Approach to Functional 3‑Azabicyclo[3.2.0]heptanes by Skalenko, Yevhen A, Druzhenko, Tetiana V, Denisenko, Aleksandr V, Samoilenko, Maryna V, Dacenko, Oleksandr P, Trofymchuk, Serhii A, Grygorenko, Oleksandr O, Tolmachev, Andrey A, Mykhailiuk, Pavel K

“…A one-step synthesis of functionalized 3-azabicyclo[3.2.0]­heptanes by [2+2]-photochemical intermolecular cycloaddition of N-benzylmaleimide to alkenes was…”
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Twisting and Turning the Sulfonamide Bond: A Synthetic, Quantum Chemical, and Crystallographic Study by Blahun, Oleksandr P, Rozhenko, Alexander B, Rusanov, Eduard, Zhersh, Serhii, Tolmachev, Andrey A, Volochnyuk, Dmitriy M, Grygorenko, Oleksandr O

“…Structural restriction of the sulfonamide bond was used to design sultams with abnormal geometric parameters. Based on analysis of tertiary aliphatic…”
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Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery by Artamonov, Olexiy S., Slobodyanyuk, Evgeniy Y., Volochnyuk, Dmitriy M., Komarov, Igor V., Tolmachev, Andrey A., Mykhailiuk, Pavel K.

“…Five CF3‐substituted 3‐azabicyclo[n.1.0]alkanes were synthesized by CuCl‐mediated trifluoromethylcyclopropanation reaction of the corresponding cyclic enamides…”
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The homologous tert-amino effect: a route to fused 2-benzazepine derivatives by Gorulya, Alexander P., Tverdokhlebov, Anton V., Tolmachev, Andrey A., Shishkin, Oleg V., Shishkina, Svetlana V.

“…2-Cyano- and 2-carbethoxy-3-[2-(pyrrolidin-1-ylmethyl)phenyl]acrylonitriles were prepared through either amination of appropriate…”
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Synthesis of α‑C‑Stereochemically Pure Secondary Sulfonamides by Andriashvili, Vladyslav A, Zhersh, Serhii, Tolmachev, Andrey A, Grygorenko, Oleksandr O

“…A convenient “green” stereoretentive approach to sp 3 -enriched secondary sulfonamides bearing an asymmetric center at the α position to the sulfur atom is…”
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Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity by Levterov, Vadym V, Michurin, Oleg, Borysko, Petro O, Zozulya, Sergey, Sadkova, Iryna V, Tolmachev, Andrey A, Mykhailiuk, Pavel K

“…A practical synthesis of 2,4-methanopyrrolidines was elaborated. The key synthetic step was an intramolecular photochemical [2 + 2]-cycloaddition of an acrylic…”
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S N Ar or Sulfonylation? Chemoselective Amination of Halo(het)arene Sulfonyl Halides for Synthetic Applications and Ultralarge Compound Library Design by Naumchyk, Vasyl, Andriashvili, Vladyslav A, Radchenko, Dmytro S, Dudenko, Dmytro, Moroz, Yurii S, Tolmachev, Andrey A, Zhersh, Serhii, Grygorenko, Oleksandr O

“…The chemoselectivity of halo(het)arene sulfonyl halide aminations is studied thoroughly under parallel synthesis conditions, and the scope and limitations of…”
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SNAr or Sulfonylation? Chemoselective Amination of Halo(het)arene Sulfonyl Halides for Synthetic Applications and Ultralarge Compound Library Design by Naumchyk, Vasyl, Andriashvili, Vladyslav A., Radchenko, Dmytro S., Dudenko, Dmytro, Moroz, Yurii S., Tolmachev, Andrey A., Zhersh, Serhii, Grygorenko, Oleksandr O.

“…The chemoselectivity of halo­(het)­arene sulfonyl halide aminations is studied thoroughly under parallel synthesis conditions, and the scope and limitations of…”
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Sulfonimidamides and Imidosulfuric Diamides: Compounds from an Underexplored Part of Biologically Relevant Chemical Space by Zasukha, Sergiy V., Timoshenko, Vadim M., Tolmachev, Andrey A., Pivnytska, Valentyna O., Gavrylenko, Oleksii, Zhersh, Serhii, Shermolovich, Yuriy, Grygorenko, Oleksandr O.

“…Two novel solid reagents—1‐sulfonimidoyl‐ and 1‐sulfamimidoyl‐3‐methylimidazolium derivatives—for the synthesis of sulfonimidamides and imidosulfuric diamides,…”
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Challenges for chemistry in Ukraine after the war: Ukrainian science requires rebuilding and support by Kondratov, Ivan S, Moroz, Yurii S, Gorgulla, Christoph, Grygorenko, Oleksandr O, Komarov, Igor V, Wagner, Gerhard, Tolmachev, Andrey A

“…The unprovoked Russian invasion has created considerable challenges for Ukrainian science. In this article, we discuss actions needed to support and rebuild…”
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Heteroaliphatic Dimethylphosphine Oxide Building Blocks: Synthesis and Physico‐Chemical Properties by Fedyk, Andrii, Slobodyanyuk, Evgeniy Y., Stotska, Olha, Vashchenko, Bohdan V., Volochnyuk, Dmitriy M., Sibgatulin, Dmitriy A., Tolmachev, Andrey A., Grygorenko, Oleksandr O.

“…Scalable synthesis of saturated heterocyclic dimethyl phosphine oxides (derivatives of azetidine, pyrrolidine, piperidine, and morpholine) is disclosed. The…”
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[3+2] Cycloaddition of an Azomethyne Ylide and Vinyl Sulfonyl Fluorides ― an Approach to Pyrrolidine‐3‐sulfonyl Fluorides by Mykhalchuk, Volodymyr L., Yarmolchuk, Vladimir S., Doroschuk, Roman O., Tolmachev, Andrey A., Grygorenko, Oleksandr O.

“…[3+2] Cycloaddition reactions of vinyl sulfonyl fluorides with an in‐situ generated nonstabilized azomethine ylide is described for the first time. The…”
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Bicyclic Conformationally Restricted Diamines by Grygorenko, Oleksandr O, Radchenko, Dmytro S, Volochnyuk, Dmitriy M, Tolmachev, Andrey A, Komarov, Igor V

“…Grygorenko et al examine bicyclic conformationally restricted molecules diamines with regard to chemical synthesis…”
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Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting‐Group‐Free Synthesis of Sulfonamides by Zhersh, Sergey A., Blahun, Oleksandr P., Sadkova, Iryna V., Tolmachev, Andrey A., Moroz, Yurii S., Mykhailiuk, Pavel K.

“…Cyclic saturated aminosulfonyl fluorides were synthesized as their HCl salts. The compounds were found to be stable upon storage and could be used for the…”
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Hetaryl Bromides Bearing the SO2F Group – Versatile Substrates for Palladium‐Catalyzed C–C Coupling Reactions by Cherepakha, Artem Yu, Stepannikova, Kateryna O., Vashchenko, Bohdan V., Gorichko, Marian V., Tolmachev, Andrey A., Grygorenko, Oleksandr O.

“…Synthesis of novel five‐ and six‐membered heteroaromatic sulfonyl fluorides bearing bromine atom at various positions of the heterocyclic ring is described…”
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The Ukrainian Factor in Early-Stage Drug Discovery in the Context of Russian Invasion: The Case of Enamine Ltd by Kondratov, Ivan S., Moroz, Yurii S., Grygorenko, Oleksandr O., Tolmachev, Andrey A.

“…Ukrainian companies occupy an important niche in the global drug discovery process; however, before the Russian invasion, the role of Ukraine was not obvious…”
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Synthesis of Functionalized Bridged Bicyclic Sulfonamides with a Bridgehead Nitrogen Atom by Blahun, Oleksandr P., Melnychenko, Heorhii, Kuchkovska, Yuliya O., Zhersh, Serhii, Tolmachev, Andrey A., Grygorenko, Oleksandr O.

“…Two approaches to the synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead nitrogen atom were developed. The target compounds were…”
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Synthesis and chemical transformations of diazolyl α,α-difluoroacetates by Geraschenko, Oleksandr V., Solomin, Vitalii V., Vashchenko, Bohdan V., Khodakivskyi, Pavlo, Tolmachev, Andrey A., Grygorenko, Oleksandr O.

“…•An approach to a series of diazolyl α,α-difluoroacetates is developed.•The strategy is based on deoxofluorination of diazolyl glyoxylates with morph-DAST.•Two…”
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