Search Results - "Tolleson, William H"

The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p by Chen, Yinting, Zeng, Linjuan, Wang, Yong, Tolleson, William H., Knox, Bridgett, Chen, Si, Ren, Zhen, Guo, Lei, Mei, Nan, Qian, Feng, Huang, Kaihong, Liu, David, Tong, Weida, Yu, Dianke, Ning, Baitang

“…[Display omitted] Cytochrome P450 1A2 (CYP1A2) is one of the most abundant and important drug metabolizing enzymes in human liver. However, little is known…”
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A systematic evaluation of microRNAs in regulating human hepatic CYP2E1 by Wang, Yong, Yu, Dianke, Tolleson, William H., Yu, Li-Rong, Green, Bridgett, Zeng, Linjuan, Chen, Yinting, Chen, Si, Ren, Zhen, Guo, Lei, Tong, Weida, Guan, Huaijin, Ning, Baitang

“…[Display omitted] Cytochrome P450 2E1 (CYP2E1) is an important drug metabolizing enzyme for processing numerous xenobiotics in the liver, including…”
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Microcalorimetric Investigations of Reversible Staphylococcal Enterotoxin Unfolding by Berry, Susan C, Triplett, Odbert A, Yu, Li-Rong, Hart, Mark E, Jackson, Lauren S, Tolleson, William H

“…Staphylococcal food poisoning (SFP) is a common food-borne illness often associated with contamination during food handling. The genes for Staphylococcal…”
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A functional quantitative polymerase chain reaction assay for ricin, Shiga toxin, and related ribosome-inactivating proteins by Melchior, William B., Tolleson, William H.

“…The potent toxins ricin, abrin, and other ribosome-inactivating proteins deadenylate a specific base in 28S ribosomal RNA that destroys ribosomes and leads to…”
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Prolactin and Dehydroepiandrosterone Levels in Women with Systemic Lupus Erythematosus: The Role of the Extrapituitary Prolactin Promoter Polymorphism at −1149G/T by Lyn-Cook, Beverly, Gopee, Neera, Tolleson, William H., Melchior, William, Word, Beverly, Wiley, Kenneth, Treadwell, Edward L., Hammons, George

“…Systemic lupus erythematosus (SLE) has shown an association with high levels of prolactin, low levels of dehydroepiandrosterone (DHEA), and induction of…”
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Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro by Tolleson, William H, Doerge, Daniel R, Churchwell, Mona I, Marques, M. Matilde, Roberts, Dean W

“…Biochanin A and formononetin are abundant in legumes. These proestrogenic isoflavones can be converted by 4‘-O-demethylation to the more potent phytoestrogens…”
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Mitochondrial dysfunction induced by leflunomide and its active metabolite by Xuan, Jiekun, Ren, Zhen, Qing, Tao, Couch, Letha, Shi, Leming, Tolleson, William H., Guo, Lei

“…Leflunomide, an anti-inflammatory drug used for the treatment of rheumatoid arthritis, has been marked with a black box warning regarding an increased risk of…”
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Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis by Li, Dongying, Tolleson, William H., Yu, Dianke, Chen, Si, Guo, Lei, Xiao, Wenming, Tong, Weida, Ning, Baitang

“…Environmental exposures to hazardous chemicals are associated with a variety of human diseases and disorders, including cancers. Phase I metabolic activation…”
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Inhibition of Heme Peroxidases by Melamine by Vanachayangkul, Pattaraporn, Tolleson, William H.

“…In 2008 melamine-contaminated infant formula and dairy products in China led to over 50,000 hospitalizations of children due to renal injuries. In North…”
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Ricin detection: Tracking active toxin by Bozza, William P., Tolleson, William H., Rivera Rosado, Leslie A., Zhang, Baolin

“…Ricin is a plant toxin with high bioterrorism potential due to its natural abundance and potency in inducing cell death. Early detection of the active toxin is…”
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MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes by Jin, Yaqiong, Yu, Dianke, Tolleson, William H., Knox, Bridgett, Wang, Yong, Chen, Si, Ren, Zhen, Deng, Helen, Guo, Yongli, Ning, Baitang

“…[Display omitted] Cytochrome P450 2B6 (CYP2B6), mainly expressed in the liver and brain, is important for processing a number of widely used drugs. Variations…”
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Immunomagnetic Capture of Big Six Shiga Toxin-Producing Escherichia coli Strains in Apple Juice with Detection by Multiplex Real-Time PCR Eliminates Interference from the Food Matrix by Triplett, Odbert A, Xuan, Jiekun, Foley, Steven, Nayak, Rajesh, Tolleson, William H

“…Having reliable methods for detecting Shiga toxin-producing (STEC) in foods is an important food safety goal. The majority of STEC outbreaks have involved…”
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Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover) by Roberts, Dean W, Doerge, Daniel R, Churchwell, Mona I, Gamboa da Costa, Gonçalo, Marques, M. Matilde, Tolleson, William H

“…Biochanin A and formononetin are the predominant isoflavones in red clover. In a previous study (J. Agric. Food Chem. 2002, 50, 4783−4790), it was demonstrated…”
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MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation by Li, Dongying, Knox, Bridgett, Chen, Si, Wu, Leihong, Tolleson, William H., Liu, Zhichao, Yu, Dianke, Guo, Lei, Tong, Weida, Ning, Baitang

“…[Display omitted] Drug metabolizing enzymes mediate biotransformation of drugs and play an essential role in drug efficacy and toxicity. Human…”
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Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells by Chen, Si, Zhang, Zhuhong, Wu, Yuanfeng, Shi, Qiang, Yan, Hua, Mei, Nan, Tolleson, William H, Guo, Lei

“…The use of usnic acid as a weight loss agent is a safety concern due to reports of acute liver failure in humans. Previously we demonstrated that usnic acid…”
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Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells by Chen, Si, Zhang, Zhuhong, Qing, Tao, Ren, Zhen, Yu, Dianke, Couch, Letha, Ning, Baitang, Mei, Nan, Shi, Leming, Tolleson, William H., Guo, Lei

“…Many usnic acid-containing dietary supplements have been marketed as weight loss agents, although severe hepatotoxicity and acute liver failure have been…”
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Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells by He, Xiaobo, Xia, Qingsu, Wu, Qiangen, Tolleson, William H., Lin, Ge, Fu, Peter P.

“…Humans and animals can be exposed to carcinogenic pyrrolizidine alkaloids (PAs) through consumption of plants commonly found in many parts of the world…”
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Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells by Li, Dongying, Wu, Leihong, Knox, Bridgett, Chen, Si, Tolleson, William H., Liu, Fang, Yu, Dianke, Guo, Lei, Tong, Weida, Ning, Baitang

“…Noncoding RNAs, such as long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), regulate gene expression in many physiological and pathological processes,…”
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Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells by Yu, Dianke, Chen, Jing, Chen, Si, Xu, Lin, Wu, Leihong, Li, Dongying, Luo, Jiao, Jin, Yuan, Zhao, Yanjie, Knox, Bridgett, Tolleson, William H, Wang, Xubing, Guo, Lei, Tong, Weida, Ning, Baitang

“…Recent studies have shown that microRNAs and long noncoding RNAs (lncRNAs) regulate the expression of drug metabolizing enzymes (DMEs) in human hepatic cells…”
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Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans by Yu, Dianke, Wu, Leihong, Gill, Pritmohinder, Tolleson, William H., Chen, Si, Sun, Jinchun, Knox, Bridgett, Jin, Yaqiong, Xiao, Wenming, Hong, Huixiao, Wang, Yong, Ren, Zhen, Guo, Lei, Mei, Nan, Guo, Yongli, Yang, Xi, Shi, Leming, Chen, Yinting, Zeng, Linjuan, Dreval, Kostiantyn, Tryndyak, Volodymyr, Pogribny, Igor, Fang, Hong, Shi, Tieliu, McCullough, Sandra, Bhattacharyya, Sudeepa, Schnackenberg, Laura, Mattes, William, Beger, Richard D., James, Laura, Tong, Weida, Ning, Baitang

“…Acetaminophen (APAP) overdose is the leading cause of acute liver failure. Yet the mechanisms underlying adaptive tolerance toward APAP-induced liver injury…”
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