Search Results - "Tollenaere, Jan P"

Characterization of the interaction of 2-hydroxypropyl-beta-cyclodextrin with itraconazole at pH 2, 4, and 7 by Peeters, Jef, Neeskens, Peter, Tollenaere, Jan P, Van Remoortere, Pieter, Brewster, Marcus E

“…Phase-solubility techniques were used to assess the effect of pH on itraconazole complexation with 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD). In addition,…”
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Systematic Study of the Quality of Various Quantum Similarity Descriptors. Use of the Autocorrelation Function and Principal Component Analysis by Boon, Greet, Langenaeker, Wilfried, De Proft, Frank, De Winter, Hans, Tollenaere, Jan P, Geerlings, Paul

“…The quality of various quantum similarity descriptors is studied systematically for a series of peptide isosteres important in pharmacology. To cope with the…”
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Fast Calculation of Quantum Chemical Molecular Descriptors from the Electronegativity Equalization Method by Bultinck, Patrick, Langenaeker, Wilfried, Carbó-Dorca, Ramon, Tollenaere, Jan P

“…The use of the Electronegativity Equalization Method (EEM) is presented for high performance calculation of molecular electrostatic descriptors, giving quite…”
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Generate: A program for 3-D structure generation and conformational analysis of peptides and peptidomimetics by Bultinck, Patrick, Augustynen, Stijn, Hilbers, Hans W., Moret, Ed E., Tollenaere, Jan P.

“…The program Generate, aimed at generating 3‐D structures for peptides and peptidomimetics, is presented. The algorithm is based on a build‐up procedure, using…”
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CerBeruS:  A System Supporting the Sequential Screening Process by Engels, Michael F. M, Thielemans, Theo, Verbinnen, Danny, Tollenaere, Jan P, Verbeeck, Rudi

“…This paper describes the general design and application of CerBeruS, a computer-based system for supporting the process of sequential screening. CerBeruS…”
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Structure-activity relationships of astemizole derivatives for inhibition of store operated Ca2+ channels and exocytosis by FISCHER, M. J. E, PAULUSSEN, J. J. C, TOLLENAERE, J. P, DE MOL, N. J, JANSSEN, L. H. M

“…The effects of a series of analogues of the antiallergic drug astemizole on the exocytosis of the enzyme beta-hexosaminidase were studied in a mast cell model,…”
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Serotonergic component of neuroleptic receptors by LEYSEN, JOSÉE E, NIEMEGEERS, CARLOS J. E, TOLLENAERE, JAN P, LADURON, PIERRE M

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In Vivo Activity and Hydrophobicity of Cytostatic Aziridinyl Quinones by Moret, Ed E, de Boer, Mark, Hilbers, Hans W, Tollenaere, Jan P, Janssen, Lambert H. M, Holthuis, Joost J. M, Driebergen, Reinoud J, Verboom, Willem, Reinhoudt, David N

“…For a series of 3,6-disubstituted bisaziridinylbenzoquinones the in vivo and in vitro activities against murine tumors, as well as the in vivo toxicity, are…”
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Structure-activity relations of three groups of uncouplers of oxidative phosphorylation. Salicylanilides, 2-trifluoromethylbenzimidazoles, and phenols by Tollenaere, Jan P

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Possible ligand-receptor interactions for NK1 antagonists as observed in their crystal structures by Boks, G J, Tollenaere, J P, Kroon, J

“…Crystal structures of nine non-peptide tachykinin NK1 antagonists have been analysed for the intermolecular interactions of their pharmacophoric groups with…”
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Possible ligand-receptor interactions for NK 1 antagonists as observed in their crystal structures by Boks, Gertjan J., Tollenaere, Jan P., Kroon, Jan

“…Crystal structures of nine non-peptide tachykinin NK 1 antagonists have been analysed for the intermolecular interactions of their pharmacophoric groups with…”
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Structure–activity relationships of astemizole derivatives for inhibition of store operated Ca 2+ channels and exocytosis by Fischer, Marcel J.E., Paulussen, Jeannette J.C., Tollenaere, Jan P., De Mol, Nico J., Janssen, Lambert H.M.

“…The effects of a series of analogues of the antiallergic drug astemizole on the exocytosis of the enzyme β-hexosaminidase were studied in a mast cell model,…”
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CGEMA and VGAP: a Colour Graphics Editor for Multiple Alignment using a variable GAP penalty. Application to the muscarinic acetylcholine receptor by Moereels, H, De Bie, L, Tollenaere, J P

“…Today, more than 40 protein amino acid (AA) sequences of membrane receptors coupled to guanine nucleotide binding proteins (G-proteins) are available. For…”
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Structure-activity relationships of three groups of uncouplers of oxidative phosphorylation: salicylanilides, 2-trifluoromethylbenzimidazoles, and phenols by Tollenaere, J P

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Differentiation of opiate and neuroleptic receptor binding in rat brain by Leysen, J, Tollenaere, J P, Koch, M H, Laduron, P

“…For 6 large series of compounds derived from the piperidine moieties of spiperone, pimozide, haloperidol, pethidine, fentanyl and 4-methocarboxy-fentanyl, IC50…”
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Dependence of the antagonism at human platelet 5-HT2 receptors by ketanserin on the reaction pH by De Clerck, F, Xhonneux, B, Tollenaere, J P, Janssen, P A

“…The potency for the inhibition of 5-hydroxytryptamine (5-HT)-induced human platelet aggregation by ketanserin, pipamperone, spiperone, cyproheptadine and BW…”
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