Search Results - "Tolkovsky, A M"

Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function by Ciechomska, I A, Goemans, G C, Skepper, J N, Tolkovsky, A M

“…The binding of Bcl-2 to Beclin-1 reduces Beclin-1's capacity to induce autophagy. Here, we have tested whether the interaction is reciprocated by loss of…”
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Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis by Xue, L., Fletcher, G.C., Tolkovsky, A.M.

“…Pan caspase inhibitors are potentially powerful cell-protective agents that block apoptosis in response to a wide variety of insults that cause tissue…”
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puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila by Martín-Blanco, E, Gampel, A, Ring, J, Virdee, K, Kirov, N, Tolkovsky, A M, Martinez-Arias, A

“…The activation of MAPKs is controlled by the balance between MAPK kinase and MAPK phosphatase activities. The latter is mediated by a subset of phosphatases…”
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Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival by Virdee, K., Parone, P.A., Tolkovsky, A.M.

“…Phosphorylation of BAD, a pro-apoptotic member of the Bcl-2 protein family, on either Ser112 or Ser136 is thought to be necessary and sufficient for growth…”
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Characterization of Apoptosis in Cultured Rat Sympathetic Neurons after Nerve Growth Factor Withdrawal by Edwards, Susan N., Tolkovsky, Aviva M.

“…Sympathetic neurons depend on nerve growth factor (NGF) for their survival both in vivo and in vitro. In culture, the neurons die after NGF withdrawal by an…”
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CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults by MARONEY, A. C, FINN, J. P, BOZYCZKO-COYNE, D, O'KANE, T. M, NEFF, N. T, TOLKOVSKY, A. M, PARK, D. S, YAN, C. Y. I, TROY, C. M, GREENE, L. A

“…The c-Jun N-terminal kinase signaling cascade appears to play a role in some cases of cell death, including neuronal apoptosis. CEP-1347 (KT7515), an…”
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Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis by Al-Lamki, R S, Lu, W, Manalo, P, Wang, J, Warren, A Y, Tolkovsky, A M, Pober, J S, Bradley, J R

“…We previously reported that renal clear cell carcinoma cells (RCC) express both tumor necrosis factor receptor (TNFR)-1 and -2, but that, in organ culture, a…”
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The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration by Gumy, Laura F, Chew, Daniel J, Tortosa, Elena, Katrukha, Eugene A, Kapitein, Lukas C, Tolkovsky, Aviva M, Hoogenraad, Casper C, Fawcett, James W

“…Axon regeneration after injury requires the extensive reconstruction, reorganization, and stabilization of the microtubule cytoskeleton in the growth cones…”
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Phosphorylation of Puma modulates its apoptotic function by regulating protein stability by Fricker, M, O'Prey, J, Tolkovsky, A M, Ryan, K M

“…Puma is a potent BH3-only protein that antagonises anti-apoptotic Bcl-2 proteins, promotes Bax/Bak activation and has an essential role in multiple apoptotic…”
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Herpes Simplex Virus Type 1 Promoter Activity during Latency Establishment, Maintenance, and Reactivation in Primary Dorsal Root Neurons In Vitro by Arthur, J L, Scarpini, C G, Connor, V, Lachmann, R H, Tolkovsky, A M, Efstathiou, S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Comparison Between the Timing of JNK activation, c‐Jun Phosphorylation, and Onset of Death Commitment in Sympathetic Neurones by Virdee, Kanwar, Bannister, Andrew J., Hunt, Stephen P., Tolkovsky, Aviva M.

“…: We have investigated the relationship between c‐Jun N‐terminal kinase (JNK) activity, apoptosis, and the potential of survival factors to rescue primary rat…”
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Death Commitment Point Is Advanced by Axotomy in Sympathetic Neurons by Fletcher, Graham C., Xue, Luzheng, Passingham, Shareta K., Tolkovsky, Aviva M.

“…Axotomized neurons have several characteristics that are different from intact neurons. Here we show that, unlike established cultures, the axotomized…”
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Herbimycin A induces sympathetic neuron survival and protects against hypoxia by Cabral-da-Silva, M. C, Loureiro dos Santos, N. E, de Mello, F. G, Taylor, J. S. H, Tolkovsky, A. M, Linden, R, Reis, R. A. M

“…We have examined how herbimycin affects the survival and neuritogenesis of avian sympathetic neurons. Herbimycin promoted sympathetic neuron survival and…”
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Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons by Virdee, Kanwar, Xue, Luzheng, Hemmings, Brian A, Goemans, Christoph, Heumann, Rolf, Tolkovsky, Aviva M

“…Phosphoinositide 3-kinase and its downstream effector kinase PKB/Akt have been suggested to have crucial roles in suppressing apoptosis in several classes of…”
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Intra-mitochondrial degradation of Tim23 curtails the survival of cells rescued from apoptosis by caspase inhibitors by Goemans, C G, Boya, P, Skirrow, C J, Tolkovsky, A M

“…Caspase inhibition can extend the survival of cells undergoing apoptosis beyond the point of mitochondrial outer membrane permeabilisation (MOMP), but this…”
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Active p21Ras is sufficient for rescue of NGF-dependent rat sympathetic neurons by Nobes, C.D., Reppas, J.B., Markus, A., Tolkovsky, A.M.

“…We have examined whether p21Ras proteins can rescue nerve growth factor-deprived rat sympathetic neurons from death, to test further our hypothesis that p21Ras…”
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Autophagy Is Activated by Apoptotic Signalling in Sympathetic Neurons: An Alternative Mechanism of Death Execution by Xue, Luzheng, Fletcher, Graham C., Tolkovsky, Aviva M.

“…Autophagy is a mechanism whereby cells digest themselves from within and so may be used in lieu of apoptosis to execute cell death. Little is known about its…”
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Elan vital, élan létal: one life but multiple deaths by Kroemer, G, Tolkovsky, A M, Zakeri, Z

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Apoptosis is induced in post-mitotic rat sympathetic neurons by arabinosides and topoisomerase II inhibitors in the presence of NGF by TOMKINS, C. E, EDWARDS, S. N, TOLKOVSKY, A. M

“…Sympathetic neurons depend on nerve growth factor (NGF) for their survival and die by apoptosis when NGF is withdrawn, despite their post-mitotic state. Martin…”
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A Role for MAPK/ERK in Sympathetic Neuron Survival: Protection against a p53-Dependent, JNK-Independent Induction of Apoptosis by Cytosine Arabinoside by Anderson, Christopher N. G, Tolkovsky, Aviva M

“…The antimitotic nucleoside cytosine arabinoside (araC) causes apoptosis in postmitotic neurons for which two mechanisms have been suggested: (1) araC directly…”
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