Search Results - "Toldi, Jozsef"

Migraine, Neurogenic Inflammation, Drug Development - Pharmacochemical Aspects by Lukacs, Melinda, Tajti, Janos, Fulop, Ferenc, Toldi, Jozsef, Edvinsson, Lars, Vecsei, Laszlo

“…Migraine is a primary headache disorder. Despite numerous studies conducted with the aim to understand the pathophysiology of migraine, several aspects are…”
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The Therapeutic Impact of New Migraine Discoveries by Vécsei, László, Lukács, Melinda, Tajti, János, Fülöp, Ferenc, Toldi, József, Edvinsson, Lars

“…Migraine is one of the most disabling neurological conditions and associated with high socio-economic costs. Though certain aspects of the pathomechanism of…”
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The role of kynurenines in disorders of the central nervous system: Possibilities for neuroprotection by Vamos, Eniko, Pardutz, Arpad, Klivenyi, Peter, Toldi, Jozsef, Vecsei, Laszlo

“…Abstract The metabolism of tryptophan mostly proceeds through the kynurenine pathway. The biochemical reaction includes both an agonist (quinolinic acid) at…”
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Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines by Tanaka, Masaru, Toldi, József, Vécsei, László

“…Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor…”
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Manipulating kynurenic acid levels in the brain - on the edge between neuroprotection and cognitive dysfunction by Szalardy, Levente, Zadori, Denes, Toldi, Jozsef, Fulop, Ferenc, Klivenyi, Peter, Vecsei, Laszlo

“…A number of neurodegenerative diseases have been associated with potentially neurotoxic alterations in the kynurenine pathway. Due to the potent inhibitory…”
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Excitotoxic Mechanisms in Non-Motor Dysfunctions and Levodopa- Induced Dyskinesia in Parkinson's Disease: The Role of the Interaction Between the Dopaminergic and the Kynurenine System by Majláth, Zsófia, Toldi, József, Fülöp, Ferenc, Vécsei, László

“…Parkinson's disease is a common progressive neurodegenerative disorder presenting with characteristic motor symptoms. Non-motor dysfunctions and therapyrelated…”
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Novel kynurenic acid analogues in the treatment of migraine and neurodegenerative disorders: preclinical studies and pharmaceutical design by Tajti, Janos, Majlath, Zsofia, Szok, Delia, Csati, Anett, Toldi, Jozsef, Fulop, Ferenc, Vecsei, Laszlo

“…Though migraine and neurodegenerative disorders have a high socioeconomic impact, their therapeutic management has not been fully addressed. Their…”
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Kynurenines and drug research by Tóth, Fanni, Fülöp, Ferenc, Szatmári, István, Toldi, József, Dékány, Imre, Vécsei, László

“…Currently kynurenines are considered a hot topic, because of their involvement in numerous physiological and pathological processes. The essential amino acid,…”
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Effect of probenecid on the pain-related behaviour and morphological markers in orofacial formalin test of the rat by Fejes-Szabó, Annamária, Bohár, Zsuzsanna, Nagy-Grócz, Gábor, Vámos, Enikő, Tar, Lilla, Pődör, Borbála, Tajti, János, Toldi, József, Vécsei, László, Párdutz, Árpád

“…Probenecid has been widely used in the treatment of gout, but evidence suggests that it may also have antinociceptive effects in different inflammatory and…”
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Oxaloacetate restores the long-term potentiation impaired in rat hippocampus CA1 region by 2-vessel occlusion by Marosi, Máté, Fuzik, János, Nagy, Dávid, Rákos, Gabriella, Kis, Zsolt, Vécsei, László, Toldi, József, Ruban-Matuzani, Angela, Teichberg, Vivian I., Farkas, Tamás

“…Various acute brain pathological conditions are characterized by the presence of elevated glutamate concentrations in the brain interstitial fluids. It has…”
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Kynurenines in the CNS: recent advances and new questions by Vécsei, László, Szalárdy, Levente, Fülöp, Ferenc, Toldi, József

“…Key Points Kynurenic acid has potentially neuroprotective actions, such as antagonism at NMDA ( N -methyl- D -aspartate) receptors, inhibition of glutamate…”
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Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood-brain barrier permeability by Oláh, Gáspár, Herédi, Judit, Menyhárt, Akos, Czinege, Zsolt, Nagy, Dávid, Fuzik, János, Kocsis, Kitti, Knapp, Levente, Krucsó, Erika, Gellért, Levente, Kis, Zsolt, Farkas, Tamás, Fülöp, Ferenc, Párdutz, Arpád, Tajti, János, Vécsei, László, Toldi, József

“…Cortical spreading depression (CSD) involves a slowly-propagating depolarization wave in the cortex, which can appear in numerous pathophysiological…”
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Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders by Sas, Katalin, Robotka, Hermina, Toldi, József, Vécsei, László

“…Abstract The mitochondria have several important functions in the cell. A mitochondrial dysfunction causes an abatement in ATP production, oxidative damage and…”
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Changing the face of kynurenines and neurotoxicity: therapeutic considerations by Bohár, Zsuzsanna, Toldi, József, Fülöp, Ferenc, Vécsei, László

“…Kynurenines are the products of tryptophan metabolism. Among them, kynurenine and kynurenic acid are generally thought to have neuroprotective properties,…”
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Protective effects of glucosamine-kynurenic acid after compression-induced spinal cord injury in the rat by Korimová Andrea, Cížková Dáša, Toldi Jozsef, Vécsei László, Vanický Ivo

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Species-specific neuronal localization of kynurenine aminotransferase-2 in the mouse cerebellum by Balog, Emma, Jenei, Gyula, Gellért, Levente, Ono, Etsuro, Vécsei, László, Toldi, József, Kis, Zsolt

“…The immunohistochemical pattern of kynurenine aminotransferase-2 (KAT-2) - the key role enzyme in the production of neuroactive and neuroprotective kynurenic…”
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Altered tryptophan metabolism in Parkinson's disease: A possible novel therapeutic approach by Szabó, Nikoletta, Kincses, Zsigmond Tamás, Toldi, József, Vécsei, Laszló

“…Abstract Parkinson's disease (PD) is one of the most common disabling neurodegenerative diseases. Although several therapeutic approaches are available, there…”
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Structural Evaluation and Electrophysiological Effects of Some Kynurenic Acid Analogs by Fehér, Evelin, Szatmári, István, Dudás, Tamás, Zalatnai, Anna, Farkas, Tamás, Lőrinczi, Bálint, Fülöp, Ferenc, Vécsei, László, Toldi, József

“…Kynurenic acid (KYNA), a metabolite of tryptophan, as an excitatory amino acid receptor antagonist is an effective neuroprotective agent in case of…”
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Glutamatergic dysfunctioning in Alzheimer's disease and related therapeutic targets by Zádori, Dénes, Veres, Gábor, Szalárdy, Levente, Klivényi, Péter, Toldi, József, Vécsei, László

“…The impairment of glutamatergic neurotransmission plays an important role in the development of Alzheimer's disease (AD). The pathological process, which…”
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Memantine and Kynurenic Acid: Current Neuropharmacological Aspects by Majlath, Zsofia, Torok, Nora, Toldi, Jozsef, Vecsei, Laszlo

“…Glutamatergic neurotransmission, of special importance in the human brain, is implicated in key brain functions such as synaptic plasticity and memory. The…”
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