Search Results - "Tolbert, Audrey E."

Making or Breaking Metal‐Dependent Catalytic Activity: The Role of Stammers in Designed Three‐Stranded Coiled Coils by Pinter, Tyler B. J., Manickas, Elizabeth C., Tolbert, Audrey E., Koebke, Karl J., Deb, Aniruddha, Penner‐Hahn, James E., Pecoraro, Vincent L.

“…While many life‐critical reactions would be infeasibly slow without metal cofactors, a detailed understanding of how protein structure can influence catalytic…”
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Co(II) Substitution Enhances the Esterase Activity of a de Novo Designed Zn(II) Carbonic Anhydrase by Borghesani, Valentina, Zastrow, Melissa L., Tolbert, Audrey E., Deb, Aniruddha, Penner‐Hahn, James E., Pecoraro, Vincent L.

“…Carbonic Anhydrases (CAs) have been a target for de novo protein designers due to the simplicity of the active site and rapid rate of the reaction. The first…”
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Heteromeric three-stranded coiled coils designed using a Pb(ii)(Cys)3 template mediated strategy by Tolbert, Audrey E., Ervin, Catherine S., Ruckthong, Leela, Paul, Thomas J., Jayasinghe-Arachchige, Vindi M., Neupane, Kosh P., Stuckey, Jeanne A., Prabhakar, Rajeev, Pecoraro, Vincent L.

“…Three-stranded coiled coils are peptide structures constructed from amphipathic heptad repeats. Here we show that it is possible to form pure heterotrimeric…”
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Rational De Novo Design of a Cu Metalloenzyme for Superoxide Dismutation by Mathieu, Emilie, Tolbert, Audrey E., Koebke, Karl J., Tard, Cédric, Iranzo, Olga, Penner‐Hahn, James E., Policar, Clotilde, Pecoraro, Vincent

“…Superoxide dismutases (SODs) are highly efficient enzymes for superoxide dismutation and the first line of defense against oxidative stress. These…”
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Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension by Zhang, Shan-Shan, Larrabee, Lance, Chang, Andrew H., Desai, Sapna, Sloan, Lisa, Wang, Xin, Wu, Yixuan, Parvez, Nazia, Amaratunga, Karen, Hartman, Allison C., Whitnall, Abby, Mason, Joseph, Barton, Nicholas P., Chu, Audrey Y., Davitte, Jonathan M., Csakai, Adam J., Tibbetts, Caitlin Vestal, Tolbert, Audrey E., O’Keefe, Heather, Polanco, Jessie, Foley, Joseph, Kmett, Casey, Kehler, Jonathan, Kozejova, Gabriela, Wang, Feng, Mayer, Andrew P., Koenig, Patrick, Foletti, Davide, Pitts, Steven J., Schnackenberg, Christine G.

“…Hypertension remains a leading cause of cardiovascular and kidney diseases. Failure to control blood pressure with ≥ 3 medications or control requiring ≥ 4…”
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The Use of Antioxidants to Improve Vapor Pressure Measurements on Compounds with Oxidative Instability: Methyl Oleate with tert-Butylhydroquinone by Widegren, Jason A, Beall, Casey E, Tolbert, Audrey E, Lovestead, Tara M, Bruno, Thomas J

“…The vapor pressure (p sat) of methyl oleate was measured with and without the addition of 0.2 mass % of the antioxidant stabilizer tert-butylhydroquinone…”
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Making or Breaking Metal‐Dependent Catalytic Activity: The Role of Stammers in Designed Three‐Stranded Coiled Coils by Pinter, Tyler B. J., Manickas, Elizabeth C., Tolbert, Audrey E., Koebke, Karl J., Deb, Aniruddha, Penner‐Hahn, James E., Pecoraro, Vincent L.

“…While many life‐critical reactions would be infeasibly slow without metal cofactors, a detailed understanding of how protein structure can influence catalytic…”
Get full text