Search Results - "Tolan, R."

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease by Jensen, Thomas, Abdelmalek, Manal F., Sullivan, Shelby, Nadeau, Kristen J., Green, Melanie, Roncal, Carlos, Nakagawa, Takahiko, Kuwabara, Masanari, Sato, Yuka, Kang, Duk-Hee, Tolan, Dean R., Sanchez-Lozada, Laura G., Rosen, Hugo R., Lanaspa, Miguel A., Diehl, Anna Mae, Johnson, Richard J.

“…Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome; its rising prevalence parallels the rise in obesity and diabetes…”
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Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton by Hu, Hai, Juvekar, Ashish, Lyssiotis, Costas A., Lien, Evan C., Albeck, John G., Oh, Doogie, Varma, Gopal, Hung, Yin Pun, Ullas, Soumya, Lauring, Josh, Seth, Pankaj, Lundquist, Mark R., Tolan, Dean R., Grant, Aaron K., Needleman, Daniel J., Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.

“…The phosphoinositide 3-kinase (PI3K) pathway regulates multiple steps in glucose metabolism and also cytoskeletal functions, such as cell movement and…”
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Fructose Production and Metabolism in the Kidney by Nakagawa, Takahiko, Johnson, Richard J, Andres-Hernando, Ana, Roncal-Jimenez, Carlos, Sanchez-Lozada, Laura G, Tolan, Dean R, Lanaspa, Miguel A

“…Understanding fructose metabolism might provide insights to renal pathophysiology. To support systemic glucose concentration, the proximal tubular cells…”
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Specific regions of the brain are capable of fructose metabolism by Oppelt, Sarah A, Zhang, Wanming, Tolan, Dean R

“…Highlights • Bioinformatics predicts that brain expresses genes specific for fructose metabolism. • ISH confirms bioinformatic predictions and visualizes gene…”
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Targeting of Several Glycolytic Enzymes Using RNA Interference Reveals Aldolase Affects Cancer Cell Proliferation through a Non-glycolytic Mechanism by Lew, Carolyn Ritterson, Tolan, Dean R.

“…In cancer, glucose uptake and glycolysis are increased regardless of the oxygen concentration in the cell, a phenomenon known as the Warburg effect. Several…”
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Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure by Sato, Yuka, Roncal-Jimenez, Carlos A, Andres-Hernando, Ana, Jensen, Thomas, Tolan, Dean R, Sanchez-Lozada, Laura G, Newman, Lee S, Butler-Dawson, Jaime, Sorensen, Cecilia, Glaser, Jason, Miyazaki, Makoto, Diaz, Henry F, Ishimoto, Takuji, Kosugi, Tomoki, Maruyama, Shoichi, Garcia, Gabriela E, Lanaspa, Miguel A, Johnson, Richard J

“…An epidemic of chronic kidney disease of unknown etiology (Mesoamerican nephropathy) has emerged in hot regions of Central America. We have demonstrated that…”
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Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer’s Disease by Johnson, Richard J., Gomez-Pinilla, Fernando, Nagel, Maria, Nakagawa, Takahiko, Rodriguez-Iturbe, Bernardo, Sanchez-Lozada, Laura G., Tolan, Dean R., Lanaspa, Miguel A.

“…The loss of cognitive function in Alzheimer’s disease is pathologically linked with neurofibrillary tangles, amyloid deposition, and loss of neuronal…”
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Fructose contributes to the Warburg effect for cancer growth by Nakagawa, Takahiko, Lanaspa, Miguel A, Millan, Inigo San, Fini, Mehdi, Rivard, Christopher J, Sanchez-Lozada, Laura G, Andres-Hernando, Ana, Tolan, Dean R, Johnson, Richard J

“…Obesity and metabolic syndrome are strongly associated with cancer, and these disorders may share a common mechanism. Recently, fructose has emerged as a…”
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Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans by Oppelt, Sarah A., Sennott, Erin M., Tolan, Dean R.

“…The rise in fructose consumption, and its correlation with symptoms of metabolic syndrome (MBS), has highlighted the need for a better understanding of…”
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Endogenous Fructose Production and Metabolism Drive Metabolic Dysregulation and Liver Disease in Mice with Hereditary Fructose Intolerance by Andres-Hernando, Ana, Orlicky, David J, Kuwabara, Masanari, Cicerchi, Christina, Pedler, Michelle, Petrash, Mark J, Johnson, Richard J, Tolan, Dean R, Lanaspa, Miguel A

“…Excessive intake of sugar, and particularly fructose, is closely associated with the development and progression of metabolic syndrome in humans and animal…”
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Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin dynamics by Lew, Carolyn Ritterson, Tolan, Dean R.

“…In addition to its roles in sugar metabolism, fructose‐1,6‐bisphosphate aldolase (aldolase) has been implicated in cellular functions independent from these…”
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Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice by Song 宋志林, Zhilin, Roncal-Jimenez, Carlos A, Lanaspa-Garcia, Miguel A, Oppelt, Sarah A, Kuwabara, Masanari, Jensen, Thomas, Milagres, Tamara, Andres-Hernando, Ana, Ishimoto, Takuji, Garcia, Gabriela E, Johnson, Ginger, MacLean, Paul S, Sanchez-Lozada, Laura-Gabriela, Tolan, Dean R, Johnson, Richard J

“…Fructose stimulates vasopressin in humans and can be generated endogenously by activation of the polyol pathway with hyperosmolarity. We hypothesized that…”
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Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts by Johnson, R. J., Stenvinkel, P., Andrews, P., Sánchez‐Lozada, L. G., Nakagawa, T., Gaucher, E., Andres‐Hernando, A., Rodriguez‐Iturbe, B., Jimenez, C. R., Garcia, G., Kang, D.‐H., Tolan, D. R., Lanaspa, M. A.

“…Mass extinctions occur frequently in natural history. While studies of animals that became extinct can be informative, it is the survivors that provide clues…”
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Fructose might be a clue to the origin of preeclampsia insights from nature and evolution by Nakagawa, Takahiko, Ana Andres-Hernando, Kosugi, Tomoki, Sanchez-Lozada, Laura G, Stenvinkel, Peter, Kublickiene, Karolina, Ananth Karumanchi, S, Kang, Duk-Hee, Kojima, Hideto, Rodriguez-Iturbe, Bernardo, Tolan, Dean R, Lanaspa, Miguel A, Johnson, Richard J

“…Preeclampsia is a hypertensive disorder of pregnancy and is due to abnormal placentation. The pathogenesis remains unclear. Fructose is biologically distinct…”
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Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency by Buziau, Amée M., Oosterveer, Maaike H., Wouters, Kristiaan, Bos, Trijnie, Tolan, Dean R., Agius, Loranne, Ford, Brian E., Cassiman, David, Stehouwer, Coen D.A., Schalkwijk, Casper G., Brouwers, Martijn C.G.J.

“…Stable isotope studies have shown that hepatic de novo lipogenesis (DNL) plays an important role in the pathogenesis of intrahepatic lipid (IHL) deposition…”
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Activation of AMPD2 drives metabolic dysregulation and liver disease in mice with hereditary fructose intolerance by Andres-Hernando, Ana, Orlicky, David J., Kuwabara, Masanari, Fini, Mehdi A., Tolan, Dean R., Johnson, Richard J., Lanaspa, Miguel A.

“…Hereditary fructose intolerance (HFI) is a painful and potentially lethal genetic disease caused by a mutation in aldolase B resulting in accumulation of…”
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Infertility, in vitro fertilization and congenital tuberculosis by Flibotte, J J, Lee, G E, Buser, G L, Feja, K N, Kreiswirth, B N, McSherry, G D, Nolan, S M, Tolan, R W, Zhang, H

“…Congenital tuberculosis (CTB) due to maternal genitourinary (GU) TB infection is a rare occurrence, as infection of the genital tract in women generally leads…”
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Detection of Congenital Cytomegalovirus Infection by Real-Time Polymerase Chain Reaction Analysis of Saliva or Urine Specimens by Ross, Shannon A., Ahmed, Amina, Palmer, April L., Michaels, Marian G., Sánchez, Pablo J., Bernstein, David I., Tolan, Robert W., Novak, Zdenek, Chowdhury, Nazma, Fowler, Karen B., Boppana, Suresh B.

“…Viral culture of urine or saliva has been the gold standard technique for the diagnosis of congenital cytomegalovirus (CMV) infection. Results of rapid culture…”
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Snapshots of Catalysis:  the Structure of Fructose-1,6-(bis)phosphate Aldolase Covalently Bound to the Substrate Dihydroxyacetone Phosphate by Choi, Kyung H, Shi, Jun, Hopkins, Christopher E, Tolan, Dean R, Allen, Karen N

“…Fructose-1,6-bis(phosphate) aldolase is an essential glycolytic enzyme found in all vertebrates and higher plants that catalyzes the cleavage of fructose…”
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Michaelis‐like complex of mouse ketohexokinase isoform C by Gasper, William C., Gardner, Sarah, Ross, Adam, Oppelt, Sarah A., Allen, Karen N., Tolan, Dean R.

“…Over the past forty years there has been a drastic increase in fructose‐related diseases, including obesity, heart disease and diabetes. Ketohexokinase (KHK),…”
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